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    INFORMATION PROCESSING APPARATUS, CELL CULTURE SYSTEM, INFORMATION PROCESSING METHOD, AND INFORMATION PROCESSING PROGRAM
    1.
    发明申请
    INFORMATION PROCESSING APPARATUS, CELL CULTURE SYSTEM, INFORMATION PROCESSING METHOD, AND INFORMATION PROCESSING PROGRAM 有权

    公开(公告)号：US20210403855A1

    公开(公告)日：2021-12-30

    申请号：US17472730

    申请日：2021-09-13

    Applicant: FUJIFILM CORPORATION

    Inventor： Hidetoshi TAKAYAMA ,  Koju ITO ,  Takahiro OBA ,  Keisuke OKU

    IPC: C12M1/36 ,  G06N20/00 ,  C12M3/06 ,  C12M1/00 ,  C12M1/34

    Abstract: An information processing apparatus includes an acquisition unit that acquires an evaluation value for a state of cells which are cultured in each of a plurality of fluidic devices, culture environment, and information representing a disposition position of the fluidic device; and a generation unit that generates a learned model in which the evaluation value and the information representing the disposition position are received as an input and the culture environment is output, through machine learning using, as training data, the evaluation value before adjustment of the culture environment, the culture environment after the adjustment, and the information representing the disposition position, in a case where, due to the adjustment, the evaluation value becomes a first threshold value or more and an absolute value of a difference in evaluation value between the plurality of fluidic devices becomes a second threshold value or less.

    METHOD FOR PRODUCING CELL LAMINATE
    2.
    发明申请
    METHOD FOR PRODUCING CELL LAMINATE 审中-公开

    公开(公告)号：US20200095531A1

    公开(公告)日：2020-03-26

    申请号：US16695073

    申请日：2019-11-25

    Applicant: FUJIFILM CORPORATION

    Inventor： Masafumi NISHINO ,  Koju ITO ,  Shinji MIMA ,  Hayato MIYOSHI

    IPC: C12M1/12 ,  C12N5/071

    Abstract: Provided is a method for producing a cell laminate including cell layers on both surfaces of a porous membrane, using a vessel having a bottom portion and a side wall portion standing from a periphery of the bottom portion, the porous membrane, and a holding member configured to hold the porous membrane such that the porous membrane faces an inner bottom surface of the vessel and is held at a position that does not contact the inner bottom surface, the method including culturing first cells in a liquid medium that contacts the inner bottom surface of the vessel and a surface of the porous membrane, in a state in which the porous membrane is held, by the holding member, at a position that does not contact the inner bottom surface of the vessel so as to face the inner bottom surface, and in which the bottom portion of the vessel is positioned at the upper side while the porous membrane is positioned at the lower side in a direction of gravity; and culturing the first cells at a lower surface of the porous membrane and culturing second cells at an upper surface of the porous membrane, in a state in which the porous membrane is held, by the holding member, at a position that does not contact the inner bottom surface of the vessel so as to face the inner bottom surface, and in which the bottom portion of the vessel is positioned at the lower side while the porous membrane is positioned at the upper side in the direction of gravity.

    CELL CULTURE SYSTEM AND CELL CULTURE METHOD
    3.
    发明申请
    CELL CULTURE SYSTEM AND CELL CULTURE METHOD 有权

    公开(公告)号：US20210403847A1

    公开(公告)日：2021-12-30

    申请号：US17472729

    申请日：2021-09-13

    Applicant: FUJIFILM CORPORATION

    Inventor： Hidetoshi TAKAYAMA ,  Koju ITO ,  Takahiro OBA ,  Keisuke OKU

    IPC: C12M1/00 ,  B01L3/00 ,  B01L7/00 ,  C12M1/34 ,  C12M3/00 ,  C12M3/06 ,  C12M1/26 ,  C12M1/36

    Abstract: A cell culture system includes: a plurality of cell culture channels each of which includes a fluidic device in which cells are cultured, a pump which makes a liquid flow into the fluidic device, a detection unit which detects a state of the cells that are cultured, and a controller which controls the pump and the detection unit; a measurement unit that measures culture environment of the cells which are cultured in the plurality of cell culture channels; and an information processing apparatus that adjusts the culture environment such that an absolute value of a difference between evaluation values for the states of the cells that are cultured in the plurality of cell culture channels is a threshold value or less, on the basis of the state of the cells detected by the detection unit and the culture environment of the cells measured by the measurement unit.

    METHOD OF PRODUCING POROUS MOLDED BODY
    4.
    发明申请
    METHOD OF PRODUCING POROUS MOLDED BODY 审中-公开

    公开(公告)号：US20200347199A1

    公开(公告)日：2020-11-05

    申请号：US16936085

    申请日：2020-07-22

    Applicant: FUJIFILM Corporation

    Inventor： Keisuke OKU ,  Koju ITO ,  Hiroshi YABU ,  Yoshiaki UCHIDA

    IPC: C08J9/26 ,  C08J9/28 ,  C08J9/00

    Abstract: A molded body is produced from a molding material including a continuous phase and a dispersed phase by a three-dimensionalization step, a curing step, and a peeling step. The continuous phase of the molding material is a water phase containing a curable compound. In the three-dimensionalization step, the molding material is placed in a container. In the curing step, the curable compound is cured to form a cured product after the three-dimensionalization step. In the peeling step, the container and the cured product are separated after the curing step. In the dispersed phase removal step, the dispersed phase of the cured product is removed after the curing step.

    MEASUREMENT DEVICE, OPERATION PROGRAM FOR MEASUREMENT DEVICE, AND MEASUREMENT METHOD
    7.
    发明申请
    MEASUREMENT DEVICE, OPERATION PROGRAM FOR MEASUREMENT DEVICE, AND MEASUREMENT METHOD 有权

    公开(公告)号：US20220082503A1

    公开(公告)日：2022-03-17

    申请号：US17481329

    申请日：2021-09-22

    Applicant: FUJIFILM CORPORATION

    Inventor： Takahiro OGURA ,  Koju ITO

    IPC: G01N21/64

    Abstract: Provided is a measurement device including a mounting unit in which a flow channel device is attachably and detachably mounted, the flow channel device including a first flow channel, a second flow channel having a communicating portion that communicates with a part of the first flow channel, and a cell sheet in which a plurality of cultured cells are arranged in such a manner that the cells are bound to each other and which partitions between the first flow channel and the second flow channel at the communicating portion; and a detection unit that optically distinguishes and detects a leakage state of each of a plurality of types of tracers having different sizes and leaking out from the first flow channel into the second flow channel through a defect occurring in the cell sheet in a case where an evaluation liquid is fed into the first flow channel.

    METHOD OF PRODUCING POROUS MOLDED BODY
    8.
    发明申请
    METHOD OF PRODUCING POROUS MOLDED BODY 审中-公开

    公开(公告)号：US20200347198A1

    公开(公告)日：2020-11-05

    申请号：US16935874

    申请日：2020-07-22

    Applicant: FUJIFILM Corporation

    Inventor： Keisuke OKU ,  Koju ITO ,  Hiroshi YABU ,  Yoshiaki UCHIDA

    IPC: C08J9/26 ,  C08J5/18 ,  B29C41/02

    Abstract: A molding device produces a porous film from a molding material which is an emulsion. In a case where a volume of a dispersed phase is X1 and a volume of a continuous phase is X2, the molding material has a value of X1/(X1+X2) within a range of 0.5 or more and 0.9 or less. In the molding material, a specific gravity of the dispersed phase is greater than a specific gravity of the continuous phase. The molding material includes a water phase containing a curable compound as the continuous phase, and forms a liquid film on a support. Thereafter, the curable compound in the liquid film is cured. After curing, the dispersed phase is removed.

    BLOOD VESSEL MODEL
    9.
    发明申请
    BLOOD VESSEL MODEL 审中-公开

    公开(公告)号：US20180356399A1

    公开(公告)日：2018-12-13

    申请号：US15618151

    申请日：2017-06-09

    Applicant: FUJIFILM Corporation ,  The General Hospital Corporation

    Inventor： Koju ITO ,  Chihaya KAKINUMA ,  Shinji MIMA ,  Daichi HIKIMOTO ,  Craig M Neville ,  Cathryn A Sundback

    IPC: G01N33/50

    CPC classification number: G01N33/5088 ,  G01N33/5029 ,  G01N33/5064

    Abstract: The present disclosure provides a blood vessel model including: a pair of channel members, mutually opposing each other, each of which includes an opposing face in which a respective microchannel is formed; and a porous membrane that includes plural through-holes penetrating in a thickness direction, that is disposed between the opposing faces of the pair of channel members, and that partitions between the microchannels, wherein the porous membrane is provided with a vascular endothelial cell layer so as to cover one face facing one of the microchannels, an average opening diameter of the through-holes is from 1 μm to 20 μm, and an opening coverage ratio of the through-holes is from 30% to 70%.

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