Patent search ap:("BRISTOL-MYERS SQUIBB COMPANY") AND inv:"Jason J. Zhu" Page 1

1.

发明授权
Process for the preparation of a cyclic dinucleotide 有权

公开(公告)号：US12269840B2

公开(公告)日：2025-04-08

申请号：US17299087

申请日：2019-12-03

Applicant: Bristol-Myers Squibb Company

Inventor： Michael Anthony Schmidt , Bin Zheng , Benjamin M. Cohen , Amanda J. Rogers , Changxia Yuan , Jason J. Zhu , Chao Hang , Daniel S. Treitler , Adam Joseph Freitag , Geoffrey Eugene Purdum , Miao Yu , Melda Sezen Edmonds , Siwei Guo

IPC: C07H21/00 , C07H1/00 , C07H19/16 , C07H19/20

Abstract: The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.

2.

发明申请
SYNTHETIC PROCESSES FOR THE PRODUCTION OF 1-((3S,4R)-4-(2,6-DIFLUORO-4-METHOXYPHENYL)-2-OXOPYRROLIDIN-3-YL)-3-PHENYLUREA 有权

公开(公告)号：US20210395200A1

公开(公告)日：2021-12-23

申请号：US17292123

申请日：2019-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz , Alina Borovika , Sergei Kolotuchin , Michael R. Luzung , Jeffrey A. Nye , Yichen Tan , Serge Zaretsky , Jason J. Zhu , Martin D. Eastgate

IPC: C07D207/273

Abstract: Highly efficient processes are provided for preparing key intermediates in the synthesis of compounds (I). The process are broadly applicable and can provide selected components having a variety of substituents. Some intermediates are claimed.

3.

发明授权
Synthesis of 1,2,5-tri-o-benzoyl-3-dibenzylamino-3-deoxyribose as intermediate for producing 3′-amino-3′-deoxyadenosine and 3′-amino-3′-deoxyguanosine and the protected derivatives thereof 有权

公开(公告)号：US12060384B2

公开(公告)日：2024-08-13

申请号：US17428548

申请日：2020-02-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Changxia Yuan , Michael Anthony Schmidt , Adrian Ortiz , Amanda J. Rogers , Jason J. Zhu , Zhongmin Xu , Miao Yu , Eric M. Simmons , Shulin Wu

IPC: C07H19/167 , C07H5/06

CPC classification number: C07H19/167 , C07H5/06

Abstract: The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.

4.

发明授权
Process and intermediates for making tubulysin analogs 有权

公开(公告)号：US10106560B2

公开(公告)日：2018-10-23

申请号：US15623570

申请日：2017-06-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz , Carlos A. Guerrero , Bin Zheng , Jason J. Zhu , Michael Anthony Schmidt , Michael R. Luzung , Martin D. Eastgate

IPC: C07D417/12 , C07F7/18 , C07D211/28 , C07F7/08

Abstract: An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.

5.

发明公开
SYNTHESIS OF 1,2,5-TRI-O-BENZOYL-3-DIBENZYLAMINO-3-DEOXYRIBOSE AS INTERMEDIATE FOR PRODUCING 3'-AMINO-3'-DEOXYADENOSINE AND 3'-AMINO-3'-DEOXYGUANOSINE AND THE PROTECTED DERIVATIVES THEREOF 审中-公开

公开(公告)号：US20230357306A1

公开(公告)日：2023-11-09

申请号：US17428548

申请日：2020-02-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Changxia Yuan , Michael Anthony Schmidt , Adrian Ortiz , Amanda J. Rogers , Jason J. Zhu , Zhongmin Xu , Miao Yu , Eric M. Simmons , Shulin Wu

IPC: C07H19/167 , C07H5/06

CPC classification number: C07H19/167 , C07H5/06

Abstract: The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.

6.

发明授权
Synthetic process 有权

公开(公告)号：US11332442B2

公开(公告)日：2022-05-17

申请号：US16991357

申请日：2020-08-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： William P. Gallagher , John Ryan Coombs , Carlos A. Guerrero , David Marcoux , Qing Shi , Candice Lee Joe , Sanjeewa Rupasinghe , Jason J. Zhu , Srinivas Kalidindi , Sathasivam Shunmugaraj , Moorthy Kandasamy , Siva Sankar Bondigela , Rajappa Vaidyanathan , Shankar Tulsidas Tendulkar , Sankar Kuppusamy , Francisco González-Bobes

IPC: C07D209/60 , C07C315/04 , C07C303/40 , C07C311/03 , C07C317/24

Abstract: The invention generally relates to a process for preparing compounds, including Compound of Formula (I), useful as key intermediates in the preparation of compounds having RORγt antagonist properties.

7.

发明申请
PROCESS FOR THE PREPARATION OF A CYCLIC DINUCLEOTIDE 有权

公开(公告)号：US20220064205A1

公开(公告)日：2022-03-03

申请号：US17299087

申请日：2019-12-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael Anthony Schmidt , Bin Zheng Kendall Park , Benjamin M. Cohen , Amanda J. Rogers , Changxia Yuan Warren , Jason J. Zhu , Chao Hang , Daniel S. Treitler , Adam Josep Freitag , Geoffrey Eugene Purdum , Miao Yu , Melda Sezen Edmonds , Siwei Guo

IPC: C07H21/00 , C07H1/00 , C07H19/16 , C07H19/20

Abstract: The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.

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