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公开(公告)号:US11266777B2
公开(公告)日:2022-03-08
申请号:US16071873
申请日:2017-02-13
Applicant: AMGEN INC.
Inventor: Scott R. Gibson , Sheldon B. Moberg , Basel Hasan Taha , Margaux Frances Boyaval , Mark A. Destefano , John C. Love , Ian B. Hanson , Paul F. Bente, IV , Matthew J. Clemente , Rajan Ramaswamy , Daniel S. Codd , Scott Beaver , Kevin L. Bokelman , Sean M. O'connor , Robert Decker , Gautam N. Shetty , Ryan M. Agard , Nicholas J. Ciccarelli , Daniel Davenport
Abstract: Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.
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公开(公告)号:US12201809B2
公开(公告)日:2025-01-21
申请号:US17386659
申请日:2021-07-28
Applicant: AMGEN INC.
Inventor: Scott R. Gibson , Sheldon B. Moberg , Basel Hasan Taha , Margaux Frances Boyaval , Mark A. Destefano , Lawton Laurence , John C. Love , Ian B. Hanson , Paul F. Bente, IV , Matthew J. Clemente , Antonio Ubach , Rajan Ramaswamy , Daniel S. Codd , Scott Beaver , Kevin L. Bokelman , Ian P. Dardani , Sean M. O'connor , Danielle Feldman
Abstract: Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.
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公开(公告)号:US20240066206A1
公开(公告)日:2024-02-29
申请号:US17767475
申请日:2020-09-29
Applicant: AMGEN INC.
Inventor: Heejin Lee , Daniel Eduardo Groszmann , Sheldon B. Moberg , Mohammad Bonakdar , Rasmus Ohlenschlaeger
IPC: A61M5/142
CPC classification number: A61M5/142 , A61M2205/123 , A61M2205/3368 , A61M2205/3633 , A61M2205/584 , A61M2205/585 , A61M2207/00
Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle assembly, and a temperature indicator. The housing defines an inner volume and includes at least one opening. The container contains a medicament which is urged out of the container by the activation mechanism. The needle assembly has a needle and/or a cannula to deliver the medicament from the container. The temperature indicator is operably coupled with the outer surface of the container and is responsive to a change in temperature of the container.
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公开(公告)号:US20230347075A1
公开(公告)日:2023-11-02
申请号:US17780596
申请日:2020-11-17
Applicant: AMGEN INC.
Inventor: Ali Nekouzadeh , Mehran Mojarrad , Joshua Tamsky , Paul Daniel Faucher , Scott R. Gibson , Kimberly Sepulveda , Sheldon B. Moberg
CPC classification number: A61M5/482 , A61M5/158 , A61M5/31576
Abstract: A drug delivery device includes a housing, a container disposed in the housing, a drive mechanism, a needle assembly, a fluid flow path, and a vortex flow adapter. The container contains a medicament which is urged out of the container by the drive mechanism. The needle assembly has a needle and/or a cannula to deliver the medicament from the container. The fluid flow path fluidically connects the container and the needle assembly. The vortex flow adapter is disposed within or defines at least a portion of the fluid flow path, and is adapted to urge the medicament to flow in a vortex pattern.
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公开(公告)号:US20220362462A1
公开(公告)日:2022-11-17
申请号:US17637507
申请日:2020-09-09
Applicant: AMGEN INC.
Inventor: Tohid Pirbodaghi , Paul Daniel Faucher , Joshua Tamsky , Scott Robert Gibson , Sheldon B. Moberg , Jeff Lind
Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle insertion mechanism, a fluid flow connection, and a valve in fluid communication with the fluid flow connection and the needle insertion mechanism. The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism is adapted to insert a needle and/or a cannula to deliver the medicament from the container via the fluid flow connection. The valve is in fluid communication with the fluid flow connection and needle insertion mechanism, and is movable between first and second positions. Upon insertion of the needle and/or the cannula, the valve remains in the first position whereby fluid flow is restricted. At a later time, the valve is urged to the second position whereby fluid may flow through the needle or cannula.
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公开(公告)号:US20220152304A1
公开(公告)日:2022-05-19
申请号:US17441021
申请日:2020-04-23
Applicant: AMGEN INC.
Inventor: Sheldon B. Moberg
Abstract: A drug delivery device assembly includes an injector body with a proximal end, a distal end, an outer surface, and a knob projecting from the outer surface. A needle assembly is at least partially disposed within the injector body. The needle assembly includes a syringe barrel containing a medicament and a needle or a cannula. A drive assembly is at least partially disposed within the injector body and operably coupled to the needle assembly to urge the medicament through the needle or cannula. An accessory defines a shell and has a proximal end, a distal end, a first opening at the proximal end sized to receive at least a portion of the injector body, and second opening at the distal end. The accessory surrounds a portion of the injector body when the accessory is coupled with the injector body.
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公开(公告)号:US20210316075A1
公开(公告)日:2021-10-14
申请号:US17196744
申请日:2021-03-09
Applicant: AMGEN INC
Inventor: Samin Akbari , Tohid Pirbodaghi , Sheldon B. Moberg
Abstract: Drug delivery devices and associated heating and/or cooling devices are disclosed. In an example, a drug delivery device includes a housing, a container, a therapy layer, and a first adhesive layer. The housing includes a top wall and a bottom wall. The container is at least partially disposed within the housing. The container has an inner volume to contain a drug. The therapy layer have a first side and a second side. The first side faces the bottom wall and the second side faces away from the bottom wall. The first adhesive layer couples the first side of the therapy layer and the bottom wall. The therapy layer is adapted to at least one of heat or cool an area adjacent an injection site.
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公开(公告)号:US20200316291A1
公开(公告)日:2020-10-08
申请号:US16089685
申请日:2017-04-07
Applicant: AMGEN INC.
Inventor: Scott Robert Gibson , Sheldon B. Moberg , Basel Hasan Taha , Margaux Frances Boyaval , Mark A. Destefano , Lawton Laurence , John C. Love , Ian B. Hanson , Paul F. Bente, IV , Matthew J. Clemente , Antonio Ubach , Rajan Ramaswamy , Daniel S. Codd , Scott Beaver , Kevin L. Bokelman , Ian P. Dardani , Sean M. O'connor , Danielle Feldman
Abstract: Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device includes a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector defines a sterile fluid flowpath between the container and the insertion mechanism. A cannula initially disposed about the needle is included.
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公开(公告)号:US12194280B2
公开(公告)日:2025-01-14
申请号:US17196744
申请日:2021-03-09
Applicant: AMGEN INC.
Inventor: Samin Akbari , Tohid Pirbodaghi , Sheldon B. Moberg
Abstract: Drug delivery devices and associated heating and/or cooling devices are disclosed. In an example, a drug delivery device includes a housing, a container, a therapy layer, and a first adhesive layer. The housing includes a top wall and a bottom wall. The container is at least partially disposed within the housing. The container has an inner volume to contain a drug. The therapy layer have a first side and a second side. The first side faces the bottom wall and the second side faces away from the bottom wall. The first adhesive layer couples the first side of the therapy layer and the bottom wall. The therapy layer is adapted to at least one of heat or cool an area adjacent an injection site.
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公开(公告)号:US11890450B2
公开(公告)日:2024-02-06
申请号:US16297408
申请日:2019-03-08
Applicant: AMGEN INC.
Inventor: Lawrence Scott Ring , Tohid Pirbodaghi , Samin Akbari , Daniel Eduardo Groszmann , Mehran Mojarrad , Mark Gordon , Mikhail Tikh , Jimmie L. Ward , Scott R. Gibson , Sheldon B. Moberg , Joshua Tamsky , Paul Faucher , Jeff Lind
CPC classification number: A61M5/16813 , A61M5/1413 , A61M5/14248 , A61M5/158 , A61M5/16822 , A61M39/24 , A61M5/14526 , A61M5/155 , A61M2005/1403 , A61M2005/1406 , A61M2005/14252 , A61M2039/244 , A61M2039/2406 , A61M2039/248 , A61M2039/2426 , A61M2205/3561 , A61M2205/505 , A61M2205/7527 , A61M2205/7536 , A61M2209/045
Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a container, a drive mechanism, a needle assembly, a fluid flow connection, and a backflow prevention mechanism. The container has an inner volume to contain a medicament to be administered to a user. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the medicament out the container. The fluid flow connection is coupled to the container and the needle assembly and allows the medicament to flow from the container to the needle assembly to be administered. The backflow prevention mechanism is associated with at least one of the container, the fluid flow connection, or the needle assembly and includes at least one flow restrictor to restrict a fluid from flowing from the needle assembly to the container.
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