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    Measuring device
    1.
    发明授权
    Measuring device 失效
    测量工具

    公开(公告)号：US06413474B1

    公开(公告)日：2002-07-02

    申请号：US09441769

    申请日：1999-11-17

    申请人： Günter Igel ,  Ulrich Sieben ,  Jürgen Giehl ,  Bernhard Wolf

    发明人： Günter Igel ,  Ulrich Sieben ,  Jürgen Giehl ,  Bernhard Wolf

    IPC分类号： G01N1506

    CPC分类号： G01L19/147 ,  H01L2224/16225 ,  H01L2924/00014 ,  H01L2224/0401

    摘要： A measuring device (1) has a semiconductor arrangement, which includes a semiconductor chip (2) connected to a carrier (4) having at least one through-hole (3). The semiconductor chip (2) has at least one sensor (6) with an active sensor surface (5) facing the through-hole (3). The semiconductor chip (2) has electrical terminal points (9), which are connected using flip-chip connections (10) to terminal contacts (11) facing the terminal points (9) and located on the carrier (4). The carrier (4) has electrical strip conductors (12), which connect the terminal contacts (11) to contact elements (13) located on the carrier. To the rear side of the carrier (4) having the contact elements (13) a strip conductor carrier (16) is provided, which has strip conductors (12) connected to opposing contacts (14). The opposing contacts (14) are each electrically connected using flip-chip connections (17), to a contact element (13), which are allocated to each of them. The semiconductor chip (2) and the carrier (4) enclose a measuring chamber. Between the carrier (4) and the semiconductor chip (2) a seal (7) is arranged, which is constructed to be porous or semi-porous, at least in certain areas, or is constructed as a selectively permeable membrane, for bringing a substance into the measuring chamber.

    摘要翻译： 测量装置（1）具有半导体装置，其包括连接到具有至少一个通孔（3）的载体（4）的半导体芯片（2）。 半导体芯片（2）具有至少一个具有面向通孔（3）的有源传感器表面（5）的传感器（6）。 半导体芯片（2）具有电气端点（9），它们使用倒装芯片连接（10）连接到面向终端点（9）并位于载体（4）上的端子触点（11）。 载体（4）具有将端子触点（11）连接到位于载体上的接触元件（13）的电条导体（12）。 在具有接触元件（13）的载体（4）的后侧设置带状导体载体（16），该带状导体载体（16）具有连接到相对触点（14）的带状导体（12）。 每个相对的触点（14）都使用倒装芯片连接（17）电连接到分配给它们中的每一个的接触元件（13）。 半导体芯片（2）和载体（4）包围测量室。 在载体（4）和半导体芯片（2）之间，至少在某些区域中布置密封件（7），其被构造为多孔或半孔的，或被构造为选择性渗透膜，用于使 物质进入测量室。

    Capacitive magnetic field sensor
    2.
    发明授权
    Capacitive magnetic field sensor 失效
    电容式磁场传感器

    公开(公告)号：US06765394B1

    公开(公告)日：2004-07-20

    申请号：US09868538

    申请日：2001-11-26

    申请人： Günter Igel ,  Ulrich Sieben ,  Jürgen Giehl

    发明人： Günter Igel ,  Ulrich Sieben ,  Jürgen Giehl

    IPC分类号： G01R2726

    CPC分类号： G01R33/038

    摘要： The invention relates to a capacitive magnetic field sensor. This sensor has a first electrode (2) and a second electrode (3), which are spaced apart from one another and which form a measurement capacitance. The first electrode (2) is situated on a first substrate body (4), and the second electrode (3) on a second substrate body (5). The second substrate body (5) is designed as a deformable membrane in the vicinity of the second electrode (3). A magnetic body (6) is situated in the vicinity of the second electrode (3) and the membrane, and is rigidly connected to the membrane and to the second electrode (3). As a result of this rigid connection, the influence of an external magnetic field on the magnetic body causes not only the magnetic body (6) to change its position but also causes the membrane and the second electrode (3) to change their position, since they are rigidly connected to said magnetic body. Because the second electrode (3) changes its position, its distance from the first electrode (2) changes, and thus the measurement capacitance, which acts as a measure of the externally applied magnetic field. This capacitive magnetic field sensor is distinguished by very small exterior dimensions, great mechanical stability, and low temperature dependence.

    摘要翻译： 本发明涉及电容式磁场传感器。 该传感器具有彼此间隔开并形成测量电容的第一电极（2）和第二电极（3）。 第一电极（2）位于第一基板主体（4）上，第二电极（3）位于第二基板主体（5）上。 第二基板体（5）被设计为在第二电极（3）附近的可变形膜。 磁体（6）位于第二电极（3）和膜附近，并且刚性地连接到膜和第二电极（3）。 作为这种刚性连接的结果，外部磁场对磁体的影响不仅使磁体（6）改变其位置，而且还使膜和第二电极（3）改变其位置，因为 它们刚性地连接到所述磁体。 因为第二电极（3）改变其位置，所以其与第一电极（2）的距离改变，因此测量电容用作外部施加的磁场的量度。 该电容式磁场传感器的外形尺寸非常小，机械稳定性好，温度依赖性低。

    Chip arrangement
    3.
    发明授权
    Chip arrangement 失效
    芯片布置

    公开(公告)号：US06288440B1

    公开(公告)日：2001-09-11

    申请号：US09342697

    申请日：1999-06-29

    申请人： Ulrich Sieben ,  Günter Igel ,  Mirko Lehmann ,  Hans-Jürgen Gahle ,  Bernhard Wolf ,  Werner Baumann ,  Ralf Ehret

    发明人： Ulrich Sieben ,  Günter Igel ,  Mirko Lehmann ,  Hans-Jürgen Gahle ,  Bernhard Wolf ,  Werner Baumann ,  Ralf Ehret

    IPC分类号： H01L23495

    CPC分类号： H01L23/5385 ,  A61B5/14532 ,  A61B5/1473 ,  G01N33/48707 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A chip arrangement (1) has a substrate board (2) with an opening (3), into which a carrier chip (4) is inserted, which has an electrical or electronic structural component (5). At least one conductor path (7) is integrated into the carrier chip (4), which connects the structural component (5) to the electrical connection contact (8). The carrier chip (4) is inserted into the opening (3) in such a way that its ends project beyond the opposite-facing, flat-sided surfaces (9, 9′) of the substrate board (2), and thereby form overhangs (10, 10′). Here, the structural component is arranged on the overhang (10) projecting beyond the one surface (9), and the connection contact (8) is arranged on the overhang (10′) projecting beyond the other surface (9′), and the conductor path (7) connecting the structural component (5) and the connection contact (8) passes through the opening (3). A seal is arranged between the substrate board (2) and the carrier chip (4).

    摘要翻译： 芯片装置（1）具有带有开口（3）的基板（2），其中插入有载体芯片（4），其具有电或电子结构部件（5）。 至少一个导体路径（7）集成到载体芯片（4）中，其将结构部件（5）连接到电连接触点（8）。 载体芯片（4）以这样的方式插入到开口（3）中，使得其端部突出超过衬底板（2）的相对面对的平坦表面（9,9'），从而形成突出部 （10,10'）。 这里，结构部件布置在突出超过一个表面（9）的伸出部（10）上，并且连接触点（8）布置在突出超过另一个表面（9'）的伸出部（10'）上，并且 连接结构部件（5）和连接触点（8）的导体路径（7）穿过开口（3）。 在基板（2）和载体芯片（4）之间设置密封件。

    Method for intracellular manipulation of a biological cell
    5.
    发明授权
    Method for intracellular manipulation of a biological cell 有权
    细胞内操作生物细胞的方法

    公开(公告)号：US06475760B1

    公开(公告)日：2002-11-05

    申请号：US09321051

    申请日：1999-05-27

    申请人： Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann ,  Günter Igel ,  Hans-Jürgen Gahle ,  Bernhard Wolf ,  Ulrich Sieben ,  Ingo Freund ,  Martin Brischwein

    发明人： Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann ,  Günter Igel ,  Hans-Jürgen Gahle ,  Bernhard Wolf ,  Ulrich Sieben ,  Ingo Freund ,  Martin Brischwein

    IPC分类号： C12N1300

    CPC分类号： C12N15/89 ,  C12M35/02 ,  C12M35/04 ,  C12M35/08 ,  C12N13/00

    摘要： A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.

    摘要翻译： 提供了一种用于细胞内操作生物细胞（3）的方法，所述生物细胞（3）定位为粘附在培养基（2）中的支持区域（5）。 在电池（3）的支撑区域（5）的内部，与电池（3）的隔膜形成的开口与其支撑边缘间隔开。 围绕开口的细胞膜的边缘附着在支撑区域（5）上，从而将位于细胞（3）内部的细胞液体与培养基（2）密封并使细胞液体抵抗培养物 中等（2）。 电池（3）的内部通过开口被操纵。 还提供了一种用于实现该方法的装置，包括具有用于粘附细胞的支撑区域（5）的物体载体（4）和用于在细胞膜中形成开口的引锭工具（6）。 引锭工具（6）可以是各种化学，机械和/或电气装置中的任何一种。

    Apparatus for intracellular manipulation of a biological cell
    7.
    发明授权
    Apparatus for intracellular manipulation of a biological cell 失效
    用于细胞内操作生物细胞的装置

    公开(公告)号：US07501276B2

    公开(公告)日：2009-03-10

    申请号：US10202419

    申请日：2002-07-23

    申请人： Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann ,  Günter Igel ,  Hans-Jürgen Gahle ,  Ulrich Sieben ,  Ingo Freund ,  Martin Brischwein

    发明人： Werner Baumann ,  Ralf Ehret ,  Mirko Lehmann ,  Günter Igel ,  Hans-Jürgen Gahle ,  Ulrich Sieben ,  Ingo Freund ,  Martin Brischwein

    IPC分类号： C12M1/42 ,  C12N15/87

    CPC分类号： C12N15/89 ,  C12M35/02 ,  C12M35/04 ,  C12M35/08 ,  C12N13/00

    摘要： A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.

    摘要翻译： 提供了一种用于细胞内操作生物细胞（3）的方法，所述生物细胞（3）定位为粘附在培养基（2）中的支持区域（5）。 在电池（3）的支撑区域（5）的内部，与电池（3）的隔膜形成的开口与其支撑边缘间隔开。 围绕开口的细胞膜的边缘附着在支撑区域（5）上，从而将位于细胞（3）内部的细胞液体与培养基（2）密封在一起，并使细胞液体抵抗培养物 中等（2）。 电池（3）的内部通过开口被操纵。 还提供了一种用于实现该方法的装置，包括具有用于粘附细胞的支撑区域（5）的物体载体（4）和用于在细胞膜中形成开口的引锭工具（6）。 引锭工具（6）可以是各种化学，机械和/或电气装置中的任何一种。

    Method for producing an optical transmitting and receiving device and a transmitting and receiving device produced according to said method
    8.
    发明授权
    Method for producing an optical transmitting and receiving device and a transmitting and receiving device produced according to said method 失效
    用于制造光发射和接收装置的方法和根据所述方法制造的发射和接收装置

    公开(公告)号：US06916673B2

    公开(公告)日：2005-07-12

    申请号：US10169008

    申请日：2000-12-19

    申请人： Ulrich Sieben ,  Günter Igel

    发明人： Ulrich Sieben ,  Günter Igel

    IPC分类号： H01L31/12 ,  H01L31/173 ,  H01L21/00

    CPC分类号： H01L31/173

    摘要： The invention relates to a method for producing an optical transmitting and receiving device (1, 1a) comprising a light emitting transmission element (3, 3a) and a receiving element (4, 4a) which converts this light into an electrical magnitude. The transmission and receiving elements are inserted into a silicon substrate. The optical transmitting and receiving device (1) is preferably inserted in a monolithic manner into a common substrate, comprising a sequence of superimposed layers for the light emitting transmission element (3) and the light receiving element (4). An electrically insulating intermediate layer (9, 9a) is incorporated between the transmission and receiving element.

    摘要翻译： 本发明涉及一种用于制造光发射和接收装置（1,1a）的方法，该光发射和接收装置（1,1a）包括发光透射元件（3,3a）和接收元件（4,4a），其将该光转换成电量 。 将传输和接收元件插入到硅衬底中。 光发送和接收装置（1）优选地以单片方式插入公共衬底中，包括用于发光透射元件（3）和光接收元件（4）的叠加层序列。 电绝缘中间层（9,9a）结合在传输和接收元件之间。

    Measuring device and method for making same
    9.
    发明授权
    Measuring device and method for making same 失效
    测量装置及其制作方法

    公开(公告)号：US06210977B1

    公开(公告)日：2001-04-03

    申请号：US09468449

    申请日：1999-12-21

    申请人： Ulrich Sieben ,  Bernhard Wolf ,  Hellmut Haberland ,  Christoph Cremer

    发明人： Ulrich Sieben ,  Bernhard Wolf ,  Hellmut Haberland ,  Christoph Cremer

    IPC分类号： G01N33543

    CPC分类号： G01N27/4145 ,  H01L2924/0002 ,  Y10S436/805 ,  H01L2924/00

    摘要： A measuring device for measuring or examining physiological parameters on biocomponents includes an FET sensor 5 whose electrical protective layer 12 is roughened or has a structured coating 15. The structuring of the active sensor contact surface 12 is adapted to the outer contour and topography of the biocomponent in question, so that a better possibility is available for anchoring the biocomponents to the contact surface 24 forming the FET protective layer of the sensor 5.

    摘要翻译： 用于测量或检查生物组件上的生理参数的测量装置包括FET传感器5，其电保护层12被粗糙化或具有结构化涂层15.主动传感器接触表面12的结构适用于生物组件的外轮廓和​​形貌 因此有可能将生物组分锚定到形成传感器5的FET保护层的接触表面24上。

    Device for treating malignant, tumorous tissue areas
    10.
    发明授权
    Device for treating malignant, tumorous tissue areas 失效
    用于治疗恶性肿瘤组织区域的装置

    公开(公告)号：US06245057B1

    公开(公告)日：2001-06-12

    申请号：US09425598

    申请日：1999-10-22

    申请人： Ulrich Sieben ,  Bernhard Wolf

    发明人： Ulrich Sieben ,  Bernhard Wolf

    IPC分类号： A61K922

    CPC分类号： A61B5/145 ,  A61B5/14539 ,  A61B5/1473 ,  A61M31/002

    摘要： A device (1) functions for treating malignant, tumorous tissue areas. The device has at least one measuring sensor for determining chemical or physical signal patterns in the immediate vicinity of the tumor cells or similar tissue part, a control unit and at least one treatment assembly, which has as an active agent release element for chemically influencing and/or treatment electrodes for physically influencing the tumorous tissue area to be treated. The sensor(s), the active agent release element, and the treatment electrodes are connected to the control unit for a physical and/or chemical treatment of the tumorous tissue area, controlled as a function of the measured values of the tumor cells. The device is constructed in the form of a swallowable capsule or dragée, and a sensor is provided for detecting release parameters. The control unit is designed with a threshold value switch for activating the active agent release element and/or the electrodes when a predetermined target value is exceeded.

    摘要翻译： 装置（1）用于治疗恶性肿瘤组织区域。 该装置具有至少一个用于确定肿瘤细胞或类似组织部分附近的化学或物理信号图案的测量传感器，控制单元和至少一个处理组件，其具有用于化学影响的活性剂释放元件和 /或用于物理影响待治疗的肿瘤组织区域的治疗电极。 传感器，活性剂释放元件和处理电极连接到控制单元，用于根据肿瘤细胞的测量值来控制肿瘤组织区域的物理和/或化学处理。 该装置以吞咽胶囊或拖把的形式构造，并且提供用于检测释放参数的传感器。 当超过预定目标值时，控制单元设计有用于激活活性剂释放元件和/或电极的阈值开关。