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    METHODS FOR PRODUCTION OF A TERPENE AND A CO-PRODUCT
    2.
    发明申请
    METHODS FOR PRODUCTION OF A TERPENE AND A CO-PRODUCT 审中-公开
    一种生产方法和一种副产品

    公开(公告)号：US20150211024A1

    公开(公告)日：2015-07-30

    申请号：US14423787

    申请日：2013-08-28

    Applicant: Braskem S.A.

    Inventor： Mateus Schreiner Garcez Lopes ,  Avram Michael Slovic

    IPC: C12P5/00 ,  C12P7/18 ,  C12P7/04 ,  C12P7/46

    CPC classification number: C12P5/007 ,  C12N15/52 ,  C12P7/04 ,  C12P7/18 ,  C12P7/46

    Abstract: The present disclosure generally relates to microorganisms (e.g., non-naturally occurring microorganisms) that comprise one or more polynucleotides coding for enzymes in a pathway that catalyze a conversion of a carbon source (e.g., a fermentable carbon source) to terpene and a co-product such as succinate, 1,3-butanediol, or crotonyl alcohol and the use of such microorganisms for the production of terpene and a co-product such as succinate, 1,3-butanediol, or crotonyl alcohol.

    Abstract translation: 本公开一般涉及包含一种或多种编码酶的多核苷酸的微生物（例如非天然存在的微生物），所述多核苷酸在催化碳源（例如，可发酵碳源）转化为萜烯的途径中， 产品如琥珀酸酯，1,3-丁二醇或巴豆醇，以及这些微生物用于生产萜烯和共产物如琥珀酸酯，1,3-丁二醇或巴豆醇的用途。

    MODIFIED MICROORGANISM AND METHODS OF USING SAME FOR PRODUCING BUTADIENE AND 1-PROPANOL AND/OR 1,2-PROPANEDIOL
    3.
    发明申请
    MODIFIED MICROORGANISM AND METHODS OF USING SAME FOR PRODUCING BUTADIENE AND 1-PROPANOL AND/OR 1,2-PROPANEDIOL 审中-公开
    改良的微生物及其生产丁二酸和1-丙醇和/或1,2-丙二醇的方法

    公开(公告)号：US20150064760A1

    公开(公告)日：2015-03-05

    申请号：US14479071

    申请日：2014-09-05

    Applicant: BRASKEM S.A.

    Inventor： Johana Rincones Perez ,  Juan Diego Rojas Rojas ,  Ane Fernanda Beraldi Zeidler ,  Aline Silva Romao Dumaresq ,  Marilene Elizabete Pavan Rodrigues ,  Iuri Estrada Gouvea ,  Felipe Galzerani ,  Daniel Johannes Koch ,  Lucas Pedersen Parizzi ,  Mateus Schreiner Garcez Lopes ,  Thomas Martin Halder ,  Antonio Luis Ribeiro De Castro Morschbacker ,  Avram Michael Slovic

    IPC: C12P5/02 ,  C12P7/04 ,  C12P7/18 ,  C12N15/63

    CPC classification number: C12P7/18 ,  C07K14/395 ,  C12N15/63 ,  C12P5/026 ,  C12P7/04

    Abstract: The present disclosure provides a non-naturally occurring microorganism comprising: one or more polynucleotides encoding one or more enzymes in a pathway that produces acetyl-CoA; one or more polynucleotides encoding one or more enzymes in a pathway that catalyze a conversion of crotonyl alcohol, 5-hydroxy-3-ketovaleryl-CoA, 3-ketopent-4-enoyl-CoA, or 3,5-ketovaleryl-CoA to butadiene; one or more polynucleotides encoding one or more enzymes in a pathway that catalyze a conversion of dihydroxyacetone-phosphate to 1-propanol and/or 1,2-propanediol, wherein the microorganism has reduced levels of pyruvate decarboxylase enzymatic activity (e.g., the microorganism comprises a disruption of one or more enzymes that decarboxylate pyruvate and/or a disruption of one or more transcription factors of one or more enzymes that decarboxylate pyruvate), and wherein the microorganism is capable of growing on a C6 sugar as a sole carbon source under anaerobic conditions. Also provided are methods of using the disclosed non-naturally occurring microorganisms in methods for the coproduction of butadiene and 1-propanol and/or 1,2-propanediol.

    Abstract translation: 本公开提供了非天然存在的微生物，其包含：在产生乙酰辅酶A的途径中编码一种或多种酶的一种或多种多核苷酸; 在催化巴豆醇，5-羟基-3-酮戊酰基-CoA，3-酮戊-4-烯酰基-CoA或3,5-酮戊酰基-CoA转化为丁二烯的途径中编码一种或多种酶的一种或多种多核苷酸 ; 一种或多种编码一种或多种酶的多核苷酸，其在催化二羟丙基磷酸盐转化为1-丙醇和/或1,2-丙二醇的途径中，其中微生物具有降低的丙酮酸脱羧酶水平的酶活性（例如，微生物包含 破坏一种或多种脱羧酸丙酮酸酶和/或破坏一种或多种丙酮酸脱羧酸酶的一种或多种转录因子的酶），并且其中所述微生物能够生长在C6糖作为唯一碳源的厌氧 条件。 还提供了在共同生产丁二烯和1-丙醇和/或1,2-丙二醇的方法中使用所公开的非天然存在的微生物的方法。

    Modified microorganisms comprising an optimized system for oligosaccharide utilization and methods of using same
    9.
    发明授权
    Modified microorganisms comprising an optimized system for oligosaccharide utilization and methods of using same 有权

    公开(公告)号：US11345908B2

    公开(公告)日：2022-05-31

    申请号：US15327616

    申请日：2015-05-29

    Applicant: BRASKEM S.A.

    Inventor： Avram Michael Slovic ,  Daniel Johannes Koch

    IPC: C12N9/90 ,  C12N9/10 ,  C12N9/12 ,  C12P5/00 ,  C12P7/06 ,  C12P19/32

    Abstract: The present disclosure generally relates to modified microorganisms comprising an optimized system for oligosaccharide utilization comprising one or more polynucleotides coding for one or more energy independent oligosaccharide transporters for transporting an oligosaccharide into the microorganism, one or more polynucleotides coding for enzymes that catalyze the conversion of the oligosaccharide into at least one phosphorylated saccharide, and one or more polynucleotides coding for enzymes that catalyze the conversion of the phosphorylated saccharide into an isomer of the phosphorylated saccharide that is utilized in one or more enzymatic pathways in the microorganism for the production of an organic molecule such as acetic acid, acrylic acid, 3-hydroxypropionic acid, lactic acid, etc. The present disclosure also generally relates to methods of using the optimized system for oligosaccharide utilization.

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