-
公开(公告)号：US12202899B2
公开(公告)日：2025-01-21
申请号：US17256999
申请日：2019-07-14
Applicant: Development Center for Biotechnology
Inventor： Cheng-Chou Yu , Shih-Rang Yang , Tsung-Han Hsieh , Mei-Chi Chan , Shu-Ping Yeh , Chuan-Lung Hsu , Ling-Yueh Hu , Chih-Lun Hsiao
Abstract: An anti-PD-L1 antibody, or an antigen-binding fragment thereof, comprising: a heavy chain variable region comprising the three CDRs with the sequences of SEQ ID NOs: 2-4, 6-8, 10-12, 14-16, or 18-20; and/or a light chain variable region comprising the three CDRs with the sequences of SEQ ID NOs: 22-24, 26-28, 30-32, 34-36, or 38-40, wherein the antibody is a chimeric, humanized, composite, or human antibody.
-
Patent Agency Ranking
公开(公告)号：US20170369525A1
公开(公告)日：2017-12-28
申请号：US15541020
申请日：2015-12-31
Applicant: Development Center for Biotechnology , DCB-USA LLC
Inventor： Chao-Pin Lee , Cheng-Chou Yu , Chi-Huey Wong , Chuan-Lung Hsu , Chun-Chung Lee , Shih-Hsien Chuang , Ta-Tung Yuan , Yi-Jen Chen , Yu-Chin Nieh
IPC: C07K1/107 , C07K1/08 , A61K39/395 , C07K16/18 , A61K47/68
CPC classification number: C07K1/1077 , A61K39/395 , A61K47/6803 , A61K47/6855 , A61K47/6889 , A61K49/0043 , A61K49/0058 , C07K1/08 , C07K16/18
Abstract: A method for specific linkage to a glycoprotein includes obtaining a glycoprotein having a monoglycan or diglycan attached thereto; producing a reactive functional group on a sugar unit on the glycoprotein; and coupling a linker or a payload to the reactive functional group on the glycoprotein.
-
公开(公告)号：US10138300B2
公开(公告)日：2018-11-27
申请号：US15640935
申请日：2017-07-03
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： Jiann-Shiun Lai , Li-Shuang Ai , Yan-Da Lai , Yen-Yu Wu , Yi-San Tsai , Yi-Jiue Tsai , Juo-Yu Huang , Cheng-Chou Yu , Chuan-Lung Hsu , Chien-Tsun Kuan , Szu-Liang Lai , Li-Ya Wang
IPC: C07K16/28 , C07K16/30 , G01N33/74 , A61K51/10 , A61K31/4439 , C07K14/71 , C07K16/00 , A61K47/68 , A61K47/48 , A61K39/00
Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
-
公开(公告)号：US20180186884A1
公开(公告)日：2018-07-05
申请号：US15640935
申请日：2017-07-03
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： JIANN-SHIUN LAI , Li-Shuang Ai , Yan-Da Lai , Yen-Yu Wu , Yi-San Tsai , Yi-Jiue Tsai , Juo-Yu Huang , Cheng-Chou Yu , Chuan-Lung Hsu , Chien-Tsun Kuan , Szu-Liang Lai , Li-Ya Wang
IPC: C07K16/28 , G01N33/74 , C07K16/30 , A61K51/10 , A61K31/4439
CPC classification number: C07K16/2863 , A61K31/4439 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K51/1096 , A61K2039/505 , A61K2039/507 , C07K14/71 , C07K16/005 , C07K16/2818 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/74 , G01N2333/71
Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
-
公开(公告)号：US12091454B2
公开(公告)日：2024-09-17
申请号：US18089812
申请日：2022-12-28
Inventor： Cheng-Chou Yu , Shu-Ping Yeh , Chao-Yang Huang , Szu-Liang Lai , Shih-Liang Hsiao , Mei-Ling Hou , Tzung-Jie Yang , Wei-Ting Sun , Liang-Yu Hsia , Andrew Yueh , Chiung-Tong Chen , Ren-Huang Wu , Pei-Shan Wu , Han-Shu Hu , Tzu-Chin Wu , Jia-Ni Tian
CPC classification number: C07K16/28 , A61P35/00 , C12N15/63 , C07K2317/24 , C07K2317/31
Abstract: A humanized anti-neurotensin receptor 1 (NTSR1) antibody or an antigen-binding fragment thereof. Also, a method for treating, prophylactic treating and/or preventing diseases and/or disorders caused by or related to NTSR1 activity and/or signaling, and a method or kit for detecting NTSR1 in a sample.
-
公开(公告)号：US11998613B2
公开(公告)日：2024-06-04
申请号：US17339747
申请日：2021-06-04
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： Shih-Hsien Chuang , Wei-Ting Sun , Ying-Shuan Lailee , Chun-Liang Lai , Wun-Huei Lin , Win-Yin Wei , Shih-Chong Tsai , Cheng-Chou Yu , Chao-Yang Huang
CPC classification number: A61K47/6851 , A61K47/545 , A61K47/6803 , A61K47/6817 , A61K47/6889 , A61P35/00
Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.
-
-
-
-
-
Search Results
6
records
(took 0.014 seconds)
