-
公开(公告)号:US08378134B2
公开(公告)日:2013-02-19
申请号:US12570705
申请日:2009-09-30
申请人: Brian James Grimmond , Michael Todd Luttrell , Jeannette Christine DePuy , Mary Elizabeth Spilker , Michael James Rishel
发明人: Brian James Grimmond , Michael Todd Luttrell , Jeannette Christine DePuy , Mary Elizabeth Spilker , Michael James Rishel
IPC分类号: C07F15/00 , C07D225/00
CPC分类号: A61K49/103 , C07C229/16 , C07C229/76
摘要: In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I wherein R1 is independently at each occurrence a hydroxy group, a C1-C3hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3hydroxyalkyl group; and wherein Q is a charge balancing counterion. Also provided is a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement I.
摘要翻译: 一方面,本发明提供一种对比度增强剂,其包含具有结构I的铁螯合物,其中R1在每次出现时独立地为羟基,C1-C3羟烷基或C1-C3烷基,b为0-4 ; R2-R7各自独立地为氢,C1-C3羟基烷基或C1-C3烷基,条件是R1-R7中的至少一个为羟基或C1-C3羟烷基; 并且其中Q是电荷平衡抗衡离子。 还提供了具有结构IX的金属螯合配体和包含对比度增强I的医学制剂。
-
公开(公告)号:US20110076237A1
公开(公告)日:2011-03-31
申请号:US12570705
申请日:2009-09-30
申请人: Brian James Grimmond , Michael Todd Luttrell , Jeannette Christine DePuy , Mary Elizabeth Spilker , Michael James Rishel
发明人: Brian James Grimmond , Michael Todd Luttrell , Jeannette Christine DePuy , Mary Elizabeth Spilker , Michael James Rishel
IPC分类号: A61K49/10 , C07F15/02 , C07C229/02 , C07C229/36
CPC分类号: A61K49/103 , C07C229/16 , C07C229/76
摘要: In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I wherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is a charge balancing counterion. Also provided is a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement I.
摘要翻译: 一方面,本发明提供了一种对比度增强剂,其包含具有结构I的铁螯合物,其中R1在每次出现时独立地为羟基,C1-C3羟烷基或C1-C3烷基,b为0- 4; R2-R7各自独立地为氢,C1-C3羟基烷基或C1-C3烷基,条件是R1-R7中的至少一个为羟基或C1-C3羟烷基; 并且其中Q是电荷平衡抗衡离子。 还提供了具有结构IX的金属螯合配体和包含对比度增强I的医学制剂。
-
公开(公告)号:US20110077417A1
公开(公告)日:2011-03-31
申请号:US12614729
申请日:2009-11-09
IPC分类号: C07D319/08 , C07F15/02 , C07C69/003
CPC分类号: C07F7/1896 , C07D319/08 , C07F7/1804 , Y02P20/55
摘要: In one aspect, the present invention provides a protected ligand precursor having structure XXI wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence acid sensitive protecting groups.
摘要翻译: 一方面,本发明提供了具有结构XXI的受保护配体前体,其中R8在每次出现时独立地为保护的羟基,被保护的C 1 -C 3羟烷基或C 1 -C 3烷基,b为0-4; R 9 -R 11在每次出现时独立地为氢,被保护的C 1 -C 3羟基烷基或C 1 -C 3烷基,条件是R 8 -R 11中的至少一个为被保护的羟基或被保护的C 1 -C 3羟烷基 ; R12和R13各自独立地存在酸敏感的保护基。
-
公开(公告)号:US20110077396A1
公开(公告)日:2011-03-31
申请号:US12785110
申请日:2010-05-21
IPC分类号: C07F15/02 , C07D319/08 , C07C229/36 , C07F7/18 , C07C215/20
CPC分类号: A61K49/103
摘要: In one aspect, the present invention provides a protected ligand precursor having structure XX wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence a protecting group is selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, and C2-C30 aromatic radicals.
摘要翻译: 一方面,本发明提供具有结构XX的保护配体前体,其中R8在每次出现时独立地为保护的羟基,受保护的C1-C3羟烷基或C1-C3烷基,b为0-4; R 9 -R 11在每次出现时独立地为氢,被保护的C 1 -C 3羟基烷基或C 1 -C 3烷基,条件是R 8 -R 11中的至少一个为被保护的羟基或被保护的C 1 -C 3羟烷基 ; 并且R 12和R 13在每次出现时独立地为保护基团,选自C 1 -C 30脂族基,C 3 -C 30环脂族基和C 2 -C 30芳族基。
-
5.
公开(公告)号:US09251937B2
公开(公告)日:2016-02-02
申请号:US13538493
申请日:2012-06-29
申请人: Brian Christopher Bales , Brian James Grimmond , Daniel Eugene Meyer , Bruce Allan Hay , Michael Todd Luttrell
发明人: Brian Christopher Bales , Brian James Grimmond , Daniel Eugene Meyer , Bruce Allan Hay , Michael Todd Luttrell
CPC分类号: H01F1/0054 , A61K49/1842 , A61K49/186 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00
摘要: A method of sterilizing a nanoparticle preparation at a high temperature is provided. A plurality of nanoparticles are purified to form the preparation, wherein the nanoparticles comprise at least a core and a shell and the shell comprises one or more ligand species attached to the core. The nanoparticle preparation is made by a purified nanoparticle composition, a carrier fluid and an excess of the one or more ligand species not attached to the core. The ligand species attached to the core and the excess ligand species added after purification are structurally identical. The nanoparticle preparation provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.
摘要翻译: 提供了一种在高温下对纳米颗粒制剂进行灭菌的方法。 纯化多个纳米颗粒以形成制剂,其中所述纳米颗粒至少包含核和壳,并且所述壳包含连接到核的一种或多种配体物质。 纳米颗粒制备由纯化的纳米颗粒组合物,载体流体和过量的未连接到核的一种或多种配体物质制备。 在核心附着的配体物质和纯化后加入的过量配体物质在结构上是相同的。 本发明提供的纳米颗粒制剂可用作医学成像技术如X射线和磁共振成像中的造影剂。
-
6.
公开(公告)号:US20140003997A1
公开(公告)日:2014-01-02
申请号:US13538493
申请日:2012-06-29
申请人: Brian Christopher Bales , Brian James Grimmond , Daniel Eugene Meyer , Bruce Allan Hay , Michael Todd Luttrell
发明人: Brian Christopher Bales , Brian James Grimmond , Daniel Eugene Meyer , Bruce Allan Hay , Michael Todd Luttrell
CPC分类号: H01F1/0054 , A61K49/1842 , A61K49/186 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00
摘要: A method of sterilizing a nanoparticle preparation at a high temperature is provided. A plurality of nanoparticles are purified to form the preparation, wherein the nanoparticles comprise at least a core and a shell and the shell comprises one or more ligand species attached to the core. The nanoparticle preparation is made by a purified nanoparticle composition, a carrier fluid and an excess of the one or more ligand species not attached to the core. The ligand species attached to the core and the excess ligand species added after purification are structurally identical. The nanoparticle preparation provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.
摘要翻译: 提供了一种在高温下对纳米颗粒制剂进行灭菌的方法。 纯化多个纳米颗粒以形成制剂,其中所述纳米颗粒至少包含核和壳,并且所述壳包含连接到核的一种或多种配体物质。 纳米颗粒制备由纯化的纳米颗粒组合物,载体流体和过量的未连接到核的一种或多种配体物质制备。 在核心附着的配体物质和纯化后加入的过量配体物质在结构上是相同的。 本发明提供的纳米颗粒制剂可用作医学成像技术如X射线和磁共振成像中的造影剂。
-
7.
公开(公告)号:US08420747B2
公开(公告)日:2013-04-16
申请号:US12600079
申请日:2008-07-17
申请人: Jon M Malinoski , Paul D Sybert , Christopher Michael Eastman , Sumeet Jain , Rainer Koeniger , Michael Todd Luttrell , Glen David Merfeld , James Edward Pickett , Jason Joseph Testa
发明人: Jon M Malinoski , Paul D Sybert , Christopher Michael Eastman , Sumeet Jain , Rainer Koeniger , Michael Todd Luttrell , Glen David Merfeld , James Edward Pickett , Jason Joseph Testa
IPC分类号: C08F283/00 , C08F283/02 , C08K5/34 , C08K5/3435 , C08K5/3492 , B05D3/02 , B05D1/22 , B05D7/24
CPC分类号: C08G18/44 , C08G64/0208 , C08G2150/20 , C09D169/00
摘要: A thermosetting polymer material capable of being used in powder coatings. The thermosetting polymer material includes at least one hydroxyl functional aliphatic polycarbonates that is formulated and crosslinked with isocyanates to yield a thermoset organic coating material. These materials provide improved weatherability as compared to prior art powder coating materials while also being less expensive than prior art materials utilizing fluorinated polymers.
摘要翻译: 一种能够用于粉末涂料的热固性聚合物材料。 热固性聚合物材料包括至少一种羟基官能的脂族聚碳酸酯,其与异氰酸酯配制和交联以产生热固性有机涂层材料。 与现有技术的粉末涂料相比,这些材料提供了改善的耐候性,同时也比使用氟化聚合物的现有技术材料便宜。
-
公开(公告)号:US08616380B2
公开(公告)日:2013-12-31
申请号:US13527640
申请日:2012-06-20
申请人: Hua Wang , David Allen Olson , Jiang Ji , Michael Todd Luttrell , Gary William Yeager , Joseph Anthony Suriano , Lawrence Charles Costa
发明人: Hua Wang , David Allen Olson , Jiang Ji , Michael Todd Luttrell , Gary William Yeager , Joseph Anthony Suriano , Lawrence Charles Costa
CPC分类号: C02F1/441 , C02F2101/108 , C02F2103/08 , Y02A20/131
摘要: Improved methods for reducing boron concentration in seawater or brackish water, while simultaneously maintaining or improving the salt rejection of membrane and flow performance of polyamide reverse osmosis (RO) membranes include contacting the water with a composite membrane comprising moieties derived from an aromatic sulfonyl halide, a heteroaromatic sulfonyl halide, a sulfinyl halide; a sulfenyl halide; a sulfuryl halide; a phosphoryl halide; a phosphonyl halide; a phosphinyl halide; a thiophosphoryl halide; a thiophosphonyl halide, an isocyanate, a urea, a cyanate, an aromatic carbonyl halide, an epoxide or a mixture thereof.
摘要翻译: 改进的用于减少海水或微咸水中的硼浓度的方法,同时维持或改进膜的盐排斥和聚酰胺反渗透(RO)膜的流动性能包括使水与复合膜接触,所述复合膜包含衍生自芳族磺酰卤的部分, 杂芳族磺酰卤,亚硫酰卤; 硫基卤化物; 硫酰卤; 磷酰卤; 膦酰卤; 卤化膦 硫代磷酰卤; 硫代膦酰卤,异氰酸酯,脲,氰酸酯,芳族羰基卤化物,环氧化物或其混合物。
-
公开(公告)号:US20120255909A1
公开(公告)日:2012-10-11
申请号:US13527640
申请日:2012-06-20
申请人: Hua Wang , David Allen Olson , Jiang Ji , Michael Todd Luttrell , Gary William Yeager , Joseph Anthony Suriano , Lawrence Charles Costa
发明人: Hua Wang , David Allen Olson , Jiang Ji , Michael Todd Luttrell , Gary William Yeager , Joseph Anthony Suriano , Lawrence Charles Costa
IPC分类号: C02F1/44 , B01D71/56 , C02F101/10
CPC分类号: C02F1/441 , C02F2101/108 , C02F2103/08 , Y02A20/131
摘要: Improved methods for reducing boron concentration in seawater or brackish water, while simultaneously maintaining or improving the salt rejection of membrane and flow performance of polyamide reverse osmosis (RO) membranes include contacting the water with a composite membrane comprising moieties derived from an aromatic sulfonyl halide, a heteroaromatic sulfonyl halide, a sulfinyl halide; a sulfenyl halide; a sulfuryl halide; a phosphoryl halide; a phosphonyl halide; a phosphinyl halide; a thiophosphoryl halide; a thiophosphonyl halide, an isocyanate, a urea, a cyanate, an aromatic carbonyl halide, an epoxide or a mixture thereof.
摘要翻译: 改进的用于减少海水或微咸水中的硼浓度的方法,同时维持或改进膜的盐排斥和聚酰胺反渗透(RO)膜的流动性能包括使水与复合膜接触,所述复合膜包含衍生自芳族磺酰卤的部分, 杂芳族磺酰卤,亚硫酰卤; 硫基卤化物; 硫酰卤; 磷酰卤; 膦酰卤; 卤化膦 硫代磷酰卤; 硫代膦酰卤,异氰酸酯,脲,氰酸酯,芳族羰基卤化物,环氧化物或其混合物。
-
公开(公告)号:US20120156141A1
公开(公告)日:2012-06-21
申请号:US12968577
申请日:2010-12-15
CPC分类号: A61K49/1842 , A61K49/1845 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00
摘要: A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.
摘要翻译: 提供纳米颗粒组合物,其中所述组合物包含纳米颗粒金属氧化物; 和包含至少两个磷酸酯基团的磷酸化多元醇。 多元醇包含一个或多个选自聚乙烯醚部分,聚丙烯醚部分,聚丁烯醚部分以及前述亲水部分中两个或更多个的组合的亲水基团。 还提供了制备纳米颗粒组合物的方法。 本发明提供的纳米颗粒组合物可用作医学成像技术如X射线和磁共振成像中的造影剂。
-
-
-
-
-
-
-
-
-