公开(公告)号：US10532016B2

公开(公告)日：2020-01-14

申请号：US16213871

申请日：2018-12-07

Applicant: Colgate-Palmolive Company

Inventor： Zhigang Hao ,  Dennis Zhang ,  Donghui Wu ,  Ravi Subramanyam ,  Chi-Yuan Cheng ,  Long Pan ,  Stanislav Jaracz

IPC: A61K8/58 ,  A61Q11/00 ,  A61Q17/00 ,  A61Q15/00

Abstract: Disclosed herein are zinc-amino acid-tripolyphosphate complexes, oral care and personal care compositions comprising zinc-amino acid-tripolyphosphate complexes, and methods of making and using the same.

公开(公告)号：US10357438B2

公开(公告)日：2019-07-23

申请号：US15529635

申请日：2015-12-15

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Harsh M. Trivedi ,  Lyndsay Schaeffer-Korbylo

IPC: A61K8/27 ,  A61K8/362 ,  A61K8/365 ,  A61Q11/00

Abstract: The disclosure provides oral care compositions comprising zinc ions and citrate ions with molar ratios which unexpectedly high zinc bioavailability, together with methods of preparing and using the same.

公开(公告)号：US10335615B2

公开(公告)日：2019-07-02

申请号：US15629190

申请日：2017-06-21

Applicant: Colgate-Palmolive Company

Inventor： Ying Yang ,  Dandan Chen ,  Robert D'Ambrogio ,  Paul Thomson ,  Harsh Mahendra Trivedi ,  Michael Prencipe ,  James Masters ,  Stanislav Jaracz

IPC: A61K8/21 ,  A61K8/22 ,  A61K8/27 ,  A61K8/34 ,  A61K8/35 ,  A61K8/97 ,  A61K45/06 ,  A61K8/365 ,  A61Q11/00 ,  A61Q17/00 ,  A61K36/9068

Abstract: This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.

公开(公告)号：US10053406B2

公开(公告)日：2018-08-21

申请号：US15331640

申请日：2016-10-21

Applicant: Colgate-Palmolive Company ,  The Trustees of the University of Pennsylvania

Inventor： Stanislav Jaracz ,  Marisa Kozlowski ,  Young Eun Lee ,  Sun Min Kim

IPC: C07C37/055 ,  C07C37/14 ,  C07C41/24 ,  C07C41/09 ,  C07C41/22 ,  C07C39/21 ,  C07C37/50

CPC classification number: C07C37/0555 ,  C07C37/11 ,  C07C37/14 ,  C07C37/50 ,  C07C39/15 ,  C07C39/21 ,  C07C41/09 ,  C07C41/16 ,  C07C41/22 ,  C07C41/24 ,  C07C41/30 ,  C07C43/2055 ,  C07C43/225 ,  C07C43/215

Abstract: Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.

公开(公告)号：US20250049681A1

公开(公告)日：2025-02-13

申请号：US18808749

申请日：2024-08-19

Applicant: Colgate-Palmolive Company

Inventor： Venda Porter MALONEY ,  Vyoma Patel ,  Steven Fisher ,  André Morgan ,  Michael Prencipe ,  Stanislav Jaracz

IPC: A61K8/58 ,  A61K8/24 ,  A61K8/27 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/44 ,  A61Q11/00

Abstract: Described herein are compositions comprising combinations of metal salts, and methods of preparing and using the same.

公开(公告)号：US11517512B2

公开(公告)日：2022-12-06

申请号：US16631481

申请日：2018-07-16

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Long Pan ,  Karthik Sambanthamoorthy ,  Junhong Mao ,  Aixing Fan

IPC: A61K8/27 ,  A61K8/49 ,  A61Q17/00 ,  A61Q19/10 ,  A61K8/44 ,  A61K8/42

Abstract: Disclosed herein are personal care compositions comprising Zn:usnate complexes having a 1:2 zinc to usnate molar ratio. Methods of making and using the compositions are also provided. The personal care compositions may include a cleansing component and an antibacterial component, wherein the antibacterial component comprises Zn:usnate complexes having a 1:2 zinc to usnate molar ratio.

公开(公告)号：US09625449B2

公开(公告)日：2017-04-18

申请号：US14580485

申请日：2014-12-23

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Harsh M. Trivedi ,  Lyndsay Schaeffer-Korbylo ,  Lynette Zaidel

IPC: G01N21/78 ,  G01N33/84 ,  G01N33/50

CPC classification number: G01N33/5082 ,  G01N21/78 ,  G01N33/84

Abstract: An in vitro method for determining the bioavailability of zinc (II) ions from an oral care composition comprises: providing a sample comprising, the oral care composition; contacting the sample with a biorelevant substrate, separating the biorelevant substrate from the sample, contacting the biorelevant substrate with an indicator under conditions selected such that the indicator is capable of reacting with zinc (II) ions, and determining a light absorbance of the indicator. The indicator is zincon or a salt thereof. The method is useful for estimating the ability of an oral care composition to deliver therapeutically-active zinc (II) ions to the oral cavity. Also provided is the use of zincon and a biorelevant substrate in vitro to determine the bioavailability of zinc (II) ions from an oral care composition comprising, a zinc source.

公开(公告)号：US20170020795A1

公开(公告)日：2017-01-26

申请号：US15287242

申请日：2016-10-06

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Venda Porter Maloney ,  Vyoma Patel ,  Steven Wade Fisher ,  Andre Michelle Morgan ,  Michael Prencipe ,  Stanislav Jaracz

IPC: A61K8/58 ,  A61K8/362 ,  A61K8/24 ,  A61K8/27

CPC classification number: A61K8/58 ,  A61K8/24 ,  A61K8/27 ,  A61K8/36 ,  A61K8/361 ,  A61K8/362 ,  A61K8/365 ,  A61K8/44 ,  A61Q11/00

Abstract: Described herein are compositions comprising combinations of metal salts, and methods of preparing and using the same.

Abstract translation: 本文描述的是包含金属盐的组合的组合物，以及制备和使用它们的方法。

公开(公告)号：US09435745B2

公开(公告)日：2016-09-06

申请号：US14580510

申请日：2014-12-23

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Ravi Subramanyam ,  Michael Prencipe

IPC: G01N21/78 ,  G01N33/20 ,  G01N21/79 ,  G01N21/77 ,  A61Q11/00

CPC classification number: G01N21/78 ,  A61K8/466 ,  A61K2800/45 ,  A61Q11/00 ,  G01N21/77 ,  G01N21/79 ,  G01N33/20

Abstract: A method of measuring the relative rates of release of a target metal ion from two or more samples includes: (i) providing at least two aliquots of a solution including an indicator, the indicator having a color; (ii) dispersing a sample into each aliquot; and (iii) during step (ii), monitoring the color of the indicator in situ to determine the rates of release of the target metal ions from the samples relative to one another. Each sample includes at least one source of the target metal ion. The indicator contains zincon. The samples are oral care compositions selected from a toothpaste, a tooth gel, and a tooth powder. The target metal ion is selected from the stannous and zinc (II).

Abstract translation: 测量来自两个或更多个样品的靶金属离子的相对释放速率的方法包括：（i）提供包含指示剂的溶液的至少两个等分试样，所述指示剂具有颜色; （ii）将样品分散到每个等分试样中; 和（iii）在步骤（ii）期间，在现场监测指示剂的颜色，以确定目标金属离子从样品相对于彼此的释放速率。 每个样品包括至少一种目标金属离子源。 指标包含zincon。 样品是选自牙膏，牙胶和牙粉的口腔护理组合物。 目标金属离子选自亚锡和锌（II）。

公开(公告)号：US20160178595A1

公开(公告)日：2016-06-23

申请号：US14580497

申请日：2014-12-23

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Michael Prencipe

IPC: G01N33/20

CPC classification number: G01N33/20 ,  A61Q11/00 ,  G01N21/77 ,  G01N21/78 ,  G01N21/79

Abstract: A method of detecting stannous ions that includes providing a zincon-containing indicator having a colour, contacting the indicator with a sample, and detecting any resulting change in the colour of the indicator, wherein a change in the colour of the indicator from the colour to colourless indicates that stannous ions are present in the sample. The method is useful for the analysis of oral care compositions. Also provided is the use of zinc on as an indicator for detecting stannous ions.

Abstract translation: 一种检测亚锡离子的方法，其包括提供具有颜色的含有蕴含锌的指示剂，使所述指示剂与样品接触，并检测所述指示剂的颜色的任何变化，其中所述指示剂的颜色从所述颜色变为 无色表示样品中存在亚锡离子。 该方法对口腔护理组合物的分析是有用的。 还提供了使用锌作为检测亚锡离子的指示剂。