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53 条记录 (耗时 0.024 秒)

    Delayed onset transdermal delivery device
    1.
    发明授权
    Delayed onset transdermal delivery device 失效
    延迟发作透皮递送装置

    公开(公告)号：US5284660A

    公开(公告)日：1994-02-08

    申请号：US933423

    申请日：1992-08-21

    申请人： Eun Soo Lee ,  Felix Theeuwes ,  Patrick S. L. Wong ,  Su Il Yum ,  Robert M. Gale ,  Alejandro Zaffaroni

    发明人： Eun Soo Lee ,  Felix Theeuwes ,  Patrick S. L. Wong ,  Su Il Yum ,  Robert M. Gale ,  Alejandro Zaffaroni

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/70 ,  A61F13/00

    CPC分类号： A61K9/7084 ,  A61K9/7069 ,  A61K9/7092

    摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.

    摘要翻译： 描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。 在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。 合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。 可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。 延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

    Delayed onset transdermal delivery device
    2.
    发明授权
    Delayed onset transdermal delivery device 失效
    延迟发作透皮递送装置

    公开(公告)号：US5071656A

    公开(公告)日：1991-12-10

    申请号：US271207

    申请日：1988-11-14

    申请人： Eun Soo Lee ,  Felix Theeuwes ,  Patrick S. L. Wong ,  Su Il Yum ,  Alejandro Zaffaroni

    发明人： Eun Soo Lee ,  Felix Theeuwes ,  Patrick S. L. Wong ,  Su Il Yum ,  Alejandro Zaffaroni

    IPC分类号： A61K9/70 ,  A61K31/21

    CPC分类号： A61K9/7069 ,  A61K31/21 ,  A61K9/7084 ,  A61K9/7092

    摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal pattern at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.

    摘要翻译： 描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。 在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。 合适的方法包括设置在释放表面和试剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初对试剂不渗透，然后变为可渗透的。 可以提供由一个或多个这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。 延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

    Active agent dispenser
    3.
    发明授权
    Active agent dispenser 失效
    活性剂分配器

    公开(公告)号：US4564364A

    公开(公告)日：1986-01-14

    申请号：US498381

    申请日：1983-05-26

    申请人： Alejandro Zaffaroni ,  Patrick S. L. Wong

    发明人： Alejandro Zaffaroni ,  Patrick S. L. Wong

    IPC分类号： B01J4/00 ,  A61K9/20 ,  A61K9/26 ,  A61K9/70 ,  A61M31/00 ,  A61F15/00

    CPC分类号： A61K9/7023 ,  A61K9/2086 ,  A61M31/002 ,  A61F2013/0296

    摘要： The release pattern of a dispersion type active agent dispenser can be improved by forming the device from a depleted zone containing the agent at a concentration no greater than the saturation and a non-depleted zone containing the agent dispersed in the matrix at a uniform concentration greater than saturation. The depleted zone is disposed between the surface through which the agent is to be dispensed and at least a substantial portion of the non-depleted zone with the interface therebetween disposed at a non-uniform distance from the releasing surface. Certain embodiments are particularly useful for the transdermal administration of drugs.

    摘要翻译： 分散型活性剂分配器的释放模式可以通过从不含饱和度的含有试剂的贫化区形成装置，并且以均匀的浓度将含有分散在基质中的试剂的非贫化区形成， 比饱和度。 耗尽区设置在待分配试剂的表面和至少大部分的非耗尽区之间，其间的界面设置在与释放表面不均匀的距离处。 某些实施方案对于透皮给药药物特别有用。

    Potassium replacement therapy
    10.
    发明授权
    Potassium replacement therapy 失效
    钾替代疗法

    公开(公告)号：US4352791A

    公开(公告)日：1982-10-05

    申请号：US257540

    申请日：1981-04-27

    申请人： Alejandro Zaffaroni ,  John Fara

    发明人： Alejandro Zaffaroni ,  John Fara

    IPC分类号： A61K33/14 ,  A61K31/60

    CPC分类号： A61K33/14

    摘要： A composition is disclosed comprising potassium chloride and a therapeutically acceptable salicylate salt or salicylic acid. The composition is useful for potassium therapy.

    摘要翻译： 公开了包含氯化钾和治疗上可接受的水杨酸盐或水杨酸的组合物。 该组合物可用于钾疗法。