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公开(公告)号：US11576604B2
公开(公告)日：2023-02-14
申请号：US16870134
申请日：2020-05-08
IPC分类号： A61B5/00 , A61N1/362 , A61B5/02 , A61B5/316 , A61B5/11 , A61B5/318 , A61B5/349 , A61N1/368 , A61B5/283 , A61B5/287
摘要： Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.
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公开(公告)号：US09883813B2
公开(公告)日：2018-02-06
申请号：US15240725
申请日：2016-08-18
发明人： Qingguo Zeng , Rémi DuBois , Ping Jia , Ryan Bokan , Venkatesh Vasudevan , Charulatha Ramanathan , Maria Strom , Brian P. George
IPC分类号： A61B5/044 , A61B5/04 , A61B5/00 , A61B5/0452 , A61N1/36 , A61B5/046 , A61B5/0464 , A61B18/14 , A61B5/0408 , A61B5/042
CPC分类号： A61B5/04012 , A61B5/0044 , A61B5/04085 , A61B5/0422 , A61B5/044 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/486 , A61B5/7264 , A61B18/1492 , A61B2576/023 , A61N1/36
摘要： A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface.
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公开(公告)号：US09820666B2
公开(公告)日：2017-11-21
申请号：US14614219
申请日：2015-02-04
发明人： Ryan Bokan , Charulatha Ramanathan , Ping Jia , Maria Strom , Qingguo Zeng
IPC分类号： A61B5/044 , A61B5/00 , A61B5/0402 , A61B5/06 , A61B5/042
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/0245 , A61B5/04012 , A61B5/0402 , A61B5/042 , A61B5/044 , A61B5/06 , A61B5/066 , A61B5/4836 , A61B5/7264 , A61B5/743
摘要： A method can include analyzing non-invasive electrical data for a region of interest (ROI) of a patient's anatomical structure to identify one or more zones within the ROI that contain at least one mechanism of distinct arrhythmogenic electrical activity. The method also includes analyzing invasive electrical data for a plurality of signals of interest at different spatial sites within each of the identified zones to determine intracardiac signal characteristics for the plurality of sites within each respective zone. The method also includes generating an output that integrates the at least one mechanism of distinct arrhythmogenic electrical activity for the one or more zones with intracardiac signal characteristics for the plurality of sites within each respective zone.
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公开(公告)号：US10194982B2
公开(公告)日：2019-02-05
申请号：US15226448
申请日：2016-08-02
发明人： Rémi Dubois , Brian P. George , Charulatha Ramanathan , Qingguo Zeng , Maria Strom , Venkatesh Vasudevan , Ryan Bokan , Ping Jia
IPC分类号： A61B18/14 , A61B5/044 , A61B5/04 , A61B5/00 , A61B5/046 , A61B5/0464 , A61B5/0408 , A61B17/00 , A61B18/00
摘要： A non-transitory computer-readable medium can have instructions executable by a processor. The instructions can include an electrogram reconstruction method to generate reconstructed electrogram signals for each of a multitude of points residing on or near a predetermined cardiac envelope based on geometry data and non-invasively measured body surface electrical signals. The instructions can include a phase calculator to compute phase signals for the multitude of points based on the reconstructed electrogram signals and a visualization engine to generate an output based on the computed phase signals.
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公开(公告)号：US10004413B2
公开(公告)日：2018-06-26
申请号：US15269396
申请日：2016-09-19
发明人： Ryan Bokan , Charulatha Ramanathan , Ping Jia , Maria Strom
IPC分类号： A61B5/00 , A61B5/04 , A61B5/042 , A61B5/0432 , A61B5/044 , A61B5/0452 , A61B18/06 , A61N1/362 , A61B18/00
CPC分类号： A61B5/04012 , A61B5/0422 , A61B5/0432 , A61B5/044 , A61B5/0452 , A61B5/4839 , A61B5/4848 , A61B5/6858 , A61B5/742 , A61B5/748 , A61B18/06 , A61B2018/00577 , A61N1/362
摘要： A method includes storing baseline data representing at least one local or global electrical characteristics for at least a portion of a region of interest (ROI) of a patient's anatomical structure. The baseline data is determined based on electrical measurement data obtained during at least one first measurement interval. The method also includes storing in memory other data representing the at least one local or global electrical characteristics for the at least a portion of the ROI based on electrical measurement data obtained during at least one subsequent measurement interval. The method also includes evaluating the baseline data relative to the other data to determine a change in the at least one local or global electrical characteristics. The method also includes generating an output based on the evaluating to provide an indication of progress or success associated with the applying the treatment.
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公开(公告)号：US09977060B2
公开(公告)日：2018-05-22
申请号：US15269488
申请日：2016-09-19
发明人： Brian P. George , Charulatha Ramanathan , Ping Jia , Qingguo Zeng , Venkatesh Vasudevan , Maria Strom , Ryan Bokan , Rémi Dubois
IPC分类号： G06F19/00 , G01R25/00 , A61B5/00 , A61B5/0402 , A61B5/0408 , A61B5/0428 , A61B5/0452 , A61B6/00 , A61B8/08 , A61B5/0476 , A61B5/0488 , A61B5/0496
CPC分类号： G01R25/00 , A61B5/0035 , A61B5/0402 , A61B5/04085 , A61B5/04288 , A61B5/04525 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/7203 , A61B5/7221 , A61B5/7246 , A61B5/7264 , A61B6/5247 , A61B8/5261
摘要： A computer-implemented method can include determining an amplitude for each of a plurality of input channels, corresponding to respective nodes. A measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. The method can also include comparing an amplitude for each node relative to other nodes to determine temporary bad channels. For each of the temporary bad channels, a measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. Channel integrity can then be identified based on the computed measures of similarity.
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公开(公告)号：US09470728B2
公开(公告)日：2016-10-18
申请号：US13890058
申请日：2013-05-08
发明人： Brian P. George , Charulatha Ramanathan , Ping Jia , Qingguo Zeng , Venkatesh Vasudevan , Maria Strom , Ryan Bokan , Remi Dubois
IPC分类号： G06F19/00 , G01R25/00 , A61B5/00 , A61B5/0402 , A61B5/0408 , A61B6/00 , A61B8/08 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0428
CPC分类号： G01R25/00 , A61B5/0035 , A61B5/0402 , A61B5/04085 , A61B5/04288 , A61B5/04525 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/7203 , A61B5/7221 , A61B5/7246 , A61B5/7264 , A61B6/5247 , A61B8/5261
摘要： A computer-implemented method can include determining an amplitude for each of a plurality of input channels, corresponding to respective nodes. A measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. The method can also include comparing an amplitude for each node relative to other nodes to determine temporary bad channels. For each of the temporary bad channels, a measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. Channel integrity can then be identified based on the computed measures of similarity.
摘要翻译： 计算机实现的方法可以包括确定对应于相应节点的多个输入通道中的每一个的幅度。 可以在每个节点的输入通道和其相邻节点的输入通道之间计算相似度。 该方法还可以包括比较每个节点相对于其他节点的振幅以确定暂时的坏信道。 对于每个临时不良通道，可以在每个节点的输入通道和其相邻节点的输入通道之间计算相似度。 然后可以基于所计算的相似度测量来识别信道完整性。
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公开(公告)号：US10682066B2
公开(公告)日：2020-06-16
申请号：US15805903
申请日：2017-11-07
IPC分类号： A61B5/0402 , A61B5/04 , A61B5/00 , A61N1/362 , A61B5/0452 , A61B5/11 , A61B5/02 , A61B5/042 , A61N1/368
摘要： Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.
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公开(公告)号：US10076260B2
公开(公告)日：2018-09-18
申请号：US15711642
申请日：2017-09-21
发明人： Ryan Bokan , Charulatha Ramanathan , Ping Jia , Maria Strom , Qingguo Zeng
IPC分类号： A61B5/0452 , A61B5/024 , A61B5/0245 , A61B5/04 , A61B5/044
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/0245 , A61B5/04012 , A61B5/0402 , A61B5/042 , A61B5/044 , A61B5/06 , A61B5/066 , A61B5/4836 , A61B5/7264 , A61B5/743
摘要： A method can include analyzing non-invasive electrical data for a region of interest (ROI) of a patient's anatomical structure to identify one or more zones within the ROI that contain at least one mechanism of distinct arrhythmogenic electrical activity. The method also includes analyzing invasive electrical data for a plurality of signals of interest at different spatial sites within each of the identified zones to determine intracardiac signal characteristics for the plurality of sites within each respective zone. The method also includes generating an output that integrates the at least one mechanism of distinct arrhythmogenic electrical activity for the one or more zones with intracardiac signal characteristics for the plurality of sites within each respective zone.
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公开(公告)号：US09750940B2
公开(公告)日：2017-09-05
申请号：US15250171
申请日：2016-08-29
发明人： Charulatha Ramanathan , Harold Wodlinger , Ping Jia , Maria Strom
IPC分类号： A61N1/368 , A61N1/365 , A61B5/04 , A61B5/0402 , G06F19/00 , A61B5/00 , A61B5/0408 , A61N1/362
CPC分类号： A61N1/36585 , A61B5/04012 , A61B5/0402 , A61B5/04085 , A61B5/4836 , A61B5/7425 , A61B2576/023 , A61N1/3625 , A61N1/3627 , A61N1/365 , A61N1/36514 , A61N1/36528 , A61N1/368 , A61N1/3684 , G06F19/00 , G06F19/3481 , G16H40/63 , G16H50/50
摘要： A method can include providing at least one parameter to control a therapy that is applied to at least one internal anatomical structure of a patient. Electrical data can be obtained from the patient, including electrical data acquired via a plurality of sensors during each of a plurality of iterations of the therapy. The electrical data can be analyzed for a respective value of the at least one parameter of the therapy at each of the plurality of iterations of the applied therapy to compute an indication of at least one function of the at least one internal anatomical structure of the patient at each respective iteration of the applied therapy. The computed indication can be stored in memory. At least one parameter of the therapy can be adjusted for delivery in a subsequent one of the plurality of iterations based on the indication of the at least one function.
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