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    Chewing Gum Containing Physiological Cooling Agents
    4.
    发明申请
    Chewing Gum Containing Physiological Cooling Agents 审中-公开
    含有生理冷却剂的口香糖

    公开(公告)号：US20080199565A1

    公开(公告)日：2008-08-21

    申请号：US12111635

    申请日：2008-04-29

    申请人： Fred R. Wolf ,  Gordon N. McGrew ,  Jeffrey S. Hook ,  Lindell C. Richey ,  Mansukh M. Patel ,  Robert J. Yatka ,  David L. Witkewitz ,  Michael J. Greenberg ,  Henry T. Tyrpin ,  Kathryn T. Nelson

    发明人： Fred R. Wolf ,  Gordon N. McGrew ,  Jeffrey S. Hook ,  Lindell C. Richey ,  Mansukh M. Patel ,  Robert J. Yatka ,  David L. Witkewitz ,  Michael J. Greenberg ,  Henry T. Tyrpin ,  Kathryn T. Nelson

    IPC分类号： A23G4/06 ,  A23G4/20

    CPC分类号： A23G4/06 ,  A23G4/062 ,  A23G4/068 ,  A23G4/20 ,  A23G2200/00

    摘要： A method for producing a chewing gum, as well as the chewing gum so produced, incorporates a physiological cooling agent, such as acyclic carboxamide, or combinations of physiological cooling agents. In another embodiment a combination of physiological cooling agents is made in a modified release structure. The modified release/cooling agents combination is preferably obtained by physically modifying the properties of the combination of cooling agents by coating and drying. When incorporated into gum, these particles are adapted to enhance the shelf stability of the flavor and/or produce a modified release when the gum is chewed. In another embodiment, the physiological cooling agent is present with menthol and menthone.In another embodiment, coated chewing gum has a coating that comprises a physiological cooling agent. The preferred inventive chewing gum provides a high flavor impact in which the harsh notes normally associated with such a high flavor impact have been reduced or eliminated. In addition, the preferred inventive gum provides a clean, high-quality, cooling chewing gum coating with xylitol or other polyols where xylitol has been reduced in concentration or eliminated.

    摘要翻译： 用于生产口香糖的方法以及如此制备的口香糖包含生理冷却剂，例如无环羧酰胺，或生理冷却剂的组合。 在另一个实施方案中，将生理冷却剂的组合制成改性释放结构。 改性释放/冷却剂组合优选通过涂覆和干燥来物理改变冷却剂组合的性质来获得。 当掺入胶中时，这些颗粒适于增强风味剂的贮存稳定性和/或当咀嚼口香糖时产生改性释放物。 在另一个实施方案中，生理冷却剂存在薄荷醇和薄荷酮。 在另一个实施方案中，涂覆的口香糖具有包含生理冷却剂的涂层。 优选的本发明的口香糖提供高风味影响，其中通常与如此高的风味影响相关联的刺耳味通常已被减少或消除。 此外，优选的本发明的胶提供了具有木糖醇或其它多元醇的清洁，高质量的冷却口香糖涂料，其中木糖醇已经被浓缩或被消除。

    Method of controlling release of bitterness inhibitors in chewing gum and gum produced thereby
    6.
    发明授权
    Method of controlling release of bitterness inhibitors in chewing gum and gum produced thereby 有权
    控制由此产生的口香糖和口香糖中苦味抑制剂释放的方法

    公开(公告)号：US06472000B1

    公开(公告)日：2002-10-29

    申请号：US09319054

    申请日：1999-05-26

    申请人： Victor V. Gudas ,  Michael A. Reed ,  Philip G. Schnell ,  Henry T. Tyrpin ,  David L. Witkewitz ,  Michael J. Greenberg ,  Fred R. Wolf

    发明人： Victor V. Gudas ,  Michael A. Reed ,  Philip G. Schnell ,  Henry T. Tyrpin ,  David L. Witkewitz ,  Michael J. Greenberg ,  Fred R. Wolf

    IPC分类号： A23G330

    CPC分类号： A23G4/06 ,  A23G4/20 ,  A23L27/72 ,  A23L27/86 ,  A61K9/0058

    摘要： A method for producing a chewing gum with a controlled release of a bitterness inhibitor, as well as the chewing gum so produced, is obtained by physically modifying the release properties of the bitterness inhibitor by coating and drying. The bitterness inhibitor is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated bitterness inhibitor is preferably then co-dried and particle sized to produce a release-modified bitterness inhibitor for use in chewing gum. When incorporated into the chewing gum, these particles are adapted to produce a fast release or a delayed release when the gum is chewed. The preferred bitterness inhibitor is sodium gluconate.

    摘要翻译： 通过涂布和干燥来物理改变苦味抑制剂的释放性能，可获得生产具有控制释放苦味抑制剂的口香糖的方法，以及所生产的口香糖。 苦味抑制剂通过包封进行包衣，通过附聚部分包衣，通过吸收包埋，或通过包封，附聚和吸收的多个步骤进行处理。 涂覆的苦味抑制剂优选然后被共干燥并且颗粒大小以产生用于口香糖的释放改性苦味抑制剂。 当掺入口香糖中时，当咀嚼口香糖时，这些颗粒适于产生快速释放或延迟释放。 优选的苦味抑制剂是葡萄糖酸钠。

    Pharmaceutical chewing gum formulations
    8.
    发明授权
    Pharmaceutical chewing gum formulations 有权
    制药口香糖配方

    公开(公告)号：US07078052B2

    公开(公告)日：2006-07-18

    申请号：US10743609

    申请日：2003-12-22

    申请人： Ronald L. Ream ,  Christine L. Corriveau ,  William J. Wokas ,  Thomas M. Tongue, Jr. ,  Michael J. Greenberg

    发明人： Ronald L. Ream ,  Christine L. Corriveau ,  William J. Wokas ,  Thomas M. Tongue, Jr. ,  Michael J. Greenberg

    IPC分类号： A61K9/68

    CPC分类号： A61K9/209 ,  A23G3/343 ,  A23G4/08 ,  A23G4/20 ,  A23G2200/04 ,  A61K9/0058

    摘要： Methods and chewing gums for delivering a medicament or agent to an individual are provided. The chewing gum includes a medicament or agent. The medicament or agent is present within the chewing gum composition (the water soluble portion and/or insoluble base portion). It has been found that by chewing the gum, the medicament or agent is released from the chewing gum. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.

    摘要翻译： 提供了用于将药物或药剂递送给个体的方法和口香糖。 口香糖包括药物或药剂。 药物或药剂存在于口香糖组合物（水溶性部分和/或不溶性基底部分）内。 已经发现，通过咀嚼牙龈，药物或药剂从口香糖中释放出来。 继续咀嚼口香糖在口腔内产生压力，通过包含在口腔中的口腔粘膜，迫使药剂或药物直接进入个体的系统系统。 这大大增强了药物在系统系统中的吸收以及药物在系统内的生物利用度。

    Method of controlling release of N-substituted derivatives of aspartame in chewing gum
    10.
    发明授权
    Method of controlling release of N-substituted derivatives of aspartame in chewing gum 有权
    控制口香糖中阿斯巴甜的N-取代衍生物释放的方法

    公开(公告)号：US06692778B2

    公开(公告)日：2004-02-17

    申请号：US09731036

    申请日：2000-12-05

    申请人： Robert J. Yatka ,  Donald J. Townsend ,  Sonya S. Johnson ,  Michael J. Greenberg ,  Daniel J. Sitler

    发明人： Robert J. Yatka ,  Donald J. Townsend ,  Sonya S. Johnson ,  Michael J. Greenberg ,  Daniel J. Sitler

    IPC分类号： A23G330

    CPC分类号： A23G4/14 ,  A23G4/06 ,  A23G4/08 ,  A23G4/20 ,  A23L27/32 ,  A23L27/70 ,  A23V2002/00 ,  A23V2250/2484 ,  A23V2250/24 ,  A23V2250/51082 ,  A23V2250/6408 ,  A23V2250/5028 ,  A23V2250/51086 ,  A23V2250/5114 ,  A23V2250/2482 ,  A23V2200/224

    摘要： The present invention includes a method for producing a chewing gum with a modified release sweetener selected from the group of N-substituted derivatives of aspartame, particularly neotame, as well as the chewing gum so produced. The modified release neotame or other N-substituted derivative of aspartame sweetener is obtained by physically modifying the sweetener properties by coating and drying. Neotame or another N-substituted derivative of aspartame sweetener is coated by encapsulation, partially coated by agglomeration, entrapped by absorption or extrusion, or treated by multiple steps of encapsulation, agglomeration, absorption, or extrusion. The coated sweetener is then co-dried and particle sized to produce a release-modified high-intensity sweetener. When incorporated into the chewing gum, these particles are adapted to enhance the shelf stability of the sweetener and/or produce a modified release when the gum is chewed.

    摘要翻译： 本发明包括一种用改性释放甜味剂生产口香糖的方法，该改性释放甜味剂选自阿斯巴甜的N-取代衍生物，特别是neotame，以及所生产的口香糖。 通过涂布和干燥物理改性甜味剂性质，得到阿斯巴甜甜味剂的改性释放纽甜或其它N-取代衍生物。 Neotame或天冬甜素甜味剂的另一N-取代衍生物通过包封进行包衣，通过附聚部分包衣，通过吸收或挤出包埋，或通过包封，附聚，吸收或挤出的多个步骤进行处理。 然后将涂覆的甜味剂共干燥并调整颗粒大小以产生释放改性的高强度甜味剂。 当掺合到口香糖中时，这些颗粒适于增强甜味剂的贮存稳定性和/或当咀嚼口香糖时产生改性释放物。