摘要:
This invention relates to novel compounds having the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要:
This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要:
This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要:
Compounds which possess Eg5 inhibitory activity and are useful for their anti-cell-proliferation (such as anti-cancer) activity and thus in methods of treatment of the human or animal body are described.
摘要:
A measuring system comprises a timing unit and at least two signal generators. The signal generators are each configured to generate a measuring signal and to supply it to a device under test. The timing unit is configured to generate start time signals, which each indicate an allowed start time of the measuring signals. Said signal generators are configured to only start generating the measuring signals at least instances of start time signals.
摘要:
A drill bit jig includes an elongate member, two jig securing elements and a rotatable drill bit guide. The elongate member is hollow so that one or more elongate drill bits may be stored therein. The drill bit guide includes a plurality of through holes where the axes of the through holes are parallel to the axis of the elongate member. Each of the plurality of through holes in the drill bit guide has a different diameter for accommodating drill bits of different thicknesses. The jig securing elements each include an L-shaped bolt and a door protecting material encasing one of the straight sections of the bolt.
摘要:
A system for monitoring and managing the energy consumption of designated devices or services obtains the point-of-use energy consumption of the designated devices or services and collects this consumption information in various formats as data. The collected data may be analyzed for peak load analysis and load shedding recommendations, among other analysis. The data may be displayed on a user interface to an energy consumer in various formats that permit the consumer to make decisions and take actions based on the displayed data or the analysis. The data may be displayed in real-time format so that the consumer may observe the instant energy consumption of a particular device. The consumer may also view a device's energy consumption to-date over a predetermined period of time. The consumer may also take an action through the system to reduce the consumer's overall energy consumption.
摘要:
A latch includes a first locking bolt, where a first extended position of the first locking bolt defines a first locked condition and a first retracted position defines a first unlocked condition. The latch also includes a second locking bolt, where a second extended position of the second locking bolt defines a second locked condition and a second retracted position defines a second unlocked condition. A biasing member operatively connects to the first locking bolt to bias the first locking bolt in the first extended position. A lever pivotally connects to the housing and operatively connects to the first locking bolt such that movement of the lever from a closed position to an opened position causes at least the first locking bolt to move from the first extended position to the first retracted position. A locking indicator is provided in associated with the second locking bolt.
摘要:
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).
摘要:
A coring tool for coring doors is provided. The coring tool may include a tool body having a first end and an opposing second end and a clamp member coupled to the tool body adjacent the second end. The tool body and the clamp member are moveable toward and away from each other in response to operation of a clamp actuator. The coring tool may also include a head having guide bushings for inserting a bit through the guide bushings for coring a door. The head may be coupled adjacent the first end of the tool body and the head may be movable toward and away from the tool body to align the guide bushing with the door to be cored.