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公开(公告)号：US08133983B2
公开(公告)日：2012-03-13
申请号：US12383330
申请日：2009-03-23
申请人： Alexander Berthold Hendrik Bakker , Pauline Marie Louise Meester-Rood , Adrianus Quirinus Bakker
发明人： Alexander Berthold Hendrik Bakker , Pauline Marie Louise Meester-Rood , Adrianus Quirinus Bakker
IPC分类号： C07K16/30 , C12P21/08 , A61K39/395 , C12P21/06
CPC分类号： A61K31/00 , A61K49/0058 , A61K51/1027 , A61K2039/505 , C07K16/2878 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/74 , C07K2319/00 , C07K2319/30 , G01N33/564 , G01N33/6893 , G01N2333/70578 , G01N2500/00
摘要： The present invention provides binding molecules, such as human binding molecules, that bind to and stimulate the human OX40-receptor. The invention also provides nucleic acids encoding such binding molecules. Methods for producing such binding molecules are also provided by the present invention. The binding molecules and nucleic acids are useful in the stimulation of human T-cells and can be used to enhance antigen-specific immune responses.
摘要翻译： 本发明提供结合并刺激人OX40-受体的结合分子，例如人结合分子。 本发明还提供了编码这种结合分子的核酸。 本发明还提供了生产这种结合分子的方法。 结合分子和核酸可用于刺激人类T细胞，并可用于增强抗原特异性免疫应答。
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公开(公告)号：US20110123552A1
公开(公告)日：2011-05-26
申请号：US12383330
申请日：2009-03-23
申请人： Alexander Berthold Hendrik Bakker , Pauline Marie Louise Meester-Rood , Adrianus Quirinus Bakker
发明人： Alexander Berthold Hendrik Bakker , Pauline Marie Louise Meester-Rood , Adrianus Quirinus Bakker
CPC分类号： A61K31/00 , A61K49/0058 , A61K51/1027 , A61K2039/505 , C07K16/2878 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/74 , C07K2319/00 , C07K2319/30 , G01N33/564 , G01N33/6893 , G01N2333/70578 , G01N2500/00
摘要： The present invention provides binding molecules, such as human binding molecules, that bind to and stimulate the human OX40-receptor. The invention also provides nucleic acids encoding such binding molecules. Methods for producing such binding molecules are also provided by the present invention. The binding molecules and nucleic acids are useful in the stimulation of human T-cells and can be used to enhance antigen-specific immune responses.
摘要翻译： 本发明提供结合并刺激人OX40-受体的结合分子，例如人结合分子。 本发明还提供了编码这种结合分子的核酸。 本发明还提供了生产这种结合分子的方法。 结合分子和核酸可用于刺激人类T细胞，并可用于增强抗原特异性免疫应答。
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公开(公告)号：US07550140B2
公开(公告)日：2009-06-23
申请号：US10517941
申请日：2003-06-13
申请人： Alexander Berthold Hendrik Bakker , Pauline Marie Louise Meester-Rood , Adrianus Quirinus Bakker
发明人： Alexander Berthold Hendrik Bakker , Pauline Marie Louise Meester-Rood , Adrianus Quirinus Bakker
IPC分类号： A61K39/395 , A61K39/00 , A61K38/00 , C12N5/02 , C12N5/06
CPC分类号： A61K31/00 , A61K49/0058 , A61K51/1027 , A61K2039/505 , C07K16/2878 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/74 , C07K2319/00 , C07K2319/30 , G01N33/564 , G01N33/6893 , G01N2333/70578 , G01N2500/00
摘要： The present invention provides binding molecules, such as human binding molecules, that bind to and stimulate the human OX40-receptor. The invention also provides nucleic acids encoding such binding molecules. Methods for producing such binding molecules are also provided by the present invention. The binding molecules and nucleic acids are useful in the stimulation of human T-cells and can be used to enhance antigen-specific immune responses.
摘要翻译： 本发明提供结合并刺激人OX40-受体的结合分子，例如人结合分子。 本发明还提供了编码这种结合分子的核酸。 本发明还提供了生产这种结合分子的方法。 结合分子和核酸可用于刺激人类T细胞，并可用于增强抗原特异性免疫应答。
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4.发明申请公开(公告)号：US20080226652A1
公开(公告)日：2008-09-18
申请号：US11978742
申请日：2007-10-29
申请人： Alexander Berthold Hendrik Bakker , Willem Egbert Marissen , Robert Arjen Kramer , Cornelis Adriaan De Kruif
发明人： Alexander Berthold Hendrik Bakker , Willem Egbert Marissen , Robert Arjen Kramer , Cornelis Adriaan De Kruif
IPC分类号： A61K39/395 , A61P43/00
CPC分类号： C07K16/10 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N2760/20122 , G01N33/56983
摘要： Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. In certain embodiments, they can be used in the post-exposure prophylaxis of rabies.
摘要翻译： 提供特异性结合狂犬病病毒并能够中和病毒的结合分子。 还提供了编码结合分子的核酸分子，包含结合分子的组合物以及鉴定或产生结合分子的方法。 结合分子可用于诊断，预防和/或治疗由狂犬病病毒引起的病症。 在某些实施方案中，它们可以用于狂犬病的暴露后预防。
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5.发明授权公开(公告)号：US09005624B2
公开(公告)日：2015-04-14
申请号：US12798748
申请日：2010-04-08
申请人： Alexander Berthold Hendrik Bakker , Willem Egbert Marissen , Robert Arjen Kramer , Cornelis Adriaan De Kruif
发明人： Alexander Berthold Hendrik Bakker , Willem Egbert Marissen , Robert Arjen Kramer , Cornelis Adriaan De Kruif
IPC分类号： A61K39/395 , A61P31/14 , C07K16/10 , C07K14/005 , G01N33/569 , A61K39/00
CPC分类号： C07K16/10 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N2760/20122 , G01N33/56983
摘要： Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. In certain embodiments, they can be used in the post-exposure prophylaxis of rabies.
摘要翻译： 提供特异性结合狂犬病病毒并能够中和病毒的结合分子。 还提供了编码结合分子的核酸分子，包含结合分子的组合物以及鉴定或产生结合分子的方法。 结合分子可用于诊断，预防和/或治疗由狂犬病病毒引起的病症。 在某些实施方案中，它们可以用于狂犬病的暴露后预防。
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公开(公告)号：US20120270802A1
公开(公告)日：2012-10-25
申请号：US13474456
申请日：2012-05-17
申请人： Sonja van den Oudenrijn , Marja van Meijer , Adrianns Q. Bakker , Alexander Berthold Hendrik Bakker
发明人： Sonja van den Oudenrijn , Marja van Meijer , Adrianns Q. Bakker , Alexander Berthold Hendrik Bakker
CPC分类号： C07K14/705 , A61K2039/505 , C07K14/7056 , C07K16/2851 , C07K16/3061 , C07K16/3076 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/622 , C07K2317/77 , C07K2319/00
摘要： Provided is a human C-type lectin, binding molecules that specifically bind to the human C-type lectin, nucleic acid molecules encoding the binding molecules or the human C-type lectin, compositions comprising the binding molecules or the human C-type lectin and methods of identifying or producing the binding molecules. The human C-type lectin is specifically expressed on myeloid cells and binding molecules capable of specifically binding to the human C-type lectin can be used in the diagnosis, prevention, and/or treatment of neoplastic disorders and diseases.
摘要翻译： 本发明提供了人C型凝集素，与人C型凝集素特异性结合的结合分子，编码结合分子的核酸分子或人C型凝集素，包含结合分子或人C型凝集素的组合物，以及 识别或产生结合分子的方法。 人类C型凝集素特异性表达于骨髓细胞，能够特异性结合人C型凝集素的结合分子可用于诊断，预防和/或治疗肿瘤性疾病和疾病。
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公开(公告)号：US20100184671A1
公开(公告)日：2010-07-22
申请号：US12653779
申请日：2009-12-18
申请人： Sonja van den Oudenrijn , Marja van Meijer , Adrianus Q. Bakker , Alexander Berthold Hendrik Bakker
发明人： Sonja van den Oudenrijn , Marja van Meijer , Adrianus Q. Bakker , Alexander Berthold Hendrik Bakker
IPC分类号： A61K38/17 , C07H21/04 , C07K14/47 , C07K16/46 , C07K16/18 , A61P35/00 , C12N15/00 , C12N5/10 , C12P21/06 , C40B40/06 , G01N33/566 , G01N33/567
CPC分类号： C07K14/705 , A61K2039/505 , C07K14/7056 , C07K16/2851 , C07K16/3061 , C07K16/3076 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/622 , C07K2317/77 , C07K2319/00
摘要： Provided is a human C-type lectin, binding molecules that specifically bind to the human C-type lectin, nucleic acid molecules encoding the binding molecules or the human C-type lectin, compositions comprising the binding molecules or the human C-type lectin and methods of identifying or producing the binding molecules. The human C-type lectin is specifically expressed on myeloid cells and binding molecules capable of specifically binding to the human C-type lectin can be used in the diagnosis, prevention and/or treatment of neoplastic disorders and diseases.
摘要翻译： 本发明提供了人C型凝集素，与人C型凝集素特异性结合的结合分子，编码结合分子的核酸分子或人C型凝集素，包含结合分子或人C型凝集素的组合物，以及 识别或产生结合分子的方法。 人类C型凝集素在骨髓细胞上特异性表达，能够特异性结合人C型凝集素的结合分子可用于诊断，预防和/或治疗肿瘤性疾病和疾病。
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公开(公告)号：US07741443B2
公开(公告)日：2010-06-22
申请号：US11317786
申请日：2005-12-22
申请人： Sonja van den Oudenrijn , Marja van Meijer , Adrianus Q. Bakker , Alexander Berthold Hendrik Bakker
发明人： Sonja van den Oudenrijn , Marja van Meijer , Adrianus Q. Bakker , Alexander Berthold Hendrik Bakker
IPC分类号： C07K16/00 , C07K17/00 , G01N33/53 , A61K39/395
CPC分类号： C07K14/705 , A61K2039/505 , C07K14/7056 , C07K16/2851 , C07K16/3061 , C07K16/3076 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/622 , C07K2317/77 , C07K2319/00
摘要： The present invention provides a human C-type lectin, binding molecules that specifically bind to the human C-type lectin, nucleic acid molecules encoding the binding molecules or the human C-type lectin, compositions comprising the binding molecules or the human C-type lectin and methods of identifying or producing the binding molecules. The human C-type lectin is specifically expressed on myeloid cells and binding molecules capable of specifically binding to the human C-type lectin can be used in the diagnosis, prevention and/or treatment of neoplastic disorders and diseases.
摘要翻译： 本发明提供人C型凝集素，与人C型凝集素特异性结合的结合分子，编码结合分子的核酸分子或人C型凝集素，包含结合分子或人C型凝集素的组合物 凝集素和鉴定或产生结合分子的方法。 人类C型凝集素在骨髓细胞上特异性表达，能够特异性结合人C型凝集素的结合分子可用于诊断，预防和/或治疗肿瘤性疾病和疾病。
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9.发明授权公开(公告)号：US08148497B2
公开(公告)日：2012-04-03
申请号：US12459661
申请日：2009-07-06
申请人： Alexander Berthold Hendrik Bakker , Willem Egbert Marissen , Robert Arjen Kramer , Cornelis Adriaan de Kruif
发明人： Alexander Berthold Hendrik Bakker , Willem Egbert Marissen , Robert Arjen Kramer , Cornelis Adriaan de Kruif
CPC分类号： C07K16/10 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N2760/20122 , G01N33/56983
摘要： The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. Preferably, they can be used in the post-exposure prophylaxis of rabies.
摘要翻译： 本发明提供了特异性结合狂犬病毒并能够中和病毒的结合分子。 本发明还提供了编码结合分子的核酸分子，包含结合分子的组合物以及鉴定或产生结合分子的方法。 结合分子可用于诊断，预防和/或治疗由狂犬病病毒引起的病症。 优选地，它们可用于狂犬病的暴露后预防。
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公开(公告)号：US07740852B2
公开(公告)日：2010-06-22
申请号：US11978742
申请日：2007-10-29
申请人： Alexander Berthold Hendrik Bakker , Willem Egbert Marissen , Robert Arjen Kramer , Cornelis Adriaan De Kruif
发明人： Alexander Berthold Hendrik Bakker , Willem Egbert Marissen , Robert Arjen Kramer , Cornelis Adriaan De Kruif
IPC分类号： A61K39/42
CPC分类号： C07K16/10 , A61K2039/505 , A61K2039/507 , C07K14/005 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C12N2760/20122 , G01N33/56983
摘要： Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. In certain embodiments, they can be used in the post-exposure prophylaxis of rabies.
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