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    METHODS OF EVALUATING CELL CULTURE ADDITIVES
    2.
    发明申请
    METHODS OF EVALUATING CELL CULTURE ADDITIVES 审中-公开
    评价细胞培养物添加剂的方法

    公开(公告)号：US20160131634A1

    公开(公告)日：2016-05-12

    申请号：US14892723

    申请日：2014-05-29

    Applicant: BIOGEN MA INC.

    Inventor： Weiwei Hu ,  Haofan Peng ,  Erik Hughes ,  Kelly Wiltberger ,  Maureen Lanan ,  Amr Ali

    IPC: G01N33/483

    CPC classification number: G01N33/4833 ,  A61K47/10 ,  C12M27/02 ,  C12M41/32

    Abstract: The present disclosure shows, unexpectedly, that variations in cell culture performance in large-scale cell culture systems such as, for example, those used in commercial manufacturing processes, in some instances, can be attributed to often subtle variations among shear-protectant additives used during cell culture. Assessing the quality of shear-protective additives using such large-scale systems, however, is inaccurate, time-consuming and costly. To solve the problem identified, the present disclosure provides methods and compositions for evaluating the suitability of shear-protectant additives without resorting to large scale cell growth and/or protein production tests.

    Abstract translation: 本公开意外地显示，在一些情况下，大规模细胞培养系统（例如在商业制造过程中使用的那些）中的细胞培养性能的变化可以归因于所使用的剪切保护剂添加剂之间经常微妙的变化 在细胞培养过程中。 然而，使用这种大规模系统评估剪切保护添加剂的质量是不准确的，耗时且昂贵的。 为了解决所确定的问题，本公开提供了用于评估剪切保护剂添加剂的适用性而不诉诸大规模细胞生长和/或蛋白质生产测试的方法和组合物。

    GAS DELIVERY DEVICES AND ASSOCIATED SYSTEMS AND METHODS
    4.
    发明申请
    GAS DELIVERY DEVICES AND ASSOCIATED SYSTEMS AND METHODS 有权

    公开(公告)号：US20170081623A1

    公开(公告)日：2017-03-23

    申请号：US15126332

    申请日：2015-03-17

    Applicant: BIOGEN MA INC. ,  North Carolina State University

    Inventor： Fanxing Li ,  Weiwei Hu ,  Yang Liu ,  Kelly Wiltberger ,  Haofan Peng ,  Rachel Ferguson

    IPC: C12M1/107 ,  B01F3/04

    CPC classification number: C12M21/04 ,  B01F3/04248 ,  B01F3/04262 ,  B01F2003/04319 ,  B01F2003/04354 ,  B01F2215/0073 ,  B01F2215/0431 ,  B01F2215/0481

    Abstract: Systems, devices, and methods for the delivery of gas bubbles to liquids are generally described. The devices can include a primary conduit (102) comprising a plurality of openings (104) fluidically connecting an internal flow pathway (106) of the primary conduit to an environment outside the primary conduit. The devices may also include, in some instances, a secondary conduit (114) located at least partially within the primary conduit, the secondary conduit configured to redistribute the pressure of the gas delivered to the openings of the primary conduit, and comprising a plurality of openings (116) fluidically connecting an internal flow pathway (118) of the secondary conduit to a portion of the internal flow pathway (106) of the primary conduit outside the secondary conduit. Certain of the gas delivery systems and methods described herein are capable of delivering gas at relatively uniform linear flow velocities across multiple gas outlet openings. Certain embodiments are related to inventive configurations (e.g., spacings and/or sizing) of gas outlet openings in one or more conduits of the gas delivery device (e.g., the primary conduit and/or, when present, the secondary conduit). In addition, some embodiments are related to inventive arrangements for joining a gas delivery device is to a vessel, which may be part of for example, a reactor such as a bioreactor. Certain embodiments are related to the orientation of the gas delivery device and/or its components (e.g., during operation).

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