公开(公告)号：US11826724B2

公开(公告)日：2023-11-28

申请号：US17372985

申请日：2021-07-12

Applicant: CytoSorbents Corporation

Inventor： Tamaz Guliashvili ,  Thomas Golobish ,  Maryann Gruda ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vincent Capponi ,  Phillip Chan ,  Wei-Tai Young

IPC: A61K38/00 ,  B01J20/26 ,  B01D15/34 ,  B01J20/28 ,  B01J20/32 ,  A61K9/00 ,  A61K31/745 ,  A61M1/36 ,  B01D15/12

CPC classification number: B01J20/261 ,  A61K9/0031 ,  A61K9/0053 ,  A61K31/745 ,  A61M1/3679 ,  B01D15/34 ,  B01J20/262 ,  B01J20/267 ,  B01J20/2808 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/327 ,  B01J20/3208 ,  B01J20/3231 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3289 ,  B01D15/125

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：US11723916B2

公开(公告)日：2023-08-15

申请号：US17341912

申请日：2021-06-08

Applicant: CytoSorbents Corporation

Inventor： Thomas Golobish ,  Maryann Gruda ,  Tamaz Guliashvili ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vi Dan ,  Wei-Tai Young ,  Vincent Capponi ,  Phillip Chan

IPC: A61K31/795 ,  A61M5/165 ,  B01J20/26 ,  B01J39/20 ,  B01J20/28 ,  A61K47/20 ,  A61K47/26 ,  A61M1/36 ,  A61M5/14

CPC classification number: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M5/165 ,  B01J20/264 ,  B01J20/267 ,  B01J20/28069 ,  B01J39/20 ,  A61M1/3679 ,  A61M5/14

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

公开(公告)号：US20210401874A1

公开(公告)日：2021-12-30

申请号：US17341912

申请日：2021-06-08

Applicant: CytoSorbents Corporation

Inventor： Thomas Golobish ,  Maryann Gruda ,  Tamaz Guliashvili ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vi Dan ,  Wei-Tai Young ,  Vincent Capponi ,  Phillip Chan

IPC: A61K31/795 ,  A61M5/165 ,  B01J20/26 ,  B01J39/20 ,  B01J20/28 ,  A61K47/20 ,  A61K47/26

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

公开(公告)号：US11065600B2

公开(公告)日：2021-07-20

申请号：US16303232

申请日：2017-05-18

Applicant: CYTOSORBENTS CORPORATION

Inventor： Tamaz Guliashvili ,  Thomas Golobish ,  Maryann Gruda ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vincent Capponi ,  Phillip Chan ,  Wei-Tai Young

IPC: A61K31/745 ,  B01J20/00 ,  B01J20/26 ,  B01D15/34 ,  B01J20/28 ,  B01J20/32 ,  A61K9/00 ,  A61M1/36 ,  B01D15/12

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：US12121879B2

公开(公告)日：2024-10-22

申请号：US17298968

申请日：2019-12-02

Applicant: CytoSorbents Corporation

Inventor： Tamaz Guliashvili ,  Maryann Gruda ,  Thomas Golobish ,  David James ,  Karl-Gustav Ruggeberg ,  Pamela O'Sullivan ,  Sarah Patterson

IPC: B01J20/32 ,  B01D15/38 ,  B01J20/28 ,  C07K1/22 ,  C07K16/06

CPC classification number: B01J20/3274 ,  B01D15/3809 ,  B01J20/28019 ,  B01J20/28078 ,  B01J20/3212 ,  C07K1/22 ,  C07K16/065

Abstract: The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.

公开(公告)号：US20240082817A1

公开(公告)日：2024-03-14

申请号：US18502809

申请日：2023-11-06

Applicant: CytoSorbents Corporation

Inventor： Tamaz Guliashvili ,  Thomas Golobish ,  Maryann Gruda ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vincent Capponi ,  Phillip Chan ,  Wei-Tai Young

IPC: B01J20/26 ,  A61K9/00 ,  A61K31/745 ,  A61M1/36 ,  B01D15/34 ,  B01J20/28 ,  B01J20/32

CPC classification number: B01J20/261 ,  A61K9/0031 ,  A61K9/0053 ,  A61K31/745 ,  A61M1/3679 ,  B01D15/34 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/2808 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/3208 ,  B01J20/3231 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3289 ,  B01D15/125

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules.

公开(公告)号：US20220032267A1

公开(公告)日：2022-02-03

申请号：US17372985

申请日：2021-07-12

Applicant: CytoSorbents Corporation

Inventor： Tamaz Guliashvili ,  Thomas Golobish ,  Maryann Gruda ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vincent Capponi ,  Phillip Chan ,  Wei-Tai Young

IPC: B01J20/26 ,  B01D15/34 ,  B01J20/28 ,  B01J20/32 ,  A61K9/00 ,  A61K31/745 ,  A61M1/36

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：US11040061B2

公开(公告)日：2021-06-22

申请号：US15769361

申请日：2016-10-21

Applicant: CYTOSORBENTS CORPORATION

Inventor： Thomas Golobish ,  Maryann Gruda ,  Tamaz Guliashvili ,  Pamela O'Sullivan ,  Andrew Scheirer ,  Vi Dan ,  Wei-Tai Young ,  Vincent Capponi ,  Phillip Chan

IPC: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M5/165 ,  B01J20/26 ,  B01J39/20 ,  B01J20/28 ,  A61M1/36 ,  A61M5/14

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.