公开(公告)号：US20190004034A1

公开(公告)日：2019-01-03

申请号：US16023045

申请日：2018-06-29

Applicant: AMOREPACIFIC CORPORATION

Inventor： Sunghoon LEE ,  Il-Hong BAE ,  Daejin MIN ,  Soojung OH ,  Tae Ryong LEE ,  Eungyung CHO

IPC: G01N33/50 ,  C12N5/071

Abstract: According to an embodiment, a method of producing artificial skin includes mixing fibroblasts and collagen to form a dermis simulating layer, applying keratinocytes on the dermis simulating layer and culturing the same, culturing the dermis simulating layer in a first medium that is a keratinocyte medium, and culturing the dermis simulating layer that is cultured in the first medium in a second medium including a DMEM medium and a F12 medium.

公开(公告)号：US20160106864A1

公开(公告)日：2016-04-21

申请号：US14883327

申请日：2015-10-14

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyung Jun LIM ,  Nok Hyun PARK ,  Yuri CHOI ,  Il-Hong BAE ,  Myeong Jin GOH ,  Jae Won YOU ,  Song Seok SHIN ,  Jon Hwan LEE

IPC: A61K47/48 ,  A61K8/64 ,  A61K9/107 ,  A61Q19/00 ,  A61K9/127 ,  A61K8/06 ,  A61K9/00 ,  A61K8/14

CPC classification number: A61K9/1075 ,  A61K8/0241 ,  A61K8/042 ,  A61K8/062 ,  A61K8/14 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/1271 ,  A61K9/1275 ,  A61K47/62 ,  A61K47/6911 ,  A61K2800/654 ,  A61Q1/02 ,  A61Q19/00 ,  A61Q19/10

Abstract: The present disclosure relates to a drug delivery carrier containing a lipid structure or a polymer particle which is covalently bonded to a cell-penetrating AP-GRR peptide (SEQ ID NO 1) or is modified with the peptide chain containing the peptide. The present disclosure also relates to a composition containing the drug delivery carrier and a physiologically active ingredient encapsulated in the carrier. The drug delivery carrier of the present disclosure can effectively deliver macromolecules that are difficult to be delivered into cells, thereby improving the bioavailability of the macromolecules.

Abstract translation: 本公开内容涉及含有脂质结构或聚合物颗粒的药物递送载体，其共价结合到细胞穿透性AP-GRR肽（SEQ ID NO 1）或用含有肽的肽链进行修饰。 本公开还涉及包含药物递送载体和包封在载体中的生理活性成分的组合物。 本公开的药物递送载体可以有效地递送难以递送到细胞中的大分子，从而提高大分子的生物利用度。