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公开(公告)号：US10316084B2
公开(公告)日：2019-06-11
申请号：US15363045
申请日：2016-11-29
Applicant: GENENTECH, INC.
Inventor： Andrew G. Polson , Weiguang Mao , Ron Firestein
IPC: C07K16/28 , C07K16/30 , G01N33/574 , G01N33/58 , A61K39/395 , A61K39/00
Abstract: The invention provides anti-LgR5 antibodies and methods of using the same.
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公开(公告)号：US20160368994A1
公开(公告)日：2016-12-22
申请号：US15182327
申请日：2016-06-14
Applicant: Genentech, Inc.
Inventor： Robert F. Kelley , Steven R. Leong , Wei-Ching Liang , Mary Mathieu , Andrew G. Polson , Bing Zheng , Xiaocheng Chen , Cecilia Pui Chi Chiu , Mark S. Dennis , Allen Ebens , Yan Wu
IPC: C07K16/28 , A61K45/06 , A61K39/395
CPC classification number: C07K16/2851 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/57 , C07K16/2803 , C07K16/2809 , C07K16/2827 , C07K16/3061 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g., anti-CLL-1/CD3 T cell dependent bispecific (TDB) antibody) and methods of using the same.
Abstract translation: 本发明涉及包含CLL-1结合结构域和CD3结合结构域（例如，抗CLL-1 / CD3T细胞依赖性双特异性（TDB）抗体）的抗CLL-1抗体的抗CLL-1抗体， 使用方法
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公开(公告)号：US20200222545A1
公开(公告)日：2020-07-16
申请号：US16827083
申请日：2020-03-23
Applicant: Genentech, Inc.
Inventor： Thomas Pillow , Andrew G. Polson , Bing Zheng
IPC: A61K47/54 , C07K19/00 , C07D407/12 , A61K45/06 , A61K47/68 , A61K31/357 , G01N33/567
Abstract: The invention relates generally to a silvestrol molecule activated with a leaving group. The invention further relates generally to an antibody-drug conjugate comprising an antibody conjugated by a linker to one or more silvestrol drug moieties and methods of treatment.
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公开(公告)号：US20170233471A1
公开(公告)日：2017-08-17
申请号：US15363045
申请日：2016-11-29
Applicant: GENENTECH, INC.
Inventor： Andrew G. Polson , Weiguang Mao , Ron Firestein
IPC: C07K16/28 , G01N33/574
CPC classification number: C07K16/28 , C07K16/3046 , C07K2317/56 , C07K2317/565 , C07K2317/70 , G01N33/57492 , G01N2800/52
Abstract: The invention provides anti-LgR5 antibodies and methods of using the same.
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公开(公告)号：US11352431B2
公开(公告)日：2022-06-07
申请号：US16583584
申请日：2019-09-26
Applicant: Genentech, Inc.
Inventor： Allen J. Ebens , Meredith C. Hazen , Jo-Anne Hongo , Jennifer W. Johnston , Teemu T. Junttila , Ji Li , Andrew G. Polson
IPC: C07H21/04 , C07H21/02 , C12P21/06 , C12P21/04 , C12N5/02 , C12N5/16 , C07K16/28 , A61K47/68 , A61K39/395 , A61K51/10 , C07K16/00 , A61K39/00
Abstract: The invention provides anti-FcRH5 antibodies and immunoconjugates and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20170348422A1
公开(公告)日：2017-12-07
申请号：US15613477
申请日：2017-06-05
Applicant: Genentech, Inc.
Inventor： Thomas Pillow , Andrew G. Polson , Bing Zheng
IPC: A61K47/54 , A61K31/357 , G01N33/567 , A61K39/00
CPC classification number: A61K47/541 , A61K31/357 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K47/6855 , A61K2039/572 , A61K2039/627 , C07D407/12 , C07K19/00 , G01N33/567
Abstract: The invention relates generally to a silvestrol molecule activated with a leaving group. The invention further relates generally to an antibody-drug conjugate comprising an antibody conjugated by a linker to one or more silvestrol drug moieties and methods of treatment.
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公开(公告)号：US20150098900A1
公开(公告)日：2015-04-09
申请号：US14313822
申请日：2014-06-24
Applicant: Genentech, Inc.
Inventor： Allen J. Ebens , Meredith C. Hazen , Jo-Anne Hongo , Jennifer W. Johnston , Teemu T. Junttila , Ji Li , Andrew G. Polson
IPC: C07K16/28 , A61K39/395 , A61K51/10 , A61K47/48
CPC classification number: C07K16/283 , A61K39/395 , A61K39/3955 , A61K47/6803 , A61K47/6849 , A61K47/6879 , A61K47/6889 , A61K51/1045 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/33 , C07K2317/56
Abstract: The invention provides anti-FcRH5 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗FcRH5抗体和免疫缀合物及其使用方法。
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公开(公告)号：US11648315B2
公开(公告)日：2023-05-16
申请号：US16827083
申请日：2020-03-23
Applicant: Genentech, Inc.
Inventor： Thomas Pillow , Andrew G. Polson , Bing Zheng
IPC: A61K31/357 , A61K45/06 , C07D407/12 , C07K19/00 , G01N33/567 , A61K47/54 , A61K47/68 , A61K39/00
CPC classification number: A61K47/541 , A61K31/357 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K47/6855 , C07D407/12 , C07K19/00 , G01N33/567 , A61K2039/572 , A61K2039/627
Abstract: The invention relates generally to a silvestrol molecule activated with a leaving group. The invention further relates generally to an antibody-drug conjugate comprising an antibody conjugated by a linker to one or more silvestrol drug moieties and methods of treatment.
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公开(公告)号：US11466087B2
公开(公告)日：2022-10-11
申请号：US16658706
申请日：2019-10-21
Applicant: Genentech, Inc.
Inventor： Robert F. Kelley , Steven R. Leong , Wei-Ching Liang , Mary Mathieu , Andrew G. Polson , Bing Zheng , Xiaocheng Chen , Cecilia Pui Chi Chiu , Mark S. Dennis , Allen Ebens , Yan Wu
IPC: A61K39/395 , C07K16/28 , C07K16/30 , A61K45/06 , A61K39/00
Abstract: The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g., anti-CLL-1/CD3 T cell dependent bispecific (TDB) antibody) and methods of using the same.
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公开(公告)号：US20200148774A1
公开(公告)日：2020-05-14
申请号：US16658706
申请日：2019-10-21
Applicant: Genentech, Inc.
Inventor： Robert F. Kelley , Steven R. Leong , Wei-Ching Liang , Mary Mathieu , Andrew G. Polson , Bing Zheng , Xiaocheng Chen , Cecilia Pui Chi Chiu , Mark S. Dennis , Allen Ebens , Yan Wu
IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06
Abstract: The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g., anti-CLL-1/CD3 T cell dependent bispecific (TDB) antibody) and methods of using the same.
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