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公开(公告)号：US20180224422A1
公开(公告)日：2018-08-09
申请号：US15712552
申请日：2017-09-22
Inventor： Stuart LINDSAY , Shuai CHANG , Jin HE , Peiming ZHANG , Shuo HUANG
IPC: G01N33/487 , G01N27/327 , C12Q1/6869
CPC classification number: G01N33/48721 , C12Q1/6869 , G01N27/3275 , Y10T436/143333
Abstract: The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.
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公开(公告)号：US20170343558A1
公开(公告)日：2017-11-30
申请号：US15672437
申请日：2017-08-09
Inventor： Stuart LINDSAY , Peiming ZHANG , Sudipta BISWAS
IPC: G01N33/68 , G01N33/487 , C07K1/107
CPC classification number: G01N33/6818 , C07K1/107 , G01N33/48721
Abstract: Embodiments disclosed herein are directed to recognition tunneling systems, methods and devices, and more particularly, to chemical reactions for selectively labeling proteins and peptides and placing protein and/or peptides into, or onto a nanopore formed in a solid support and threading such in and/or through the nanopore, with such nanopores, in some embodiments, including a molecular motor to pull or otherwise force the protein/peptide through the nanopore.
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公开(公告)号：US20170137389A1
公开(公告)日：2017-05-18
申请号：US15308517
申请日：2015-05-07
Inventor： Peiming ZHANG , Stuart LINDSAY , Saikat MANNA , Subhadip SENAPATI
IPC: C07D249/06 , C12N15/115 , C07K14/00 , C07D487/04 , C07C247/04
CPC classification number: C07D249/06 , C07C247/04 , C07D249/04 , C07D487/04 , C07D491/052 , C07K14/001 , C12N15/115 , C12N2310/16 , C12N2310/3517
Abstract: Some of the embodiments of the present disclosure relate to a compound of the formula, and methods of preparing and using same.
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公开(公告)号：US20250002990A1
公开(公告)日：2025-01-02
申请号：US18709791
申请日：2022-11-14
Inventor： Quan QING , Peiming ZHANG
IPC: C12Q1/6869 , G16B30/00 , G16B40/10
Abstract: Disclosed are a nanopore-optical electronic device and a method for sequencing a biomolecule and modifications thereof. The nanopore-optical electronic device includes: a cis-fluidic chamber and a trans-fluidic chamber fabricated in a planar substrate; a nano-fluidic channel in between and connecting the cis-fluidic chamber and the trans-fluidic chamber; a first electrode and a second electrode sealed in the nano-fluidic channel and forming a nanogap/nanopore therebetween; a third electrode and fourth electrode disposed in the cis-fluidic chamber and the trans-fluidic chamber, respectively; an optical coupling element coupling an electromagnetic beam with the nanogap; an optical detector detecting an optical signal from the nanogap when a biomolecule translocates through the nanopore; and a current-measuring circuit concurrently measuring a tunneling current and ionic current when the biomolecule translocates through the nanopore. The recorded optical signal and tunneling current and ionic current signals are coincidental in time and colocalized in space.
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公开(公告)号：US20170204066A1
公开(公告)日：2017-07-20
申请号：US15417903
申请日：2017-01-27
Inventor： Stuart LINDSAY , Peiming ZHANG
IPC: C07D235/24 , G01N33/487 , G01N27/447 , C12Q1/68
CPC classification number: C07D235/24 , C12Q1/6869 , G01N27/447 , G01N27/44791 , G01N33/48721 , C12Q2565/631
Abstract: The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
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Patent Agency Ranking
公开(公告)号：US20170003245A1
公开(公告)日：2017-01-05
申请号：US15203383
申请日：2016-07-06
Inventor： Stuart LINDSAY , Peiming ZHANG
IPC: G01N27/327 , G01N33/487 , C12Q1/68 , G01N27/02
CPC classification number: G01N27/3278 , C12Q1/6869 , G01N27/028 , G01N27/3276 , G01N33/48721 , C12Q2565/631
Abstract: An system for recognition of a translocating polymetric target molecule includes a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. A pair of spaced apart sensing electrodes border the constriction, which may be a nonopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. Each affinity element may connected to its corresponding electrode via one or more intermediary compounds, such as a linker molecule and/or an electrode attachment molecule. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction. During translocation, the electrodes affinity elements and first and second portions of the target molecule complete an electrical circuit and allow a measurable electrical current to pass between the first and second electrodes. The time-varying nature of this electrical current, and the specific affinity elements employed, allow one to characterize the target molecule.
Abstract translation: 用于识别易位多分子靶分子的系统包括具有至少一个收缩部的装置，其尺寸被确定为允许仅分解单个拷贝的易位。 一对间隔开的感应电极与收缩部分相邻，其可以是非孔。 第一电极连接到第一亲和元件，第二电极连接到第二亲和元件。 每个亲和元件可以经由一种或多种中间化合物，例如连接体分子和/或电极附着分子连接到其对应的电极。 第一和第二亲和元件配置成与靶分子的第一和第二部分暂时形成氢键，因为它们经过收缩部。 在易位期间，电极亲和元件和目标分子的第一和第二部分完成电路并允许可测量的电流在第一和第二电极之间通过。 该电流的随时间变化特性以及所使用的特异亲和元件允许表征靶分子。
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公开(公告)号：US20190317040A1
公开(公告)日：2019-10-17
申请号：US16389859
申请日：2019-04-19
Inventor： Stuart LINDSAY , Peiming ZHANG
IPC: G01N27/327 , C12Q1/6869 , G01N27/02 , G01N33/487
Abstract: An system for recognition of a translocating polymeric target molecule includes a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. A pair of spaced apart sensing electrodes border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. Each affinity element may be connected to its corresponding electrode via one or more intermediary compounds, such as a linker molecule and/or an electrode attachment molecule. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction. During translocation, the electrodes, affinity elements and first and second portions of the target molecule complete an electrical circuit and allow a measurable electrical current to pass between the first and second electrodes. The time-varying nature of this electrical current, and the specific affinity elements employed, allow one to characterize the target molecule.
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8.发明申请公开(公告)号：US20190242885A1
公开(公告)日：2019-08-08
申请号：US16174933
申请日：2018-10-30
Inventor： Stuart LINDSAY , Peiming ZHANG , Pei PANG
IPC: G01N33/543 , G01N33/487 , B01L3/00
CPC classification number: G01N33/5438 , B01L3/502715 , B01L3/502761 , B01L2200/10 , B01L2300/0645 , B01L2300/0861 , B01L2300/0887 , G01N33/48721
Abstract: A sensing device is provided that includes a tunnel junction created by forming a hole in a layered tunnel junction (for example). A chemically, well-defined surface may be formed by coupling affinity reagents to the electrodes, which, by these means, the surface may be configured to be selective for a particular analyte.
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公开(公告)号：US20180209953A1
公开(公告)日：2018-07-26
申请号：US15922436
申请日：2018-03-15
Inventor： Stuart LINDSAY , Peiming ZHANG
IPC: G01N33/487 , G01N33/68 , G01N15/12 , G01N27/447 , C12Q1/37 , G01N33/543
CPC classification number: G01N33/48721 , C12Q1/37 , G01N15/12 , G01N27/44704 , G01N27/44747 , G01N27/44756 , G01N33/5438 , G01N33/6803 , G01N33/6848 , G01N2333/952 , G01N2570/00 , Y10T436/255
Abstract: Embodiments of the present disclosure are directed to methods, systems and devices, for analyzing the molecules. For example, in some embodiments, a system is provided which includes a first volume of conducting fluid, a second volume of conducting fluid, an orifice in communication with said first and second volumes of fluid, and means for applying an electric potential difference between said first and second volumes of fluid. In some such embodiments, a conjugate product is provided which comprises charged polymers each having attached thereto at least one first molecule for analysis, where the product carries a predetermined charge greater than the charge on the first molecule, and upon dissolving a product in the first volume of fluid, the product is directed into the orifice.
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公开(公告)号：US20180120286A1
公开(公告)日：2018-05-03
申请号：US15797052
申请日：2017-10-30
Inventor： Stuart LINDSAY , Peiming ZHANG , Yanan ZHAO
IPC: G01N33/487 , G01N27/447
Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length L1 and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than 2L1, but less than or equal to the sum of 2L1 and L2.
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