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1.发明申请Apparatus and method for determining orientation parameters of an elongate object 有权用于确定细长物体的取向参数的装置和方法公开(公告)号：US20050195387A1
公开(公告)日：2005-09-08
申请号：US10796236
申请日：2004-03-08
CPC分类号： G01B11/002 , G01B11/272 , G01S17/46 , G06F3/0304 , G06F3/03545
摘要： An apparatus and method employing principles of stereo vision for determining one or more orientation parameters and especially the second and third Euler angles θ, ψ of an elongate object whose tip is contacting a surface at a contact point. The apparatus has a projector mounted on the elongate object for illuminating the surface with a probe radiation in a known pattern from a first point of view and a detector mounted on the elongate object for detecting a scattered portion of the probe radiation returning from the surface to the elongate object from a second point of view. The orientation parameters are determined from a difference between the projected and detected probe radiation such as the difference between the shape of the feature produced by the projected probe radiation and the shape of the feature detected by the detector. The pattern of probe radiation is chosen to provide information for determination of the one or more orientation parameters and can include asymmetric patterns such as lines, ellipses, rectangles, polygons or the symmetric cases including circles, squares and regular polygons. To produce the patterns the projector can use a scanning arrangement or a structured light optic such as a holographic, diffractive, refractive or reflective element and any combinations thereof. The apparatus is suitable for determining the orientation of a jotting implement such as a pen, pencil or stylus.
摘要翻译： 一种采用立体视觉原理的装置和方法，用于确定一个或多个取向参数，特别是尖端在接触点处接触表面的细长物体的第二和第三欧拉角θ，psi。 该装置具有安装在细长物体上的投影仪，用于从第一角度以已知图案的探测辐射照射表面，以及安装在细长物体上的检测器，用于检测从表面返回的探针辐射的散射部分 细长物体从第二个角度来看。 取向参数根据投射和检测的探针辐射之间的差异确定，例如由投射的探针辐射产生的特征的形状与由检测器检测到的特征的形状之间的差异。 选择探针辐射的图案以提供用于确定一个或多个取向参数的信息，并且可以包括不对称图案，例如线，椭圆，矩形，多边形或包括圆形，正方形和正多边形的对称情况。 为了产生图案，投影仪可以使用扫描装置或诸如全息衍射，折射或反射元件的结构化光学元件及其任何组合。 该装置适用于确定诸如笔，铅笔或触笔之类的记录工具的取向。
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2.发明申请Method and apparatus for determining absolute position of a tip of an elongate object on a plane surface with invariant features 有权用于确定具有不变特征的平面上的细长物体的尖端的绝对位置的方法和装置公开(公告)号：US20050133700A1
公开(公告)日：2005-06-23
申请号：US10745371
申请日：2003-12-22
CPC分类号： G06F3/03545 , G06F3/0321
摘要： A method and apparatus for determining a pose of an elongate object and an absolute position of its tip while the tip is in contact with a plane surface having invariant features. The surface and features are illuminated with a probe radiation and a scattered portion, e.g., the back-scattered portion, of the probe radiation returning from the plane surface and the feature to the elongate object at an angle τ with respect to an axis of the object is detected. The pose is derived from a response of the scattered portion to the surface and the features and the absolute position of the tip on the surface is obtained from the pose and knowledge about the feature. The probe radiation can be directed from the object to the surface at an angle σ to the axis of the object in the form of a scan beam. The scan beam can be made to follow a scan pattern with the aid of a scanning arrangement with one or more arms and one or more uniaxial or biaxial scanners. Angle τ can also be varied, e.g., with the aid of a separate or the same scanning arrangement as used to direct probe radiation to the surface. The object can be a pointer, a robotic arm, a cane or a jotting implement such as a pen, and the features can be edges, micro-structure or macro-structure belonging to, deposited on or attached to the surface which the tip of the object is contacting.
摘要翻译： 一种用于在尖端与具有不变特征的平面接触的情况下，确定细长物体的姿态和其尖端的绝对位置的方法和装置。 表面和特征被探针辐射照射，并且探针辐射的散射部分（例如，背散射部分）从平面表面和特征向细长物体返回，其角度τ相对于 检测到物体。 姿势是从分散部分到表面的响应导出的，并且从关于特征的姿势和知识中获得尖端在表面上的特征和绝对位置。 探针辐射可以以扫描光束的形式从物体以角度与物体的轴线指向表面。 借助于具有一个或多个臂和一个或多个单轴或双轴扫描器的扫描装置，可以使扫描光束跟随扫描图案。 角度tau也可以变化，例如借助于将探针辐射引导到表面的单独或相同的扫描布置。 该物体可以是指针，机器人手臂，手杖或笔记本记录工具，并且特征可以是属于，沉积在或附着到表面上的边缘，微结构或宏观结构，其表面的尖端 对象正在联系。
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3.发明申请Apparatus and method for determining an inclination of an elongate object contacting a plane surface 失效用于确定接触平面的细长物体的倾斜度的装置和方法公开(公告)号：US20050107979A1
公开(公告)日：2005-05-19
申请号：US10701817
申请日：2003-11-04
CPC分类号： G06F3/03545
摘要： An apparatus and method for determining an inclination angle θ between an axis of an elongate object such as a cane, a pointer or a jotting implement such as a pen, pencil, stylus or the like and a normal to a plane surface at times when a tip of the elongate object is contacting that plane surface. The apparatus has an emitter mounted on the object for illuminating the plane surface with a probe radiation at an angle σ with respect to the axis of the object. The apparatus also has a detector mounted on the elongate object for detecting a radiation characteristic of a scattered portion of the probe radiation returning from the plane surface and a computing unit for deriving the inclination angle θ from the radiation characteristic. A scanning arrangement, such as a uniaxial or biaxial scanner, or a light guiding optic can be used for varying angle σ, and the probe radiation can be emitted in the form of a scan beam. Preferably, the emitter and detector of the scattered portion of the probe radiation are integrated and the scattered portion of the probe radiation whose characteristic is being measured is the back-scattered portion. The radiation characteristic detected by the detector can be the intensity, polarization, time-of-flight or any combination thereof.
摘要翻译： 一种用于确定细长物体的轴线之间的倾斜角度θ的装置和方法，所述细长物体诸如手杖，指针或诸如笔，铅笔，触笔等的记录工具以及在平面表面的法线 细长物体的尖端与该平面接触。 该装置具有安装在物体上的发射器，用于以相对于物体的轴线的角度σ来探测辐射照射平面。 该装置还具有安装在细长物体上的检测器，用于检测从平面表面返回的探针辐射的散射部分的辐射特性，以及用于从辐射特性导出倾斜角度θ的计算单元。 可以使用诸如单轴或双轴扫描仪或导光光学器件的扫描装置来改变角度，并且可以以扫描光束的形式发射探测辐射。 优选地，探测辐射的散射部分的发射极和检测器是一体的，并且其特征被测量的探测辐射的散射部分是反向散射部分。 由检测器检测的辐射特性可以是强度，极化，飞行时间或其任何组合。
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4.发明申请公开(公告)号：US20050280804A1
公开(公告)日：2005-12-22
申请号：US10871496
申请日：2004-06-18
申请人： Dale Buermann , Michael Mandella
发明人： Dale Buermann , Michael Mandella
摘要： An elongate object optically determines at least one of its orientation parameters relative to a plane surface. A probe radiation beam is directed from the object at various angles σ to various locations on the plane, where the angle σ is a periodic function of time. Two angularly-selective radiation detectors oriented at fixed angles τ1 and τ2 sense scattered portions of the beam from two locations a two corresponding times. The orientation parameter is computed from a time difference Δt=t2−t1 between the two times.
摘要翻译： 细长物体相对于平面表面光学地确定其取向参数中的至少一个。 探针辐射束以不同的角度从物体引导到平面上的各种位置，其中角度σ是时间的周期函数。 以固定角度τ1和τ2定向的两个角度选择性辐射探测器从两个位置感测来自两个对应时间的波束的散射部分。 方向参数是从两次之间的时间差Deltat = t 2 -t 1 1 <1>计算的。
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5.发明申请公开(公告)号：US20050225742A1
公开(公告)日：2005-10-13
申请号：US10824330
申请日：2004-04-13
申请人： Dale Buermann , Michael Mandella
发明人： Dale Buermann , Michael Mandella
摘要： An apparatus and a method are disclosed for optically determining a distance r to a feature from an origin or a center. The apparatus uses a beam generation unit for launching a reference beam on a reference path and a first beam on a first path. The center from which distance r is determined is selected such that it is along a line of the reference path and not along a line of the first path. Alternatively, the center can be chosen not to lie along a line of the reference path. A rotation mechanism rotates the reference path and the first path about the center such that the reference beam moves over the feature at a reference time tr and the first beam moves over the feature at a first time t1. A determination unit determines distance r between the center and the feature from an angular velocity ω of the reference beam over the feature and from times tr, t1.
摘要翻译： 公开了一种用于光学地确定从原点或中心到特征的距离r的装置和方法。 该装置使用光束产生单元，用于在参考路径上发射参考光束，并在第一路径上发射第一光束。 选择距离r确定的中心，使得其沿着参考路径的线并且不沿着第一路径的线。 或者，可以选择中心不能沿着参考路径的一条直线。 旋转机构使参考路径和第一路径围绕中心旋转，使得参考光束在参考时间t 1上移动到特征上，并且第一光束在第一时间t 1上移动到特征上， SUB> 1 。 确定单元根据特征和时间t 1，t 1 1从参考光束的角速度ω来确定中心和特征之间的距离r。
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公开(公告)号：US20120292190A1
公开(公告)日：2012-11-22
申请号：US13551704
申请日：2012-07-18
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： C25B7/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.
摘要翻译： 核酸分裂装置。 该装置包括包含具有核酸的流体的样品储存器。 该装置还可以包括位于样品容器内的剪切壁。 剪切壁包括多孔芯介质，其具有尺寸允许核酸流过其中的孔。 该装置还包括被剪力墙隔开的第一和第二室。 第一和第二腔室通过剪切壁的多孔纤维介质彼此流体连通。 此外，该装置可以包括分别位于第一和第二室内的第一和第二电极。 第一和第二电极被配置成产生诱发样品流体流动的电场。 核酸通过剪切壁移动，从而使核酸分裂。
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公开(公告)号：US20110072914A1
公开(公告)日：2011-03-31
申请号：US12031054
申请日：2008-02-14
申请人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
发明人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
CPC分类号： F04B19/006 , B01L3/502715 , B01L3/50273 , B01L7/00 , B01L2300/0816 , B01L2300/0877 , B01L2400/0418 , G01N35/00613 , G01N35/1095 , Y10T436/2575
摘要： A flows cell for use in a microfluidic detection system is provided. The flow cell includes a flows cell body having a channel that is configured to convey a solution through the flows cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.
摘要翻译： 提供了一种用于微流体检测系统的流通池。 流动池包括具有通道的流动池主体，该通道被配置为将溶液输送通过流动池主体。 流动池还包括底面和顶面。 底表面被构造成由检测系统可移除地保持，并且顶表面是透明的并且允许光通过。 流动池体还包括与通道流体连通的流体入口和出口。 在流动池主体中还设有泵腔。 泵腔与通道的端部和流体入口和出口之一流体连通并且介于其间。 电渗（EO）泵保持在泵腔中。 EO泵通过EO泵和流体入口和出口之间的通道引起溶液的流动。
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公开(公告)号：US6128085A
公开(公告)日：2000-10-03
申请号：US421449
申请日：1999-10-19
IPC分类号： G01B11/06 , G01J3/02 , G01J3/12 , G01J3/42 , G01J3/45 , G01J4/00 , G01N21/27 , G01N21/45 , G01N21/21
CPC分类号： G01J3/12 , G01B11/0625 , G01B11/0641 , G01J3/02 , G01J3/0208 , G01J3/42 , G01J4/00
摘要： An apparatus uses reflectance spectrophotometry to characterize a sample having any number of thin films. The apparatus uses two toroidal mirrors in an optical relay to direct light reflected by the sample to a spectroscopic device. A computer then analyzes the reflected spectrum to characterize the optical properties of the sample. The optical relay allows a range of angles of reflection from the sample, and has no chromatic aberration. The optical relay is also arranged so that the non-chromatic aberration is minimized. For polarization-based measurements polarizing elements can be used in the apparatus and the spectroscopic device can be a spectroscopic ellipsometer. The sample is mounted on a movable stage so that different areas of the sample may be characterized. Furthermore, a deflector and a viewer are used to allow the operator of the apparatus to view the region of the sample under study.
摘要翻译： 一种装置使用反射分光光度法来表征具有任何数量薄膜的样品。 该装置在光学继电器中使用两个环形反射镜来将由样品反射的光引导到光谱装置。 然后计算机分析反射光谱以表征样品的光学性质。 光学继电器允许来自样品的一定范围的反射角度，并且没有色差。 光学继电器也被布置成使得非色差最小化。 对于基于偏振的测量，偏振元件可以用在装置中，并且光谱装置可以是光谱椭偏仪。 将样品安装在可移动的载物台上，以便可以对样品的不同区域进行表征。 此外，偏转器和观察器用于允许装置的操作者观察正在研究的样品的区域。
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公开(公告)号：US08597594B2
公开(公告)日：2013-12-03
申请号：US13551704
申请日：2012-07-18
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain , Michael Schroeder
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain , Michael Schroeder
IPC分类号： B01L3/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.
摘要翻译： 核酸分裂装置。 该装置包括包含具有核酸的流体的样品储存器。 该装置还可以包括位于样品容器内的剪切壁。 剪切壁包括多孔芯介质，其具有尺寸允许核酸流过其中的孔。 该装置还包括被剪力墙隔开的第一和第二室。 第一和第二腔室通过剪切壁的多孔纤维介质彼此流体连通。 此外，该装置可以包括分别位于第一和第二室内的第一和第二电极。 第一和第二电极被配置成产生诱发样品流体流动的电场。 核酸通过剪切壁移动，从而使核酸分裂。
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10.发明授权Systems, methods, and apparatuses including a moveable optical component for detecting optical signals from a sample 有权包括用于检测来自样品的光信号的可移动光学部件的系统，方法和装置公开(公告)号：US08481903B2
公开(公告)日：2013-07-09
申请号：US13041194
申请日：2011-03-04
申请人： Alexander Triener , Erik Allegoren , Wenyi Feng , Dale Buermann , Erik Olson , James Osmus
发明人： Alexander Triener , Erik Allegoren , Wenyi Feng , Dale Buermann , Erik Olson , James Osmus
IPC分类号： G02B7/04
CPC分类号： C12Q1/6874 , C12Q1/6837 , G01N21/6428 , G01N21/645 , G01N21/6456
摘要： An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.
摘要翻译： 一种配置成在成像会话期间检测光信号的光学系统。 光学系统包括物镜，该物镜具有位于样品附近并被配置为从其接收光信号的收集端。 光学系统还包括被配置为位于物镜的收集端和样品之间的成像位置处的可移除路径补偿器。 路径补偿器在成像位置调整光发射的光路。 此外，光学系统包括被配置为移动路径补偿器的传送装置。 传送装置将路径补偿器定位在用于第一成像会话的成像位置处，并从第二成像会话的成像位置移除路径补偿器。
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