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    Sensor For Biomolecules and a Method of Analysis Using Said Sensor
    3.
    发明申请
    Sensor For Biomolecules and a Method of Analysis Using Said Sensor 审中-公开
    用于生物分子的传感器和使用所述传感器的分析方法

    公开(公告)号：US20080312105A1

    公开(公告)日：2008-12-18

    申请号：US12158076

    申请日：2006-12-15

    申请人： Johannes Bacher ,  Andreas Boos ,  Gerd Luedke

    发明人： Johannes Bacher ,  Andreas Boos ,  Gerd Luedke

    IPC分类号： C40B50/18 ,  C40B60/12

    CPC分类号： B01L3/502 ,  B01L2300/0636 ,  B01L2300/0681

    摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.

    摘要翻译： 公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种靶分子。 该方法包括将所述样品流体引入配备有多孔底物的室中的步骤，将一个或多个探针分子施加到所述多孔底物上，并且所述探针能够特异性结合所述一个或多个靶分子。 该方法还包括相对于彼此移动所述衬底和所述室的步骤，以迫使所述样品流体通过所述多孔衬底的孔并用所述一个或多个探针分子俘获所述一个或多个靶分子。 还公开了用于分析样品流体的传感器。

    Apparatus and method for a lysis of a sample, in particular for an automated and/or controlled lysis of a sample
    4.
    发明授权
    Apparatus and method for a lysis of a sample, in particular for an automated and/or controlled lysis of a sample 有权

    公开(公告)号：US09963670B2

    公开(公告)日：2018-05-08

    申请号：US14232391

    申请日：2011-07-27

    申请人： Andreas Boos ,  Gerd Lüdke ,  Johannes Bacher

    发明人： Andreas Boos ,  Gerd Lüdke ,  Johannes Bacher

    IPC分类号： C12M1/00 ,  G01N1/28 ,  G01N1/38 ,  G01N1/44 ,  C12N1/06 ,  G01N35/02 ,  G01N35/04 ,  G01N35/00

    CPC分类号： C12M47/06 ,  C12N1/066 ,  G01N1/286 ,  G01N1/38 ,  G01N1/44 ,  G01N35/025 ,  G01N2035/00504 ,  G01N2035/00524 ,  G01N2035/0441

    摘要： The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample. The apparatus comprises at least one rotation disc (31), at least one vial holder (90) which is configured to receive a vial (100), wherein the vial holder (90) is arranged on the disc (31), at least one driving device (20) which is configured to rotate the disc (31) and the vial holder (90), at least one heating device (60) which is configured to heat the sample to a determined incubation temperature, and—at least one control device (70) which is configured to control the driving device (20) and/or the heating device (60) by means of a timing and/or step control, and/or—at least one transmitting device (80) for inductive coupling for energy and signal transmission, which is configured to transmit the energy for heating to the heating device (60), and/or—wherein the driving device (20) is configured to rotate the disc (31) in a first direction (A1) and/or with a first speed, and to rotate the vial holder (90) in a second direction (A3) and/or with a second speed. The apparatus and the method are adapted for an (automated) lysis procedure, wherein the lysis can be carried out in a safe, efficient and effective manner.

    Reaction vessel for PCR device and method of performing PCR
    5.
    发明授权
    Reaction vessel for PCR device and method of performing PCR 有权
    用于PCR装置的反应容器和进行PCR的方法

    公开(公告)号：US09592511B2

    公开(公告)日：2017-03-14

    申请号：US13698805

    申请日：2011-05-19

    申请人： Gerd Lüdke ,  Andreas Boos ,  Hassan Motejadded ,  Johannes Bacher

    发明人： Gerd Lüdke ,  Andreas Boos ,  Hassan Motejadded ,  Johannes Bacher

    IPC分类号： B01L7/00 ,  B01L3/00

    CPC分类号： B01L7/52 ,  B01L3/502 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/047 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2400/0487 ,  B01L2400/049

    摘要： The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state. In the dry state the porous membrane (51) allows air as well as liquid to pass therethrough. In the wet state the porous membrane (51) still allows the passage of liquid therethrough, but not of air, such that during a PCR the liquid sample remains in the reaction chamber (33) and after the PCR the reaction vessel (20) is configured to force the liquid sample via the spacer element (42) to the porous membrane (51) for hybridization and detection of the at least one target DNA in the liquid sample. Moreover, a PCR device comprising such a reaction vessel (20) as well as a method for performing PCR are described.

    摘要翻译： 本发明提供一种用于PCR装置的反应容器（20）。 反应容器（20）包括限定用于进行PCR的反应室（33）的样品瓶（32）和限定用于光学检测的储存室（63）的储存容器（62）。 反应室（33）与液体供应口（34）流体连通，用于向反应室（33）供应含有至少一种目标DNA的液体样品。 反应室（33）和储存室（63）通过间隔元件（42）和多孔膜（51）流体连通，用于将液体样品中的至少一个目标DNA杂交到特定的固定化杂交探针上。 间隔元件（42）的下端延伸到反应室（33）中，但不到达其底部。 间隔元件（42）的上端位于多孔膜（51）附近，多孔膜（51）由干燥状态和潮湿状态下具有不同物理性质的材料制成。 在干燥状态下，多孔膜（51）允许空气以及液体通过。 在湿状态下，多孔膜（51）仍然允许液体通过其中而不是空气通过，使得在PCR期间液体样品保留在反应室（33）中，并且在PCR之后，反应容器（20）为 被配置为将液体样品经由间隔元件（42）强制到多孔膜（51），用于杂交和检测液体样品中的至少一种靶DNA。 此外，描述包含这种反应容器（20）的PCR装置以及进行PCR的方法。

    PATIENT IDENTIFICATION FOR POINT OF CARE DIAGNOSTICS
    6.
    发明申请
    PATIENT IDENTIFICATION FOR POINT OF CARE DIAGNOSTICS 审中-公开
    患者心脏诊断点患者识别

    公开(公告)号：US20090227897A1

    公开(公告)日：2009-09-10

    申请号：US11720875

    申请日：2005-12-05

    申请人： Matthias Wendt ,  Andreas Boos ,  Gerhard Spekowius ,  Peter K. Bachmann ,  Hans Nikol ,  Helga Hummel

    发明人： Matthias Wendt ,  Andreas Boos ,  Gerhard Spekowius ,  Peter K. Bachmann ,  Hans Nikol ,  Helga Hummel

    IPC分类号： A61B5/15 ,  C12Q1/68 ,  G06F7/04

    CPC分类号： G06F21/32 ,  A61B5/0002 ,  A61B5/117 ,  A61B5/1172 ,  A61B5/150022 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150786 ,  A61B5/15105 ,  A61B5/15186 ,  A61B10/0045 ,  A61B10/007 ,  A61B90/90 ,  G16H10/20

    摘要： A patient presses a finger concurrently against a needle (14) of a collection container (12) and a fingerprint surface (22, 52). In one embodiment, the patient's fingerprint is read electronically by a scanner (24) and correlated with a container serial number (16). In another embodiment, the patient's fingerprint is embossed in a foil layer (52). An analyzer assembly (40, 40′ 40″) analyzes the biological sample and reads either the container serial number or scans the fingerprint carrying layer (52) and sends the test results and either the fingerprint or container identification to a patient memory (30). Using the fingerprint information, a processor (32) correlates the test results with a record (60) of a corresponding patient. Alternately or additionally, the analyzer assembly includes a DNA analyzer (70) which measures preselected DNA characteristics (76) of the sample. The processor (32) compares the measured DNA subset characteristics with DNA subset characteristics (66) in the patient records to correlate or confirm the correlation of the analysis results with the proper patient.

    摘要翻译： 患者将手指同时按压在收集容器（12）的针头（14）和指纹表面（22,52）上。 在一个实施例中，患者的指纹由扫描仪（24）电子读取并与容器序列号（16）相关联。 在另一个实施例中，患者的指纹被压印在箔层（52）中。 分析器组件（40,40'40“）分析生物样品并读取容器序列号或扫描指纹携带层（52），并将测试结果和指纹或容器标识发送到患者存储器（30 ）。 使用指纹信息，处理器（32）将测试结果与相应患者的记录（60）相关联。 或者或另外，分析器组件包括测量样品的预选DNA特征（76）的DNA分析器（70）。 处理器（32）将所测量的DNA子集特征与患者记录中的DNA子集特征（66）进行比较，以将分析结果与适当患者的相关性相关联或确认。

    INTEGRATED TEMPERATURE SENSOR
    7.
    发明申请
    INTEGRATED TEMPERATURE SENSOR 审中-公开
    集成温度传感器

    公开(公告)号：US20090180516A1

    公开(公告)日：2009-07-16

    申请号：US12299124

    申请日：2007-05-01

    申请人： Jacob Marinus Jan Den Toonder ,  Andreas Boos

    发明人： Jacob Marinus Jan Den Toonder ,  Andreas Boos

    IPC分类号： G01K5/48

    CPC分类号： G01K5/486

    摘要： A biochip has an integrated temperature sensor comprising a micro mechanical actuator (20) having a deformation dependent on temperature, and a detector (30) arranged to output a signal according to a deformation of the actuator. The actuator can be formed of LC material in an elastomeric network. The detector (30) can be optical, magnetic or capacitive. The actuator can be arranged as a layer and the deformation be a curling of the layer.

    摘要翻译： 生物芯片具有集成的温度传感器，其包括具有取决于温度的变形的微机械致动器（20），以及检测器（30），其布置成根据致动器的变形输出信号。 致动器可以由弹性体网络中的LC材料形成。 检测器（30）可以是光学的，磁性的或电容的。 致动器可以被布置为层，并且变形是层的卷曲。

    Method and apparatus for calculating the fetal heart rate
    8.
    发明授权
    Method and apparatus for calculating the fetal heart rate 失效
    用于计算胎儿心率的方法和装置

    公开(公告)号：US5170791A

    公开(公告)日：1992-12-15

    申请号：US676886

    申请日：1991-03-28

    申请人： Andreas Boos ,  Martin Schraag

    发明人： Andreas Boos ,  Martin Schraag

    IPC分类号： A61B8/02 ,  G01S15/58 ,  G06F17/00

    CPC分类号： G01S15/582 ,  A61B8/02 ,  A61B8/0866

    摘要： Determining the fetal heart rate comprises irradiating an ultrasound beam in the direction of the fetal heart. The moving parts of the fetal heart cause a Doppler shift which is used to determine the fetal heart rate via an autocorrelation function. Moving parts of the fetal heart with different velocities and Doppler shifts originating from other physiological sources generate secondary maxima in the autocorrelation function, so that an accurate heart rate determination becomes nearly impossible. This problem is overcome by parallel processing of the demodulated ultrasound signal in various pass-bands, for which purpose the signal is fed to filters (28, 30) of different frequency characteristics. The output of the pass band with the better result is used for fetal heart rate circulation.

    摘要翻译： 确定胎儿心率包括在胎儿心脏的方向照射超声波束。 胎心的运动部分引起多普勒频移，用于通过自相关函数确定胎心率。 以不同速度运动的心脏心脏部分和源自其他生理源的多普勒频移在自相关函数中产生二次最大值，从而几乎不可能进行准确的心率测定。 通过在各种通带中解调的超声信号的并行处理来克服这个问题，为此，信号被馈送到具有不同频率特性的滤波器（28,30）。 胎儿心率循环使用带通效果较好的输出。

    REACTION VESSEL FOR PCR DEVICE AND METHOD OF PERFORMING PCR
    9.
    发明申请
    REACTION VESSEL FOR PCR DEVICE AND METHOD OF PERFORMING PCR 有权
    用于PCR装置的反应容器和执行PCR的方法

    公开(公告)号：US20130130267A1

    公开(公告)日：2013-05-23

    申请号：US13698805

    申请日：2011-05-19

    申请人： Gerd Lüdke ,  Andreas Boos ,  Hassan Motejadded ,  Johannes Bacher

    发明人： Gerd Lüdke ,  Andreas Boos ,  Hassan Motejadded ,  Johannes Bacher

    IPC分类号： B01L7/00

    CPC分类号： B01L7/52 ,  B01L3/502 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/047 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2400/0487 ,  B01L2400/049

    摘要： The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) for optical detection. The reaction chamber (33) is in fluid communication with a liquid supply port (34) for supplying a liquid sample containing at least one target DNA to the reaction chamber (33). The reaction chamber (33) and the storage chamber (63) are in fluid communication via a spacer element (42) and a porous membrane (51) for hybridization of the at least one target DNA within the liquid sample onto specific immobilised hybridization probes. The lower end of the spacer element (42) extends into the reaction chamber (33), but does not reach the bottom thereof. The upper end of the spacer element (42) is located in proximity of the porous membrane (51), which is made from a material having different physical properties in a dry state and a wet state. In the dry state the porous membrane (51) allows air as well as liquid to pass therethrough. In the wet state the porous membrane (51) still allows the passage of liquid therethrough, but not of air, such that during a PCR the liquid sample remains in the reaction chamber (33) and after the PCR the reaction vessel (20) is configured to force the liquid sample via the spacer element (42) to the porous membrane (51) for hybridization and detection of the at least one target DNA in the liquid sample. Moreover, a PCR device comprising such a reaction vessel (20) as well as a method for performing PCR are described.

    摘要翻译： 本发明提供一种用于PCR装置的反应容器（20）。 反应容器（20）包括限定用于进行PCR的反应室（33）的样品瓶（32）和限定用于光学检测的储存室（63）的储存容器（62）。 反应室（33）与液体供应口（34）流体连通，用于向反应室（33）供应含有至少一种目标DNA的液体样品。 反应室（33）和储存室（63）通过间隔元件（42）和多孔膜（51）流体连通，用于将液体样品中的至少一个目标DNA杂交到特定的固定化杂交探针上。 间隔元件（42）的下端延伸到反应室（33）中，但不到达其底部。 间隔元件（42）的上端位于多孔膜（51）附近，多孔膜（51）由干燥状态和潮湿状态下具有不同物理性质的材料制成。 在干燥状态下，多孔膜（51）允许空气以及液体通过。 在湿状态下，多孔膜（51）仍然允许液体通过其中而不是空气通过，使得在PCR期间液体样品保留在反应室（33）中，并且在PCR之后，反应容器（20）为 被配置为将液体样品经由间隔元件（42）强制到多孔膜（51），用于杂交和检测液体样品中的至少一种靶DNA。 此外，描述包含这种反应容器（20）的PCR装置以及进行PCR的方法。

    Telemetry system with transmitter holding position assignment
    10.
    发明授权
    Telemetry system with transmitter holding position assignment 有权
    遥测系统，带发射机保持位置分配

    公开(公告)号：US06968160B2

    公开(公告)日：2005-11-22

    申请号：US09758542

    申请日：2001-01-12

    申请人： Andreas Boos ,  Werner Jacoby ,  Markus Wollschlager

    发明人： Andreas Boos ,  Werner Jacoby ,  Markus Wollschlager

    IPC分类号： G08C19/00 ,  A61B5/00 ,  A61B5/04 ,  G08C17/00 ,  G08C17/02 ,  H04B1/08 ,  H04M11/00 ,  H04Q9/00 ,  H04Q9/10 ,  H04B1/38

    CPC分类号： H04Q9/10 ,  G08C17/02

    摘要： Disclosed is a telemetry system (10) with a receiver unit (50) and a plurality of transmitters (20–40), each adapted for providing a wireless communicating with the receiver unit (50). The receiver unit (50) comprises a plurality of transmitter holding positions (52–56), such as insertion slots, for receiving one of the transmitters (20–40), and means for assigning one of the transmitter holding positions (52–56) to the transmitter (20–40) received in the assigned transmitter holding position (52–56).

    摘要翻译： 公开了一种具有接收机单元（50）和多个发射机（20-40）的遥测系统（10），每个发射机适于提供与接收机单元（50）的无线通信。 接收器单元（50）包括用于接收发射器（20-40）中的一个的多个发射器保持位置（52-56），例如插入槽，以及用于分配发射机保持位置之一（52-56） ）到在分配的发射机保持位置（52-56）中接收的发射机（20-40）。