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公开(公告)号：US20220081661A1
公开(公告)日：2022-03-17
申请号：US17532196
申请日：2021-11-22
Applicant: CORNING INCORPORATED
Inventor： Ye Fang , Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Allison Jean Tanner , Qi Wu
Abstract: A cell culture apparatus may include a substrate defining a well. The well may define an interior surface, an exterior surface, an upper aperture and a nadir. The substrate may define a thickness between the interior and exterior surfaces that has a thickness proximate the nadir that is greater than or equal to a thickness proximate the upper aperture.
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公开(公告)号：US20210291173A1
公开(公告)日：2021-09-23
申请号：US17266242
申请日：2019-07-30
Applicant: CORNING INCORPORATED
Inventor： Ye Fang , Joydeep Lahiri , Georges Roussos , Paul Michael Then
IPC: B01L3/00
Abstract: A microfluidic device includes a first substrate comprising a surface, a flow channel disposed in the first substrate such that a sidewall of the flow channel extends between a floor of the flow channel and the surface, a film disposed on the floor of the flow channel, an array of wells disposed in the film, and a second substrate bonded to the surface of the first substrate, whereby the second substrate at least partially covers the flow channel.
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公开(公告)号：US20210062142A1
公开(公告)日：2021-03-04
申请号：US17022764
申请日：2020-09-16
Applicant: CORNING INCORPORATED
Inventor： Ye Fang , Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , David Henry , Martial Hervy , Corinne Walerack , Yue Zhou
IPC: C12N5/00 , C08J3/24 , C09D167/00
Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.
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公开(公告)号：US10647962B2
公开(公告)日：2020-05-12
申请号：US15602819
申请日：2017-05-23
Applicant: Corning Incorporated
Inventor： Huayun Deng , Ye Fang , Qiang Fu , John Christopher Mauro
Abstract: An aluminoborate glass composition, including B2O3, Al2O3, P2O5, Na2O, and CaO, as defined herein. Also disclosed are bioactive compositions including the disclosed aluminoborate glass composition, a suitable fluid, and at least one live cell. Also disclosed is method of limiting the amount of boron released into an aqueous solution from a disclosed aluminoborate-containing glass composition as defined herein. Also disclosed is a method of proliferating cells on a bioactive substrate as defined herein.
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公开(公告)号：US20190322969A1
公开(公告)日：2019-10-24
申请号：US16447453
申请日：2019-06-20
Applicant: Corning Incorporated
Inventor： Ye Fang , Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Gregory Roger Martin , Kaitlyn Mary Matias , Michael Kurt Schaefer , Allison Jean Tanner
Abstract: The present disclosure relates to apparatuses, systems and methods for culturing cells. In particular, devices and methods are provided for generation and culture of 3d cell aggregates.
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Patent Agency Ranking
公开(公告)号：US10203320B2
公开(公告)日：2019-02-12
申请号：US14437275
申请日：2013-11-15
Applicant: Corning Incorporated
Inventor： Oberon Denaci Deichmann , Ye Fang , Ann MeeJin Ferrie , David Henry , Haibei Hu , Corinne Walerack , Qi Wu
Abstract: A label-free resonant waveguide grating biosensor imager system for measuring beat patterns and dynamic mass redistribution (DMR) signals of cultured cardiomyocytes in the absence and presence of a drug molecule. The disclosure also provides a method using the imager system for analyzing the beat patterns and the DMR signals of the cardiomyocytes to assess drug-induced cardiotoxicity.
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公开(公告)号：US12203059B2
公开(公告)日：2025-01-21
申请号：US17532196
申请日：2021-11-22
Applicant: CORNING INCORPORATED
Inventor： Ye Fang , Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Allison Jean Tanner , Qi Wu
Abstract: A cell culture apparatus may include a substrate defining a well. The well may define an interior surface, an exterior surface, an upper aperture and a nadir. The substrate may define a thickness between the interior and exterior surfaces that has a thickness proximate the nadir that is greater than or equal to a thickness proximate the upper aperture.
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公开(公告)号：US11667906B2
公开(公告)日：2023-06-06
申请号：US14950771
申请日：2015-11-24
Applicant: Corning Incorporated
Inventor： Stephen Joseph Caracci , Ye Fang , Ann MeeJin Ferrie , Yan Jin , Lingyan Wang , Yue Zhou
Abstract: Magnetic microcarrier beads have a particle size of 1 to 1000 micrometers and include a composite core and a polymer coating that surrounds and encapsulates the core. The composite core includes magnetic particles embedded within an indigestible polymer matrix. The coating is a digestible or indigestible polymer that facilitates cell adhesion to the surface of the beads during cell culture. Magnetic force can be used to agitate the microcarrier beads during cell culture as well as to separate the beads from cultured cells or processed bio-media.
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公开(公告)号：US10676713B2
公开(公告)日：2020-06-09
申请号：US15602899
申请日：2017-05-23
Applicant: Corning Incorporated
Inventor： Huayun Deng , Ye Fang , Qiang Fu , Aize Li , Lina Ma , John Christopher Mauro
IPC: C12N5/00 , C03C3/145 , C03C4/00 , C03C3/16 , C03C3/21 , C03C3/062 , C03C3/17 , C03C3/064 , C03C3/19 , C12N5/071
Abstract: A borophosphate glass composition including B2O3, P2O5, and CaO, and optionally a source additive selected from: Li2O, Na2O, K2O, Al2O3, ZnO, MgO, Fe2O3/FeO, CuO/Cu2O, and mixtures thereof, as defined herein. Also disclosed are bioactive compositions or substrates including the disclosed borophosphate glass composition, and at least one live cell. Also disclosed are methods of inhibiting or increasing the relative amount of species containing boron, phosphorous, or both, being released into an aqueous solution from aborophosphate glass composition defined herein. Also disclosed is a method of proliferating cells on a bioactive substrate as defined herein. Also disclosed are related glass compositions that exclude one of B2O3, P2O5, and CaO.
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公开(公告)号：US20170349876A1
公开(公告)日：2017-12-07
申请号：US15602899
申请日：2017-05-23
Applicant: Corning Incorporated
Inventor： Huayun Deng , Ye Fang , Qiang Fu , Aize Li , Lina Ma , John Christopher Mauro
CPC classification number: C12N5/0068 , C03C3/062 , C03C3/064 , C03C3/145 , C03C3/16 , C03C3/17 , C03C3/19 , C03C3/21 , C03C4/0007 , C03C4/0014 , C03C4/0035 , C12N5/069 , C12N2500/30 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/30 , C12N2501/91 , C12N2533/12
Abstract: A borophosphate glass composition including B2O3, P2O5, and CaO, and optionally a source additive selected from: Li2O, Na2O, K2O, Al2O3, ZnO, MgO, Fe2O3/FeO, CuO/Cu2O, and mixtures thereof, as defined herein. Also disclosed are bioactive compositions or substrates including the disclosed borophosphate glass composition, and at least one live cell. Also disclosed are methods of inhibiting or increasing the relative amount of species containing boron, phosphorous, or both, being released into an aqueous solution from aborophosphate glass composition defined herein. Also disclosed is a method of proliferating cells on a bioactive substrate as defined herein. Also disclosed are related glass compositions that exclude one of B2O3, P2O5, and CaO.
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