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公开(公告)号：US20200223883A1
公开(公告)日：2020-07-16
申请号：US16641679
申请日：2018-08-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lan-Ying Qin , Zheming Ruan , Libing Chen , Scott Hunter Watterson , Brian E. Fink
IPC: C07H21/04 , A61K31/7084
Abstract: The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09273057B2
公开(公告)日：2016-03-01
申请号：US14414152
申请日：2013-07-12
Applicant: Bristol-Myers Squibb Company
Inventor： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer Inghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC: C07D487/04 , C07D487/08 , C07D487/10 , C07D471/10 , C07D498/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61P19/02 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07F9/6521 , C07D519/00 , C07F9/6561 , C07F7/18
CPC classification number: C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US20160022619A1
公开(公告)日：2016-01-28
申请号：US14776035
申请日：2014-03-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Audris Huang , Bin Chen , Libing Chen , Steven P. Seitz , Amy C. Hart , Jay A. Markwalder
IPC: A61K31/196 , A61K31/505 , A61K31/44 , A61K31/41 , A61K31/4245 , A61K31/42 , A61K31/36 , A61K31/27 , A61K31/216 , A61K31/18 , C07D239/42 , C07D241/42 , C07D213/84 , C07D213/75 , C07D271/12 , C07D261/14 , C07D257/04 , C07D317/66 , C07C271/28 , C07C69/743 , C07C275/42 , C07C311/47 , A61K45/06 , C07C233/55 , A61N5/10 , A61K31/498
CPC classification number: A61K31/196 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C69/743 , C07C233/55 , C07C235/38 , C07C255/44 , C07C255/57 , C07C271/28 , C07C275/42 , C07C311/47 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/02 , C07C2602/08 , C07C2602/14 , C07C2602/42 , C07D213/56 , C07D213/75 , C07D213/84 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07D261/14 , C07D271/12 , C07D317/66 , Y02A50/411 , Y02A50/414
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法，其利用 发明。
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公开(公告)号：US20200079815A1
公开(公告)日：2020-03-12
申请号：US16683667
申请日：2019-11-14
Applicant: Bristol-Myers Squibb Company
Inventor： Brian E. FINK , Dharmpal S. Dodd , Steven J. Walker , Libing Chen , Yufen Zhao , Zheming Ruan , Lan-Ying Qin , Peter Kinam Park , Muthoni G, Kamau , Lalgudi S. Harikrishnan
IPC: C07H19/213 , A61P35/00 , C07H21/02 , C07H21/00
Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20190248828A1
公开(公告)日：2019-08-15
申请号：US16272172
申请日：2019-02-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Dharmpal S. Dodd , Steven J. Walker , Libing Chen , Yufen Zhao , Zheming Ruan , Lan-Ying Qin , Peter Kinam Park , Muthoni G. Kamau , Lalgudi S. Harikrishnan
IPC: C07H19/213 , A61P35/00
Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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Patent Agency Ranking
公开(公告)号：US09675571B2
公开(公告)日：2017-06-13
申请号：US14776035
申请日：2014-03-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Audris Huang , Bin Chen , Libing Chen , Steven P. Seitz , Amy C. Hart , Jay A. Markwalder
IPC: A61K31/135 , A61K31/196 , C07C255/44 , C07C255/57 , C07D213/84 , C07C275/42 , C07D317/66 , C07C311/51 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07C233/55 , C07D261/14 , C07C235/38 , C07D271/12 , C07D213/56 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07C69/743 , C07C271/28 , C07C311/47 , C07D213/75
CPC classification number: A61K31/196 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/36 , A61K31/41 , A61K31/42 , A61K31/4245 , A61K31/44 , A61K31/498 , A61K31/505 , A61K45/06 , A61N5/10 , C07B2200/07 , C07C69/743 , C07C233/55 , C07C235/38 , C07C255/44 , C07C255/57 , C07C271/28 , C07C275/42 , C07C311/47 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/02 , C07C2602/08 , C07C2602/14 , C07C2602/42 , C07D213/56 , C07D213/75 , C07D213/84 , C07D239/42 , C07D241/42 , C07D257/04 , C07D261/08 , C07D261/14 , C07D271/12 , C07D317/66 , Y02A50/411 , Y02A50/414
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US11427610B2
公开(公告)日：2022-08-30
申请号：US16849091
申请日：2018-10-16
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Yufen Zhao , Libing Chen , Audris Huang
Abstract: The present invention is directed to compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10519187B2
公开(公告)日：2019-12-31
申请号：US16272172
申请日：2019-02-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Dharmpal S. Dodd , Steven J. Walker , Libing Chen , Yufen Zhao , Zheming Ruan , Lan-Ying Qin , Peter Kinam Park , Muthoni G. Kamau , Lalgudi S. Harikrishnan
IPC: C07H19/213 , A61P35/00 , C07K16/28
Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20160108050A1
公开(公告)日：2016-04-21
申请号：US14976476
申请日：2015-12-21
Applicant: Bristol-Myers Squibb Company
Inventor： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer lnghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC: C07D487/04 , C07F9/6561 , C07F7/18 , C07D519/00
CPC classification number: C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US10947263B2
公开(公告)日：2021-03-16
申请号：US16641679
申请日：2018-08-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lan-Ying Qin , Zheming Ruan , Libing Chen , Scott Hunter Watterson , Brian E. Fink
IPC: C07H21/04
Abstract: The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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