公开(公告)号：US20200276176A1

公开(公告)日：2020-09-03

申请号：US16799651

申请日：2020-02-24

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Jonathan Bard ,  Matthew R. Lee ,  Longbin Liu ,  Michael Edward Prime ,  Samuel Coe

IPC: A61K31/454 ,  A61K31/427 ,  A61K31/165 ,  A61K47/54

Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.

公开(公告)号：US11992535B2

公开(公告)日：2024-05-28

申请号：US17125905

申请日：2020-12-17

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Matthew Lee ,  Celia Dominguez ,  Peter David Johnson ,  Christopher John Brown ,  Sarah Hayes ,  Adrian Kotey ,  Matthew Robert Mills ,  Michael Edward Prime

IPC: A61K51/04 ,  C07B59/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107

CPC classification number: A61K51/0455 ,  A61K51/0459 ,  A61K51/0468 ,  C07B59/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07B2200/05

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US20220409615A1

公开(公告)日：2022-12-29

申请号：US17318693

申请日：2021-05-12

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Elizabeth M. Doherty ,  Longbin Liu ,  Matthew Lee ,  Mark Stuart Chambers ,  Karine Fabienne Malagu ,  Perla Breccia ,  Alan F. Haughan ,  Huw D. Vater ,  Andrew J. Stott ,  William R. K. Esmieu ,  Stephen John Webster ,  Amanda J. Van De Poël

IPC: A61K31/497 ,  C07D471/04 ,  C07D519/00 ,  A61K31/4985 ,  C07D487/04 ,  C07D403/14 ,  A61K31/506 ,  A61K31/501 ,  C07D413/14 ,  A61P25/28

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

公开(公告)号：US20220372045A1

公开(公告)日：2022-11-24

申请号：US17729881

申请日：2022-04-26

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Jonathan Bard ,  Vinod Khetarpal ,  Ashley Jarvis ,  Sarah Hayes ,  John E. Mangette

IPC: C07D498/04 ,  A61K51/04

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US20210236663A1

公开(公告)日：2021-08-05

申请号：US17125905

申请日：2020-12-17

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Matthew Lee ,  Celia Dominguez ,  Peter David Johnson ,  Christopher John Brown ,  Sarah Hayes ,  Adrian Kotey ,  Matthew Robert Mills ,  Michael Edward Prime

IPC: A61K51/04 ,  C07D401/14 ,  C07D401/06 ,  C07D471/04 ,  C07D401/12 ,  C07D491/107 ,  C07D487/04 ,  C07D413/14 ,  C07B59/00

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US20240342317A1

公开(公告)日：2024-10-17

申请号：US18402399

申请日：2024-01-02

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Matthew Lee ,  Celia Dominguez ,  Peter David Johnson ,  Catherine Jane Greenaway ,  Kanika Khurana ,  Matthew Robert Mills ,  Filippo Rota

IPC: A61K51/04 ,  C07B59/00 ,  C07D231/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00

CPC classification number: A61K51/0459 ,  A61K51/0455 ,  A61K51/0463 ,  C07B59/002 ,  C07D231/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00 ,  C07B2200/05

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US11918662B2

公开(公告)日：2024-03-05

申请号：US17344582

申请日：2021-06-10

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Matthew Lee ,  Celia Dominguez ,  Peter David Johnson ,  Catherine Jane Greenaway ,  Kanika Khurana ,  Matthew Robert Mills ,  Filippo Rota

IPC: A61K51/04 ,  C07B59/00 ,  C07D231/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00

CPC classification number: A61K51/0459 ,  A61K51/0455 ,  A61K51/0463 ,  C07B59/002 ,  C07D231/12 ,  C07D471/04 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00 ,  C07B2200/05

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US20220409600A1

公开(公告)日：2022-12-29

申请号：US17752683

申请日：2022-05-24

Applicant: CHDI Foundation, Inc.

Inventor： Celia Dominguez ,  Jonathan Bard ,  Matthew R. Lee ,  Longbin Liu ,  Michael Edward Prime ,  Samuel Coe

IPC: A61K31/454 ,  A61K47/54 ,  A61K31/165 ,  A61K31/427

Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.

公开(公告)号：US20220339302A1

公开(公告)日：2022-10-27

申请号：US17715661

申请日：2022-04-07

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Celia Dominguez ,  Jonathan Bard ,  Christopher John Brown ,  Xuemei Chen ,  Daniel Clark-Frew ,  Matthew Robert Mills ,  Peter David Johnson ,  Elise Gadouleau

IPC: A61K51/04 ,  A61P25/28 ,  C07D401/14

Abstract: Provided herein are certain isoindolinone compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

公开(公告)号：US20210393812A1

公开(公告)日：2021-12-23

申请号：US17344582

申请日：2021-06-10

Applicant: CHDI Foundation, Inc.

Inventor： Longbin Liu ,  Matthew Lee ,  Celia Dominguez ,  Peter David Johnson ,  Catherine Jane Greenaway ,  Kanika Khurana ,  Matthew Robert Mills ,  Filippo Rota

IPC: A61K51/04 ,  C07B59/00 ,  C07D487/04 ,  C07D487/14 ,  C07D519/00 ,  C07D231/12 ,  C07D471/04

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.