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    Amide derivatives
    4.
    发明授权
    Amide derivatives 失效
    酰胺衍生物

    公开(公告)号：US4528282A

    公开(公告)日：1985-07-09

    申请号：US459143

    申请日：1983-01-19

    申请人： John Preston ,  William R. Carling

    发明人： John Preston ,  William R. Carling

    IPC分类号： C07D317/30 ,  A61K38/00 ,  A61K45/06 ,  A61P9/12 ,  C07D207/16 ,  C07D307/54 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07K5/02 ,  A61K37/00 ,  C07C103/52

    CPC分类号： C07K5/0222 ,  A61K38/00 ,  Y10S530/80

    摘要： Amide derivatives of the formula: ##STR1## wherein either R.sup.1 is aryl or heterocyclic and A.sup.1 is a direct link, or R.sup.1 is aryl or heterocyclic, or hydrogen, or halogeno, hydroxy, amino, guanidino, mercapto, carboxy, carbamoyl, or a substituted derivative thereof, and A.sup.1 is alkylene, alkenylene, cycloalkylene or cycloalkenylene; wherein X is carbonyl or hydroxymethylene or substituted derivatives thereof; wherein A.sup.2 is alkylene, alkenylene or alkylidene; wherein R.sup.2 is hydrogen or alkyl which is unsubstituted or which bears an aryl substituent, or R.sup.2 has the formula --Q.sup.2 --R.sup.20 as defined below; wherein R.sup.3 is hydrogen, alkyl or a carbonyl-containing group; wherein R.sup.4 is hydrogen or alkyl which is unsubstituted or which bears a halogeno, hydroxy, amino, guanidino, carboxy, carbamoyl, mercapto, alkoxy, alkylamino, dialkylamino, cyclic amino, alkylthio, alkanoylamino, alkoxycarbonylamino, alkoxycarbonyl, alkoxycarbonyl, aryl or heterocyclyl substituent;wherein --NR.sup.5 --CR.sup.6 R.sup.16 --Q.sup.1 --R.sup.10 is an amino acid residue, R.sup.5, R.sup.6 and R.sup.16 being defined in claim 1, wherein Q.sup.1 and Q.sup.2, which may be the same or different, each is carbonyl (--CO--) or methylene (--CH.sub.2 --); and wherein R.sup.10 and R.sup.20, which may be the same or different, is hydroxy, amino or a substituted derivative thereof or hydroxyamino or arylthio; or a salt thereof where appropriate; processes for their manufacture and pharmaceutical compositions containing them. The compounds are inhibitors of angiotensin converting enzyme and may be used in the treatment of hypertension.

    摘要翻译： 下式的酰胺衍生物：其中R 1为芳基或杂环，且A 1为直链，或R 1为芳基或杂环，或氢或卤素，羟基，氨基，胍基，巯基，羧基，氨基甲酰基或 取代衍生物，A1为亚烷基，亚烯基，亚环烷基或环亚烯基; 其中X是羰基或羟基亚甲基或其取代的衍生物; 其中A2是亚烷基，亚烯基或亚烷基; 其中R 2是氢或未被取代或带有芳基取代基的烷基，或R 2具有如下定义的式-Q 2 -R 20; 其中R3是氢，烷基或含羰基的基团; 羟基，氨基，胍基，羧基，氨基甲酰基，巯基，烷氧基，烷基氨基，二烷基氨基，环状氨基，烷硫基，烷酰基氨基，烷氧基羰基氨基，烷氧基羰基，烷氧基羰基，芳基或杂环基取代基 ; 其中-NR5-CR6R16-Q1-R10是氨基酸残基，R5，R6和R16如权利要求1所定义，其中Q1和Q2可以相同或不同，分别为羰基（-CO-）或亚甲基（-CO-） -CH2-）; 并且其中R10和R20可以相同或不同，为羟基，氨基或其取代的衍生物或羟基氨基或芳硫基; 或其盐; 其制造方法和含有它们的药物组合物。 该化合物是血管紧张素转换酶的抑制剂，可用于治疗高血压。

    6-Substituted-4-hydroxycinnolin-3-yl-carboxylic acids and esters thereof
    5.
    发明授权
    6-Substituted-4-hydroxycinnolin-3-yl-carboxylic acids and esters thereof 失效
    6-取代的4-羟基噌啉-3-基 - 羧酸及其酯

    公开(公告)号：US4085103A

    公开(公告)日：1978-04-18

    申请号：US794114

    申请日：1977-05-05

    申请人： John Preston ,  Austin John Reeve

    发明人： John Preston ,  Austin John Reeve

    IPC分类号： C07D237/28

    CPC分类号： C07D237/28

    摘要： 6-Dimethylamino-4-hydroxycinnolin-3-yl carboxylic acid; ethyl 6-n-but-2-ylamino-4-hydroxycinnolin-3-yl carboxylate or the pharmaceutically-acceptable acid-addition salts thereof. The compounds are active as inhibitors of effects following the combination of reagin-like antibodies and their antigens.

    摘要翻译： 6-二甲基氨基-4-羟基噌啉-3-基羧酸; 6-正丁基-2-基氨基-4-羟基噌啉-3-基甲酸乙酯或其药学上可接受的酸加成盐。 这些化合物作为抑制剂作为效应的抑制剂，与抗原样抗体及其抗原组合。

    Method and apparatus for organizing and scheduling multimedia data transfers over a wireless channel
    7.
    发明申请
    Method and apparatus for organizing and scheduling multimedia data transfers over a wireless channel 审中-公开

    公开(公告)号：US20060092910A1

    公开(公告)日：2006-05-04

    申请号：US11299136

    申请日：2005-12-08

    申请人： Gregory Dertz ,  Alan Conrad ,  Robert LoGalbo ,  John Preston ,  Tyrone Bekiares ,  Donald Newberg

    发明人： Gregory Dertz ,  Alan Conrad ,  Robert LoGalbo ,  John Preston ,  Tyrone Bekiares ,  Donald Newberg

    IPC分类号： H04B7/212

    CPC分类号： H04W72/1242

    摘要： A radio frequency communications system (100) includes wireless terminals (102) and base sites (104). The wireless terminals communicate with the base sites over a radio frequency channel (106). The base sites are interconnected to each other and other network elements via a packet network. The communication system has a radio frequency channel (400) with time slots (406, 408) for transmission of both delay-sensitive data, such as streaming audio and video, and non-delay-sensitive data. A method and apparatus are provided for determining whether a time slot in the radio frequency channel is to be allocated to delay-sensitive data or non-delay-sensitive data (704, 706, 708). Each packet of data transmitted over the wireless channel has a type of service field (900). The type of service field has a precedence or priority value (902) and a service type (904). The priority values are used to determine which packet should be transmitted across the radio frequency channel next and the service type determines the transmission protocol.

    (Hetero) aryl-sulfonamide derivatives, their preparation and their use as factor XA inhibitors
    8.
    发明授权
    (Hetero) aryl-sulfonamide derivatives, their preparation and their use as factor XA inhibitors 失效
    （杂芳基）磺酰胺衍生物，它们的制备及其作为因子XA抑制剂的用途

    公开(公告)号：US06486154B1

    公开(公告)日：2002-11-26

    申请号：US09463446

    申请日：2000-01-27

    申请人： Andrew Stocker ,  John Preston

    发明人： Andrew Stocker ,  John Preston

    IPC分类号： A61K3154

    CPC分类号： C07D401/04

    摘要： A compound of formula (I), or a pharmaceutically-acceptable salt thereof, wherein A is an optionally substituted 5- or 6-membered monocyclic aromatic ring containing 1, 2 or 3 ring heteroatoms; B is optionally substituted phenylene or a 6-membered heterocyclic ring containing 1, 2 or 3 nitrogen heteroatoms; R and R1 are hydrogen or (1-4C)alkyl; n is 1 or 2; R2 and R3 are hydrogen, (1-6C)alkyl, (4-7C)cycloalkyl, or (2-6C)alkenyl, or R2 and R3 may form along with the nitrogen to which they are attached a 5-, 6- or 7-membered heterocyclic ring, wherein each R2 or R3 group or any heterocyclic ring formed from R2 and R3 may be optionally substituted with various substituent groups, and wherein Q may be optionally substituted by various substituent groups, which posseses antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention relates to processes for the preparation of the compounds represented by formula (I), to pharmaceutical compositions containing them, and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.

    摘要翻译： 式（I）化合物或其药学上可接受的盐，其中A是含有1,2或3个环杂原子的任选取代的5元或6元单环芳环; B是任选取代的亚苯基或含有1,2或3个氮杂原子的6元杂环; R和R 1是氢或（1-4C）烷基; n为1或2; R2和R3是氢，（1-6C）烷基，（4-7C）环烷基或（2-6C）烯基，或R2和R3可以与它们所连接的氮一起形成5-，6-或 7元杂环，其中每个R 2或R 3基团或由R 2和R 3形成的任何杂环可以任选被各种取代基取代，并且其中Q可任选地被各种取代基取代，这些取代基具有抗血栓形成和抗凝血性质， 因此在治疗人或动物的方法中有用。 本发明涉及制备由式（I）表示的化合物的方法，含有它们的药物组合物及其在制备用于产生抗血栓形成或抗凝血作用的药物中的用途。

    System and method for sheet measurement and control in papermaking machine
    10.
    发明授权
    System and method for sheet measurement and control in papermaking machine 有权
    造纸机纸张测量与控制系统及方法

    公开(公告)号：US6126785A

    公开(公告)日：2000-10-03

    申请号：US301340

    申请日：1999-04-29

    申请人： Hung-Tzaw Hu ,  Lee Chase ,  John Goss ,  John Preston

    发明人： Hung-Tzaw Hu ,  Lee Chase ,  John Goss ,  John Preston

    IPC分类号： D21F3/02 ,  D21F7/00 ,  D21G9/00 ,  D21F11/00

    CPC分类号： D21G9/0027 ,  D21F7/003 ,  Y10S162/10 ,  Y10S162/11

    摘要： Significant improvements in papermaking control can be achieved by employing an array of sensors that are positioned underneath the wire of the machine to measure the conductivity of the aqueous wet stock. The conductivity of the wet stock is directly proportional to the total water weight within the wet stock; consequently, the sensor provides information which can be used to monitor and control the quality of the paper sheet produced. Because CD water weight profile is obtained practically instantaneously, the MD and CD variations are essentially decoupled. Quality improvements to the sheet fabricated will be achieved by providing fast control of the actuators on the machine and by tuning components on the machine to eliminate the sources of variations. Further, the dry stock weight of a sheet of wet stock that is resting on a water permeable moving wire of the papermaking machine can be made employing a water weight sensor element that is positioned adjacent to the wire and that generates signals indicative of the water weight of the sheet of wet stock on the wire. Moreover, the moisture level cross-direction (CD) profile of a sheet of material that is produced can also be measured.

    摘要翻译： 通过使用位于机器线材下方的传感器阵列来测量水性湿料的导电性，可以实现造纸控制的显着改进。 湿料的电导率与湿料中的总水重量成正比; 因此，传感器提供可用于监测和控制所生产的纸张的质量的信息。 因为CD水重量曲线实际上是瞬间获得的，所以MD和CD变化基本上是去耦的。 通过对机器上的致动器进行快速控制，并通过调节机器上的组件来消除变化的来源，可以实现对制造的片材的质量改进。 此外，搁置在造纸机的透水移动金属线上的湿料片材的干燥储存重量可以使用位于铅丝附近的水重量传感器元件来制造，并产生指示水重量的信号 的电线上的湿股票。 此外，还可以测量所生产的材料片的湿度水平横向（CD）轮廓。