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公开(公告)号：US20190290647A1
公开(公告)日：2019-09-26
申请号：US16347924
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Yinhong CHEN , Mikkel V. DEBENEDETTO , Paul John DRANSFIELD , James S. HARVEY , Jonathan HOUZE , Aarif Yusuf KHAKOO , Su-Jen LAI , Zhihua MA , Nobuko NISHIMURA , Vatee PATTAROPONG , Gayathri SWAMINATH , Wen-Chen YEH , Philip Dean RAMSDEN , Ankit SHARMA
IPC: A61K31/506 , A61P9/04 , C07D403/12 , C07D403/14 , C07D401/12 , C07D401/14 , A61K31/4439 , C07D405/14
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.
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公开(公告)号：US20190284173A1
公开(公告)日：2019-09-19
申请号：US16347955
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Ning CHEN , Yinhong CHEN , Mikkel V. DEBENEDETTO , Paul John DRANSFIELD , James S. HARVEY , Julie Anne HEATH , Jonathan HOUZE , Aarif Yusuf KHAKOO , Su-Jen LAI , Zhihua MA , Nobuko NISHIMURA , Vatee PATTAROPONG , Gayathri SWAMINATH , Wen-Chen YEH , Charles KREIMAN
IPC: C07D403/14 , C07D403/04 , C07D249/14 , C07D403/12 , C07D401/04 , C07D401/14 , C07D405/14 , C07D239/24 , C07D417/12 , C07D241/12 , A61P9/04
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.
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公开(公告)号：US20180319773A1
公开(公告)日：2018-11-08
申请号：US16033632
申请日：2018-07-12
Applicant: AMGEN INC.
Inventor： Ning CHEN , Xiaoqi CHEN , Yinhong CHEN , Alan C. CHENG , Richard V. CONNORS , Jeffrey DEIGNAN , Paul John DRANSFIELD , Xiaohui DU , Zice FU , Julie Anne HEATH , Daniel B. HORNE , Jonathan HOUZE , Matthew R. KALLER , Aarif Yusuf KHAKOO , David John KOPECKY , Su-Jen LAI , Zhihua MA , Lawrence R. MCGEE , Julio C. MEDINA , Jeffrey T. MIHALIC , Nobuko NISHIMURA , Steven H. OLSON , Vatee PATTAROPONG , Gayathri SWAMINATH , Xiaodong WANG , Kevin YANG , Wen-Chen YEH , Mikkel V. DEBENEDETTO , Robert P. FARRELL , Simon J. HEDLEY , Ted C. JUDD , Frank KAYSER
IPC: C07D401/14 , C07D401/12 , A61K31/437 , C07D417/14 , A61K45/06 , C07B57/00 , C07B59/00 , C07D211/54 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D241/12 , C07D241/24 , C07D249/08 , C07D471/04 , C07D413/14 , C07D413/04 , C07D401/04 , C07D213/61 , C07D239/34 , C07D241/18 , C07F7/08 , C07D295/16 , C07C311/13 , A61K31/695 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , C07D405/14
CPC classification number: C07D401/14 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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公开(公告)号：US20170281625A1
公开(公告)日：2017-10-05
申请号：US15629567
申请日：2017-06-21
Applicant: AMGEN INC.
Inventor： Ning Chen , Xiaoqi CHEN , Yinhong CHEN , Zice FU , Julie Anne HEATH , Daniel B. HORNE , Matthew R. KALLER , Aarif Yusuf KHAKOO , David John KOPECKY , Zhihua MA , Jeffrey T. MIHALIC , Gayathri SWAMINATH , Xiaodong WANG , Wen-Chen YEH
IPC: A61K31/506 , A61K45/06 , A61K31/497
CPC classification number: A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
Abstract: Methods of treating heart failure include administering to a subject having heart failure an effective amount of a triazole compound that is an agonist of the APJ receptor, a pharmaceutically acceptable salt of the compound, or a mixture thereof. Compounds particularly useful in such methods are provided herein.
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公开(公告)号：US20170044131A1
公开(公告)日：2017-02-16
申请号：US15298434
申请日：2016-10-20
Applicant: AMGEN INC.
Inventor： Ning CHEN , Xiaoqi CHEN , Yinhong CHEN , Alan C. CHENG , Richard V. CONNORS , Jeffrey DEIGNAN , Paul John DRANSFIELD , Xiaohui DU , Zice FU , Julie Anne HEATH , Daniel B. HORNE , Jonathan HOUZE , Matthew R. KALLER , Aarif Yusuf KHAKOO , David John KOPECKY , Su-Jen LAI , Zhihua MA , Lawrence R. MCGEE , Julio C. MEDINA , Jeffrey T. MIHALIC , Nobuko NISHIMURA , Steven H. OLSON , Vatee PATTAROPONG , Gayathri SWAMINATH , Xiaodong WANG , Kevin YANG , Wen-Chen YEH , Mikkel V. DEBENEDETTO , Robert P. FARRELL , Simon J. HEDLEY , Ted C. JUDD , Frank KAYSER
IPC: C07D401/04 , A61K45/06 , C07D401/14 , A61K31/506 , C07D417/14 , A61K31/444 , A61K31/497 , A61K31/513 , C07D471/04 , A61K31/4439 , C07D413/14
CPC classification number: A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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Patent Agency Ranking
公开(公告)号：US20160067347A1
公开(公告)日：2016-03-10
申请号：US14654501
申请日：2013-12-17
Applicant: AMGEN INC.
Inventor： Jerry Ryan HOLDER , Gayathri SWAMINATH , Leslie P. MIRANDA , Jennifer ARAL , Elizabeth M. DOHERTY , Thomas NIXEY
CPC classification number: A61K47/48215 , A61K38/08 , A61K38/10 , A61K47/60 , A61K47/6811 , C07K7/08 , C07K14/47 , C07K14/503
Abstract: The application is directed to APJ receptor agonist analogs having increased stability relative to the wild type apelin-13 and methods of using the agonist analogs. The analogs can be used, inter alia, in cardiac disorders such as heart failure.
Abstract translation: 该应用涉及相对于野生型apelin-13具有增加的稳定性的APJ受体激动剂类似物和使用激动剂类似物的方法。 类似物尤其可用于心脏病，例如心力衰竭。
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公开(公告)号：US20240327461A1
公开(公告)日：2024-10-03
申请号：US18497081
申请日：2024-06-11
Applicant: AMGEN INC.
Inventor： Jerry Ryan HOLDER , Gayathri SWAMINATH , Michael J. FROHN , Brian Alan LANMAN , Anthony B. REED , Leslie P. MIRANDA , John Gordon ALLEN , Alexander J. PICKRELL , Aaron C. SIEGMUND , Lewis D. PENNINGTON , Bryant YANG
CPC classification number: C07K7/08 , A61K38/10 , A61K47/542 , A61K47/60 , C07K14/47 , A61K38/00 , C07K2319/30
Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
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公开(公告)号：US20210261619A1
公开(公告)日：2021-08-26
申请号：US17160819
申请日：2021-01-28
Applicant: AMGEN INC.
Inventor： Jerry Ryan HOLDER , Gayathri SWAMINATH , Michael J. FROHN , Brian Alan LANMAN , Anthony B. REED , Leslie P. MIRANDA , John Gordon ALLEN , Alexander J. PICKRELL , Aaron C. SIEGMUND , Lewis D. PENNINGTON , Bryant YANG
Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
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公开(公告)号：US20190300507A1
公开(公告)日：2019-10-03
申请号：US16347970
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Yinhong CHEN , Alan C. CHENG , Mikkel V. DEBENEDETTO , Paul John DRANSFIELD , James S. HARVEY , Jonathan HOUZE , Aarif Yusuf KHAKOO , Su-Jen LAI , Zhihua MA , Vatee PATTAROPONG , Gayathri SWAMINATH , Charles KREIMAN , David C. MOEBIUS , Ankit SHARMA
IPC: C07D401/14 , C07D405/14 , C07D417/14 , C07D413/14 , A61P9/04
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, I or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.
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公开(公告)号：US20190290648A1
公开(公告)日：2019-09-26
申请号：US16347942
申请日：2017-11-03
Applicant: AMGEN INC.
Inventor： Yinhong CHEN , Paul John DRANSFIELD , James S. HARVEY , Julie Anne HEATH , Jonathan HOUZE , Aarif Yusuf KHAKOO , David J. KOPECKY , Su-Jen LAI , Zhihua MA , Nobuko NISHIMURA , Vatee PATTAROPONG , Gayathri SWAMINATH , Wen-Chen YEH , Philip Dean RAMSDEN
IPC: A61K31/506 , A61P9/04 , C07D403/12 , C07D405/14 , C07D401/14
Abstract: Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I) (II) where the definitions of the variables are provided herein.
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