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公开(公告)号：US6001843A
公开(公告)日：1999-12-14
申请号：US181887
申请日：1998-10-29
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89 , A61K31/535 , C07D211/70 , C07D211/72 , C07D211/78
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号：US07060715B2
公开(公告)日：2006-06-13
申请号：US10916097
申请日：2004-08-11
IPC分类号： C07D213/22 , C07D211/72 , A61K31/435 , A61K31/44
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号：US06596736B2
公开(公告)日：2003-07-22
申请号：US10021187
申请日：2001-10-30
IPC分类号： A61K3144
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用。本发明还包括 用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：US6071936A
公开(公告)日：2000-06-06
申请号：US312790
申请日：1999-05-17
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号：US5861419A
公开(公告)日：1999-01-19
申请号：US893395
申请日：1997-07-11
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新型化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无效治疗有效量的式I化合物的患者给药。图像I 本发明还包括用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：US20100298347A1
公开(公告)日：2010-11-25
申请号：US12743610
申请日：2008-12-01
申请人： Michel Belley , Denis Deschenes , Rejean Fortin , Jean-Francois Fournier , Sebastien Gagne , Yves Gareau , Jacques Yves Gauthier , Lianhai Li , Joel Robichaud , Michel Therien , Geoffrey K. Tranmer , Zhaoyin Wang
发明人： Michel Belley , Denis Deschenes , Rejean Fortin , Jean-Francois Fournier , Sebastien Gagne , Yves Gareau , Jacques Yves Gauthier , Lianhai Li , Joel Robichaud , Michel Therien , Geoffrey K. Tranmer , Zhaoyin Wang
IPC分类号： A61K31/519 , C07C63/72 , C07D333/34 , C07D333/22 , C07C63/42 , C07D317/54 , C07D409/12 , C07D487/04 , C07D249/08 , C07D211/94 , C07D211/32 , A61K31/192 , A61K31/381 , A61K31/194 , A61K31/36 , A61K31/4436 , A61K31/4196 , A61K31/451 , A61P3/10 , A61P5/50 , A61P3/04 , A61P3/00
CPC分类号： C07D211/34 , C07C65/24 , C07C65/30 , C07C65/40 , C07C69/76 , C07C69/94 , C07C317/44 , C07C317/46 , C07C323/62 , C07D211/52 , C07D249/08 , C07D317/60 , C07D333/16 , C07D333/24 , C07D333/34 , C07D487/04
摘要： Substituted 2-naphthoic acids of structural formula are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and conditions associated with the Metabolic Syndrome.
摘要翻译： 结构式的取代的2-萘甲酸作为GPR105蛋白的生物活性的拮抗剂是有效的。 它们可用于治疗，控制或预防对该受体的拮抗作用有响应的病症，例如糖尿病，特别是2型糖尿病，胰岛素抵抗，高血糖症，脂质障碍，肥胖症，动脉粥样硬化和与代谢综合征有关的病症。
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7.发明授权Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors 失效具有含硫取代基的芳基二氟甲基膦酸作为PTP-1B抑制剂公开(公告)号：US06498151B2
公开(公告)日：2002-12-24
申请号：US09813489
申请日：2001-03-21
申请人： Chun Sing Li , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Cheuk Kun Lau , Patrick Roy , Michel Therien , Zhaoyin Wang , Claude Dufresne , Rejean Fortin
发明人： Chun Sing Li , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Cheuk Kun Lau , Patrick Roy , Michel Therien , Zhaoyin Wang , Claude Dufresne , Rejean Fortin
IPC分类号： C07D23995
CPC分类号： C07F9/65583 , A61K31/66 , A61K45/06 , C07F9/3882 , C07F9/4056 , C07F9/5537 , C07F9/58 , C07F9/59 , C07F9/60 , C07F9/6506 , C07F9/65068 , C07F9/6512 , C07F9/65128 , C07F9/6518 , C07F9/6524 , C07F9/65312 , C07F9/65318 , C07F9/6539 , C07F9/65395 , C07F9/6552 , C07F9/65522 , A61K2300/00
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译： 本发明包括由下式表示的新型化合物，其是PTP-1B酶的抑制剂。本发明还包括治疗或预防PTP-1B介导的疾病包括糖尿病的药物组合物和方法。
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8.发明授权Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) 失效作为蛋白酪氨酸磷酸酶1B（PTP-1B）的抑制剂的膦酸联芳衍生物公开(公告)号：US06486141B2
公开(公告)日：2002-11-26
申请号：US09745199
申请日：2000-12-21
申请人： Cheuk Kun Lau , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Chun Sing Li , Patrick Roy , Michel Therien , Zhaoyin Wang
发明人： Cheuk Kun Lau , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Chun Sing Li , Patrick Roy , Michel Therien , Zhaoyin Wang
IPC分类号： A61K31663
CPC分类号： C07F9/65583 , C07F9/65188
摘要： The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related conditions.
摘要翻译： 本发明包括作为PTP-1B酶抑制剂的由式I表示的新一类化合物。本发明还包括治疗或预防PTP-1B介导的疾病的药物组合物和方法，包括糖尿病，肥胖症和糖尿病相关病症 。
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公开(公告)号：US5767291A
公开(公告)日：1998-06-16
申请号：US738144
申请日：1996-10-25
申请人： Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
发明人： Yves Ducharme , Jacques Yves Gauthier , Petpiboon Prasit , Yves Leblanc , Zhaoyin Wang , Serge Leger , Michel Therien
摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
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10.发明授权Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) 失效作为蛋白酪氨酸磷酸酶1B（PTP-1B）抑制剂的膦酸衍生物公开(公告)号：US06486142B2
公开(公告)日：2002-11-26
申请号：US09745211
申请日：2000-12-21
申请人： Yves Leblanc , Claude Dufresne , Jacques Yves Gauthier , Cheuk Kun Lau , Chun Sing Li , Patrick Roy , Michel Therien , John Scheigetz , Zhaoyin Wang
发明人： Yves Leblanc , Claude Dufresne , Jacques Yves Gauthier , Cheuk Kun Lau , Chun Sing Li , Patrick Roy , Michel Therien , John Scheigetz , Zhaoyin Wang
IPC分类号： C07F938
CPC分类号： C07F9/6539 , C07F9/3882 , C07F9/4075 , C07F9/4087 , C07F9/65188 , C07F9/65318
摘要： The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and conditions related to diabetes.
摘要翻译： 本发明包括由式I表示的新型化合物，其是PTP-1B酶的抑制剂。本发明还包括治疗或预防PTP-1B介导的疾病的药物组合物和方法，包括糖尿病，肥胖症和与 糖尿病。
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