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    Methods of capture and assay procedures
    1.
    发明授权
    Methods of capture and assay procedures 失效
    捕获方法和测定程序

    公开(公告)号：US6159689A

    公开(公告)日：2000-12-12

    申请号：US74648

    申请日：1998-05-08

    Applicant: Adrian Parton

    Inventor： Adrian Parton

    IPC: G01N33/543 ,  C12Q1/68 ,  C12Q1/02 ,  G01N33/53 ,  G01N33/532 ,  G01N33/554

    CPC classification number: G01N33/54326 ,  B03C1/288 ,  B03C2201/26 ,  B03C2201/28 ,  Y10S436/806 ,  Y10S436/807

    Abstract: Methods of capturing and labeling a species, include attracting magnetically attractable particles to a solid support by magnetic forces, which particles have an affinity for the species, contacting the particles on the support with a sample containing the species to capture the species onto the particles on the support, and binding the species captured on the particles directly or indirectly to a detectable label before and/or whilst the species is captured on the particles on the support. The label may be bound to the captured species via an immunological binding partner which binds selectively to the species and may be a fluorescent label, luminescent label, enzyme label, dye label, phosphorescent label, metal-chelating label, radio label, spin label, heavy metal label, nucleic acid or nucleic acid analog hybridization label, avid or avid-like label suitably bound to or incorporated in particles which also bear a binding agent such as an antibody causing the particles to bind to the captured species.

    Abstract translation: 捕获和标记物种的方法包括通过磁力将可吸引的颗粒吸引到固体支持物上，该颗粒对该物质具有亲和力，使载体上的颗粒与含有物种的样品接触，以将物质捕获到颗粒上 支持物，并且在物种被捕获在载体上的颗粒之前和/或同时将在颗粒上捕获的物质直接或间接地结合到可检测标记。 标记可以通过免疫结合配偶体与选择性结合的物质结合到捕获的物种，并且可以是荧光标记，发光标记，酶标记，染料标记，磷光标记，金属螯合标记，无线标签，自旋标记， 重金属标记，核酸或核酸类似物杂交标记，适当地结合或掺入颗粒中的avid或avid样标记，其还具有结合剂，例如导致颗粒结合捕获物种的抗体。

    METHODS OF CAPTURING BINDABLE TARGETS FROM LIQUIDS
    2.
    发明申请
    METHODS OF CAPTURING BINDABLE TARGETS FROM LIQUIDS 审中-公开
    从液体中获取可结合目标的方法

    公开(公告)号：US20130344477A1

    公开(公告)日：2013-12-26

    申请号：US13979383

    申请日：2012-01-06

    Applicant: Adrian Parton

    Inventor： Adrian Parton

    IPC: C12Q1/24

    CPC classification number: C12Q1/24 ,  G01N33/54333

    Abstract: A bindable target such as a bacterial cell, virus, or molecule is captured from a liquid by contacting the liquid with magnetically attractable particles have an affinity for the target, and causing said particles to move repeatedly through said liquid to at least one solid support zone by attractive magnetic forces to capture the target onto said particles. The particles may be ferromagnetic, paramagnetic or superparamagnetic particles and may bear antibody, antibody binding fragments, a substance having an epitope capable of reacting in a specific manner with an antibody, an aptamer, a nucleic acid sequence or a nucleic acid analogue sequence, biotin, avidin or streptavidin. The particles may be moved back and forth in the liquid between separated solid support zones by attractive magnetic forces which attract the particles temporarily to different solid support zones in turn

    Abstract translation: 通过使液体与可磁性吸引的颗粒接触，从液体中捕获诸如细菌细胞，病毒或分子的可结合靶对靶标具有亲和力，并使所述颗粒重复地通过所述液体移动到至少一个固体支持区 通过有吸引力的磁力将靶捕获到所述颗粒上。 颗粒可以是铁磁性，顺磁性或超顺磁性颗粒，并且可以具有抗体，抗体结合片段，具有能够以特异性方式与抗体，适体，核酸序列或核酸类似物序列反应的表位的物质，生物素 ，抗生物素蛋白或链霉亲和素。 颗粒可以通过有吸引力的磁力在分离的固体支持区域之间的液体中来回移动，从而将颗粒暂时吸引到不同的固体支持区域

    SAMPLE PREPARATION DEVICE
    3.
    发明申请
    SAMPLE PREPARATION DEVICE 审中-公开
    样品制备装置

    公开(公告)号：US20120285267A1

    公开(公告)日：2012-11-15

    申请号：US13498104

    申请日：2010-09-20

    Applicant: Adrian Parton

    Inventor： Adrian Parton

    IPC: G01N1/28

    CPC classification number: B01L3/021 ,  B01L2300/0681 ,  B01L2300/123 ,  B01L2400/0487

    Abstract: A sample preparation device comprises:withdrawal means for withdrawing a sample from a liquid to be analysed; anda foam filter for filtering particulate material from the sample as the sample is withdrawn, the foam filter being mounted to the withdrawal means.

    Abstract translation: 样品制备装置包括：用于从要分析的液体中取出样品的抽出装置; 以及泡沫过滤器，用于在抽出样品时从样品中过滤颗粒材料，泡沫过滤器安装到抽出装置。

    Filtration and culture methods and apparatus
    5.
    发明授权
    Filtration and culture methods and apparatus 失效
    过滤和培养方法和装置

    公开(公告)号：US5905038A

    公开(公告)日：1999-05-18

    申请号：US976953

    申请日：1997-11-24

    Applicant: Adrian Parton

    Inventor： Adrian Parton

    IPC: C12M1/12 ,  C12M1/26 ,  C12Q1/24

    CPC classification number: B01L3/0275 ,  C12M25/02 ,  C12M33/14 ,  C12M47/02 ,  Y10T436/25375

    Abstract: A method and apparatus for filtering microorganisms from a sample and culturing the microorganisms employs a membrane filter (3) in a filter holder (10) in which holder the membrane filter is supported on an absorbent support (26) which is maintained in an expansible compressed state against the membrane filter so that any expansion of the membrane filter when wetted by a sample does not cause bubbling of the membrane filter away from its support entrapping air bubbles and so preventing supply of nutrient from culture medium supplied to the support from reaching the microorganisms on the membrane filter.

    Abstract translation: 用于从样品中过滤微生物并培养微生物的方法和装置在过滤器保持器（10）中使用膜过滤器（3），过滤器保持器（10）中的膜过滤器被支撑在吸收支撑件（26）上，所述吸收支撑件保持在可膨胀的压缩 以使得膜过滤器在被样品润湿时的任何膨胀不会使膜过滤器的气泡从其支持物捕获气泡引起，并且因此防止从提供给载体的培养基中提供营养物质达到微生物 在膜过滤器上。

    Methods of capturing species from liquids and assay procedures
    6.
    发明授权
    Methods of capturing species from liquids and assay procedures 失效
    从液体中捕获物种的方法和测定程序

    公开(公告)号：US5834197A

    公开(公告)日：1998-11-10

    申请号：US737296

    申请日：1996-11-08

    Applicant: Adrian Parton

    Inventor： Adrian Parton

    IPC: G01N33/543 ,  G01N33/553 ,  G01N33/569 ,  C12Q1/68

    CPC classification number: G01N33/56911 ,  G01N33/54326 ,  Y10S435/803 ,  Y10S436/806 ,  Y10S436/824

    Abstract: A species such as a microorganism, e.g. Legionella, Giardia or Cryptosporidium, is captured by first attracting plastic coated magneticbeads or other magnetically attractable particles to a solid support such as stainless steel mesh, which particles have a selective affinity for the species, e.g. by virtue of an antibody coating, and contacting a sample containing the species with the particles on the solid support. The beads bearing the captured species may be released by reduction of the magnetic attraction of the support for the beads, e.g. by turning off an electromagnet used to magnetize the support.

    Abstract translation: PCT No.PCT / GB95 / 01056 Sec。 371日期：1996年11月8日 102（e）日期1996年11月8日PCT提交1995年5月10日PCT公布。 出版物WO95 / 31726 日期：1995年11月23日。 军团病，贾第鞭毛虫或隐孢子虫，通过首先将塑料涂覆的磁珠或其它可磁吸引的颗粒吸引到诸如不锈钢网的固体支持物上，该颗粒对物种具有选择性亲和力。 通过抗体包被，并使包含该物种的样品与固体支持物上的颗粒接触。 携带捕获物种的珠可以通过减少珠的载体的磁吸引力来释放。 通过关闭用于磁化支架的电磁铁。

    Filtration method and apparatus
    7.
    发明授权
    Filtration method and apparatus 失效
    过滤方法和装置

    公开(公告)号：US5690825A

    公开(公告)日：1997-11-25

    申请号：US669278

    申请日：1996-06-20

    Applicant: Adrian Parton

    Inventor： Adrian Parton

    IPC: B01D29/05 ,  B01D39/16 ,  B01D39/00 ,  B01D29/58 ,  B01D29/78 ,  G01N33/569

    CPC classification number: B01D29/055 ,  B01D39/1676 ,  B01D2201/06

    Abstract: An expansible, compressed foam is used a s a filter medium and captured particulates are released from the foam by expanding the foam to open its pores. Micro-organisms such as Cryptosporidium or Giardia cysts may be trapped and recovered at high eficiency in a small volume of wash liquid easing further analysis. A foam filter element comprises thirty discs (36) of retriculated foam compressed between end plates (28,30) to about one tenth of their original thickness.

    Abstract translation: PCT No.PCT / GB94 / 02782 Sec。 371日期：1996年6月20日 102（e）1996年6月20日PCT 1994年12月21日PCT PCT。 WO95 / 17238 PCT公开号 日期1995年6月29日可膨胀的压缩泡沫使用过滤介质，捕获的颗粒通过膨胀泡沫以从孔中释放出孔。 微生物如隐孢子虫或贾第虫囊肿可能会以高效率被捕获和回收，在少量洗涤液中进一步分析。 泡沫过滤元件包括压缩在端板（28,30）之间的三分之一（36）的重质泡沫，至其原始厚度的约十分之一。

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