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公开(公告)号：US10273485B2
公开(公告)日：2019-04-30
申请号：US15116600
申请日：2015-02-06
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth , Christoph Wittmann , René Stellmacher , Judith Becker
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
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2.发明授权Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans 有权能够产生β-葡聚糖的转基因微生物和生产β-葡聚糖的方法公开(公告)号：US09322041B2
公开(公告)日：2016-04-26
申请号：US13935043
申请日：2013-07-03
Applicant: BASF SE , Wintershall Holding GmbH
Inventor： Beata Brockmann , Andrea Herold , Oskar Zelder , Stefan Haefner , Christian Fleck , Hartwig Schröder , Mari Granström , Julia Kristiane Schmidt
CPC classification number: C12P19/04 , C08B37/0024 , C08L5/00 , C12N9/1051 , C12N15/80 , C12P19/18 , C12Y204/01034 , Y02P20/52
Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-β-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity or the use of such a polypeptide for producing β-glucans. Furthermore, the present invention relates to methods for producing β-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity thereby increasing the expression of the polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-β-D-glucan synthase-activity into a microorganism being able to synthesize β-glucans.
Abstract translation: 本发明涉及能够产生β-葡聚糖的转基因微生物，其特征在于，遗传修饰的微生物过表达（i）编码具有1,3-葡聚糖合酶活性的多肽的多核苷酸和/或（ ii）与相同菌株的相应未修饰的对照微生物相比，具有1,3-葡聚糖 - D-葡聚糖合酶活性的多肽。 本发明还涉及编码具有1,3-葡萄糖 - D-葡聚糖合酶活性的多肽的多核苷酸的用途或这种多肽用于生产葡聚糖的用途。 此外，本发明涉及生产葡聚糖的方法，包括在编码具有1,3-葡萄糖-D-葡聚糖合酶活性的多肽的多核苷酸上游引入启动子，从而增加多核苷酸的表达，或 编码具有1,3-葡聚糖合酶活性的多肽的多核苷酸能够合成葡聚糖。
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公开(公告)号：US10287558B2
公开(公告)日：2019-05-14
申请号：US15116669
申请日：2015-02-02
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth , Christoph Wittmann , René Stellmacher , Judith Becker , Anna Lange , Benjamin J. Lyons , Thomas J. Lyons , Eudes De Crecy , Ewa Hughes
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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公开(公告)号：US10047364B2
公开(公告)日：2018-08-14
申请号：US15024464
申请日：2014-09-11
Applicant: BASF SE
Inventor： Hartwig Schröder , Holger Hartmann , Qingzhao Wang , Shakir Ratani , Zheyuan Guo , Markus Pompejus
IPC: C12N1/20 , C12N15/70 , C07K14/245 , C12P13/06 , C12P7/46 , C12N9/02 , C12N9/16 , C12P7/40 , C12P7/56 , C12P13/08 , C12P13/20
Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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公开(公告)号：US09932612B2
公开(公告)日：2018-04-03
申请号：US14676317
申请日：2015-04-01
Applicant: BASF SE
Inventor： Hartwig Schröder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
CPC classification number: C12P7/46 , C12N1/32 , C12N9/1029 , C12R1/01 , C12Y203/01054
Abstract: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
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Patent Agency Ranking
公开(公告)号：US09796992B2
公开(公告)日：2017-10-24
申请号：US14084030
申请日：2013-11-19
Applicant: BASF SE
Inventor： Oskar Zelder , Birgit Hoff , Hartwig Schröder , Andrea Molt , Holger Hartmann , Klaus Ditrich , Michael Breuer , Rüdiger Reingruber , Jakob Weber
Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
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公开(公告)号：US20170166937A1
公开(公告)日：2017-06-15
申请号：US15116896
申请日：2015-05-02
Applicant: BASF SE
Inventor： Joanna Martyna Krawczyk , Stefan Haefner , Hartwig Schröder , Esther Dantas Costa , Oskar Zelder , Gregory Von Abendroth
IPC: C12P7/46
CPC classification number: C12P7/46 , C07K14/285 , C12N1/20 , C12N15/52
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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公开(公告)号：US20140242704A1
公开(公告)日：2014-08-28
申请号：US14272781
申请日：2014-05-08
Applicant: BASF SE
Inventor： Oskar Zelder , Corinna Klopprogge , Burkhard Kröger , Hartwig Schröder , Stefan Haefner
IPC: C12N15/63
Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
Abstract translation: 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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公开(公告)号：US20190119710A1
公开(公告)日：2019-04-25
申请号：US16235511
申请日：2018-12-28
Applicant: BASF SE
Inventor： Hartwig Schröder , Holger Hartmann , Qingzhao Wang , Shakir Siraj Ratani , Zheyuan Guo , Markus Pompejus
IPC: C12P13/06 , C12P13/20 , C12P13/08 , C12P7/56 , C12P7/46 , C12N9/06 , C12N1/20 , C07K14/245 , C12P7/04
Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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公开(公告)号：US10208324B2
公开(公告)日：2019-02-19
申请号：US15103045
申请日：2014-12-08
Applicant: BASF SE
Inventor： Hartwig Schröder , Holger Hartmann , Qingzhao Wang , Shakir Ratani , Zheyuan Guo , Markus Pompejus
IPC: C12N15/31 , C12P13/06 , C07K14/245 , C12N1/20 , C12N9/06 , C12P7/04 , C12P7/46 , C12P7/56 , C12P13/08 , C12P13/20
Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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