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    Sensor For Biomolecules and a Method of Analysis Using Said Sensor
    3.
    发明申请
    Sensor For Biomolecules and a Method of Analysis Using Said Sensor 审中-公开
    用于生物分子的传感器和使用所述传感器的分析方法

    公开(公告)号：US20080312105A1

    公开(公告)日：2008-12-18

    申请号：US12158076

    申请日：2006-12-15

    申请人： Johannes Bacher ,  Andreas Boos ,  Gerd Luedke

    发明人： Johannes Bacher ,  Andreas Boos ,  Gerd Luedke

    IPC分类号： C40B50/18 ,  C40B60/12

    CPC分类号： B01L3/502 ,  B01L2300/0636 ,  B01L2300/0681

    摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.

    摘要翻译： 公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种靶分子。 该方法包括将所述样品流体引入配备有多孔底物的室中的步骤，将一个或多个探针分子施加到所述多孔底物上，并且所述探针能够特异性结合所述一个或多个靶分子。 该方法还包括相对于彼此移动所述衬底和所述室的步骤，以迫使所述样品流体通过所述多孔衬底的孔并用所述一个或多个探针分子俘获所述一个或多个靶分子。 还公开了用于分析样品流体的传感器。

    Sensor for Biomolecules and a Method for Preparing and Using the Same
    4.
    发明申请
    Sensor for Biomolecules and a Method for Preparing and Using the Same 审中-公开
    生物分子传感器及其制备和使用方法

    公开(公告)号：US20080300144A1

    公开(公告)日：2008-12-04

    申请号：US12158082

    申请日：2006-12-13

    申请人： Johannes Bacher ,  Andreas Boos ,  Gerd Luedke

    发明人： Johannes Bacher ,  Andreas Boos ,  Gerd Luedke

    IPC分类号： C40B30/04 ,  C40B60/12

    CPC分类号： G01N33/54366

    摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the steps of applying a non-activated porous organic polymer membrane with probes in the form of an array of probe locations, said probes being able to specifically bind to said one or more target molecules. Furthermore, the method comprises the steps of blocking areas remaining free of probes of said porous organic polymer membrane with one or more blocking substances and forcing the sample fluid repeatedly in one or two directions through the pores of said porous organic polymer membrane. Also disclosed is a sensor for the analysis of a sample fluid.

    摘要翻译： 公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种靶分子。 该方法包括以探针位置阵列的形式施加非活化多孔有机聚合物膜的步骤，所述探针能够特异性地结合所述一个或多个靶分子。 此外，该方法包括以下步骤：用一种或多种封闭物质阻挡剩余的不含所述多孔有机聚合物膜的探针的区域，并通过所述多孔有机聚合物膜的孔在一个或两个方向上反复强制样品流体。 还公开了用于分析样品流体的传感器。

    Method of Performing a Microarray Assay
    5.
    发明申请
    Method of Performing a Microarray Assay 审中-公开
    进行微阵列测定的方法

    公开(公告)号：US20080269069A1

    公开(公告)日：2008-10-30

    申请号：US12158074

    申请日：2006-12-11

    申请人： Johannes Bacher ,  Andreas Boos ,  Gerd Luedke

    发明人： Johannes Bacher ,  Andreas Boos ,  Gerd Luedke

    IPC分类号： C40B30/10

    CPC分类号： G01N33/54386 ,  C12Q1/6837 ,  G01N33/544 ,  C12Q2565/102 ,  C12Q2537/143

    摘要： Disclosed is a method for performing a microarray assay on one or more sample fluid(s), said fluids comprising target biological compounds. The method comprises the step of tagging said target biological compounds with labels. The following step comprises contacting said sample fluid(s) with a substrate and detecting the presence of said labels at the surface of said substrate. The method is suitable for the simultaneous analysis, in one microarray, of one or more types of target biological compounds, in one or more sample fluid(s). To this end each of said types of biological compounds is tagged with a different label so that target biological compounds belonging to different sample fluids have different labels. Said different labels are discriminable upon detection at the surface of said substrate. Also disclosed is the use of a polymer substrate in a method for performing a microarray assay.

    摘要翻译： 公开了一种在一种或多种样品流体上进行微阵列测定的方法，所述流体包含靶生物化合物。 该方法包括用标记标记所述靶生物化合物的步骤。 接下来的步骤包括使所述样品流体与基底接触，并在所述基底的表面检测所述标记的存在。 该方法适用于在一个或多个样品流体中在一个微阵列中同时分析一种或多种类型的靶生物化合物。 为此，每种所述类型的生物化合物被标记有不同的标记，使得属于不同样品流体的目标生物化合物具有不同的标记。 所述不同标签在所述基板的表面检测时是可辨别的。 还公开了在进行微阵列测定的方法中使用聚合物底物。

    Charged Particle Reduction in Analyte Processing
    6.
    发明申请
    Charged Particle Reduction in Analyte Processing 审中-公开
    分析物处理中的带电粒子减少

    公开(公告)号：US20070246362A1

    公开(公告)日：2007-10-25

    申请号：US10580474

    申请日：2004-02-02

    申请人： Gerd Luedke

    发明人： Gerd Luedke

    IPC分类号： G01N27/26 ,  B01J19/00

    CPC分类号： B01L3/502753 ,  B01L3/502761 ,  B01L2300/0816 ,  B01L2400/0421 ,  G01N27/44773

    摘要： A method for processing analytes in a first solution containing charged particles, wherein the first solution is filling a compartment having reservoirs. The compartment is subjected to an electric field, so that the charged particles are mainly moved into the reservoirs, thereby reducing the amount of the charged particles in a part of the first solution, which is located in a section of the compartment. The part of the first solution obtained in A) containing the analytes is then subjected to further processing.

    摘要翻译： 一种在含有带电粒子的第一溶液中处理分析物的方法，其中第一溶液填充具有储存器的隔室。 隔室经受电场，使得带电粒子主要移入储存器中，从而减少位于隔室的一部分中的第一溶液的一部分中的带电粒子的量。 然后将含有分析物的A）中获得的第一溶液的一部分进行进一步处理。

    Nucleic Acid Detection
    7.
    发明申请
    Nucleic Acid Detection 审中-公开
    核酸检测

    公开(公告)号：US20080311668A1

    公开(公告)日：2008-12-18

    申请号：US10573438

    申请日：2003-11-17

    申请人： Gerd Luedke

    发明人： Gerd Luedke

    IPC分类号： G01N33/00

    CPC分类号： C12Q1/6816 ,  Y10T436/143333 ,  C12Q2565/125 ,  C12Q2525/179

    摘要： Disclosed is the detection of a target nucleic acid sequence in a mixture of different nucleic acids having additional binding sites, by: hybridizing the target nucleic acid sequence with a probe in liquid phase, the probe having a first label. The additional binding sites are hybridized with single stranded nucleic acids having random primary sequences in liquid phase, the different nucleic acids are separated, and the target nucleic acid is detected by using the labeled probe.

    摘要翻译： 公开了通过以下方式检测具有另外结合位点的不同核酸的混合物中的靶核酸序列：通过将目标核酸序列与液相中的探针杂交，所述探针具有第一标记。 另外的结合位点与在液相中具有随机一级序列的单链核酸杂交，分离不同的核酸，并通过使用标记的探针检测靶核酸。

    Mixing of fluids
    8.
    发明申请
    Mixing of fluids 审中-公开
    混合液体

    公开(公告)号：US20070161118A1

    公开(公告)日：2007-07-12

    申请号：US10580478

    申请日：2004-01-29

    申请人： Gerd Luedke ,  Andreas Ruefer

    发明人： Gerd Luedke ,  Andreas Ruefer

    IPC分类号： G01N1/10

    CPC分类号： B01F13/0076 ,  B01F11/0071 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  Y10T436/2575

    摘要： A method for mixing at least two fluids comprising: (a) introducing the at least two fluids into a common first conduit which includes a junction with a second conduit and transporting the fluids to the junction, (b) subjecting the fluids in the first conduit at the junction to a force in order to alternately change the direction of flow of the fluids.

    摘要翻译： 一种用于混合至少两种流体的方法，包括：（a）将所述至少两种流体引入共同的第一导管，所述公共第一导管包括与第二导管的连接并将流体输送到所述连接处，（b）使所述流体在所述第一导管 在连接处的力以便交替地改变流体的流动方向。