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    Radiation-curable prepolymers
    2.
    发明申请
    Radiation-curable prepolymers 有权

    公开(公告)号：US20060030679A1

    公开(公告)日：2006-02-09

    申请号：US11243928

    申请日：2005-10-05

    申请人： John Phelan ,  Michael Quinn ,  Joshua Wallach

    发明人： John Phelan ,  Michael Quinn ,  Joshua Wallach

    IPC分类号： C08G18/00

    CPC分类号： C08G18/672 ,  C08G18/678 ,  G02B1/043 ,  C08L75/04 ,  C08G18/6677

    摘要： The present invention provides a radiation-curable prepolymer. The radiation-curable prepolymer of the invention is prepared by reacting an isocyanate-capped polyurethane with an ethylenically unsaturated amine or an ethylenically unsaturated monohydroxy compound or a mixture thereof, wherein the isocyanate-capped polyurethane is a copolymerization production of: (a) at least one polyalkylene glycol; (b) at least one branching agent having at least three hydroxy groups; and (c) at least one di- or polyisocyanate. The radiation-curable prepolymer of the invention can find use in economically producing contact lenses which have durable, highly elastic soft contact lenses with desired physical properties. In addition, the present invention provides method for making a radiation-curable prepolymer of the invention and for making a medical device, preferably an ophthalmic device, more preferably a contact lens.

    Colored ink for pad transfer printing of silicone hydrogel lenses
    3.
    发明申请
    Colored ink for pad transfer printing of silicone hydrogel lenses 有权
    彩色墨水用于硅胶水凝胶镜片的转印印刷

    公开(公告)号：US20050218536A1

    公开(公告)日：2005-10-06

    申请号：US11093819

    申请日：2005-03-30

    申请人： Michael Quinn ,  Gregory Carlson ,  Barry Atkins

    发明人： Michael Quinn ,  Gregory Carlson ,  Barry Atkins

    IPC分类号： B29D11/00 ,  C09D11/00 ,  C09D11/10 ,  G02B1/04 ,  G02C7/04

    CPC分类号： G02B1/10 ,  B29C41/003 ,  B29D11/00048 ,  B29D11/00317 ,  B29K2083/005 ,  B29K2105/0014 ,  B29K2105/0032 ,  B29K2105/0061 ,  B29L2009/00 ,  B29L2011/0041 ,  C09D11/107 ,  G02B1/043 ,  C08L83/04

    摘要： The present invention provides a method for making colored silicone hydrogel contact lenses. The method of the invention comprises the steps of: (a) applying a color coat to at least a portion of at least one of molding surfaces of a lens mold with an ink, wherein the ink comprises at least one colorant, a binder polymer, an adhesion promoter, and optionally a diluent, wherein the binder polymer is a copolymerization product of a polymerizable mixture including (i) at least one hydrophilic vinylic monomer; (ii) at least one functionalizing vinylic monomer containing at least one functional group selected from the group consisting of hydroxyl group —OH, amino group —NHR (wherein R is hydrogen or C1 to C8 alkyl), carboxylic group —COOH, epoxy group, amide group —CONHR, and combinations thereof; (iii) at least one silicone-containing vinylic monomer or macromer, and (iv) optionally one or more components selected from the group consisting of a polymerization initiator, a chain transfer agent, and a solvent, wherein the mold has a lens-forming cavity between the molding surfaces, wherein the colored coat contains a first surface exposed to the interior of the lens-forming cavity and a second surface in contact with the molding surface; (b) curing the ink printed on the mold; (c) dispensing a silicone hydrogel lens-forming material into the lens-forming cavity of the mold; (d) curing the lens-forming material within the lens-forming cavity to form the contact lens, whereby the colored coat detaches from the molding surface and becomes integral with the body of the contact lens.

    摘要翻译： 本发明提供一种制备有色硅酮水凝胶隐形眼镜的方法。 本发明的方法包括以下步骤：（a）将彩色涂层施加到具有油墨的透镜模具的至少一个模制表面的至少一部分上，其中所述油墨包括至少一种着色剂，粘合剂聚合物， 粘合促进剂和任选的稀释剂，其中粘合剂聚合物是可聚合混合物的共聚产物，其包含（i）至少一种亲水性乙烯基单体; （ii）至少一种官能化乙烯基单体，其含有至少一个选自羟基-OH，氨基-NHR（其中R是氢或C 1至C 1至C 1）的官能团， 烷基），羧基-COOH，环氧基，酰胺基-CONHR及其组合; （iii）至少一种含硅酮的乙烯基单体或大分子单体，和（iv）任选的一种或多种选自聚合引发剂，链转移剂和溶剂的组分，其中模具具有透镜形成 模制表面之间的空腔，其中着色涂层包含暴露于透镜形成腔的内部的第一表面和与模制表面接触的第二表面; （b）固化印在模具上的油墨; （c）将硅酮水凝胶透镜形成材料分配到模具的透镜形成腔中; （d）固化透镜形成腔内的透镜形成材料以形成隐形眼镜，由此着色涂层从模制表面脱离并与隐形眼镜的主体成一体。

    End of Injection Indicator for Injection Pen
    6.
    发明申请
    End of Injection Indicator for Injection Pen 有权
    注射笔注射指示器结束

    公开(公告)号：US20140163477A1

    公开(公告)日：2014-06-12

    申请号：US14005603

    申请日：2012-03-16

    申请人： Michael Quinn ,  Richard Cronenberg ,  Gautam Shetty

    发明人： Michael Quinn ,  Richard Cronenberg ,  Gautam Shetty

    IPC分类号： A61M5/315

    CPC分类号： A61M5/31533 ,  A61M5/31551 ,  A61M5/3157 ,  A61M5/31585 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/583

    摘要： A medication injection pen (50) includes a housing (1) and a dose set knob (2) rotatably connected to the housing (1) for setting a dose. An indicator member (200) is movable between an visible position indicating a zero position of the dose set knob (2) and a non-visible position indicating a non-zero position of the dose set knob (2). The indicator member is visible to a user in the visible position and not visible in the non-visible position. The dose set knob is in the zero position when a set dose has been completely administered. Accordingly, a visible indication is provided to a user when a set dose has been completely administered.

    摘要翻译： 药物注射笔（50）包括可旋转地连接到壳体（1）的用于设定剂量的壳体（1）和剂量设定旋钮（2）。 指示器构件（200）可在指示剂量设定旋钮（2）的零位置的可见位置和指示剂量设定旋钮（2）的非零位置的不可见位置之间移动。 指示器构件对于可见位置的用户可见，并且在不可见位置中不可见。 当设定的剂量已经完全施用时，剂量设定旋钮处于零位置。 因此，当已经完全施用设定剂量时，向使用者提供可视指示。

    INJECTION PEN WITH DIAL BACK AND LAST DOSE CONTROL
    7.
    发明申请
    INJECTION PEN WITH DIAL BACK AND LAST DOSE CONTROL 有权
    注射笔与拨号和最后的剂量控制

    公开(公告)号：US20120283647A1

    公开(公告)日：2012-11-08

    申请号：US13261300

    申请日：2010-11-30

    申请人： Richard Cronenberg ,  Michael Quinn ,  Haiming Wu

    发明人： Richard Cronenberg ,  Michael Quinn ,  Haiming Wu

    IPC分类号： A61M5/31

    CPC分类号： A61M5/31548 ,  A61M5/24 ,  A61M5/2466 ,  A61M5/31535 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31551 ,  A61M5/3156 ,  A61M5/31563 ,  A61M5/3157 ,  A61M5/31573 ,  A61M5/31575 ,  A61M5/31585 ,  A61M5/31595 ,  A61M5/3202 ,  A61M5/347 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/2492 ,  A61M2205/581

    摘要： A medication injection pen is provided comprising a housing (218), for housing a dose set knob (220), a leadscrew (226), a driver (224), a setback member (222), and a dose stop member (228). The dose set knob (220) is rotatable with respect to said housing (218) to set a desired injection dose, and comprises at least one internal thread (291). The leadscrew (226) includes a thread element by which it is advanceable in a first direction via a corresponding thread engagement, said first direction being that which expels medication from a cartridge (36). The driver (224) is rotationally fixed to said leadscrew (226) for preventing relative rotation therebetween, said driver (224) being rotatable in a first direction to rotate and advance said leadscrew (226) in said first direction. The setback member (222) is rotationally fixed to said driver (224) for preventing relative rotation therebetween.

    摘要翻译： 提供了一种药物注射笔，其包括用于容纳剂量设定旋钮（220），丝杠（226），驱动器（224），挫折部件（222）和剂量停止部件（228）的壳体（218） 。 剂量设定旋钮（220）可相对于所述壳体（218）旋转以设定期望的喷射剂量，并且包括至少一个内螺纹（291）。 丝杠（226）包括螺纹元件，通过该螺纹元件可以通过相应的螺纹接合在第一方向前进，所述第一方向是从药筒（36）排出药物的螺纹元件。 驱动器（224）旋转地固定到所述丝杠（226）上以防止它们之间的相对旋转，所述驱动器（224）可沿第一方向旋转并使所述丝杠（226）沿所述第一方向前进。 遏制构件（222）旋转地固定到所述驱动器（224），以防止它们之间的相对旋转。

    Depletion of plasma proteins
    8.
    发明申请
    Depletion of plasma proteins 审中-公开
    消耗血浆蛋白

    公开(公告)号：US20090035849A1

    公开(公告)日：2009-02-05

    申请号：US11983203

    申请日：2007-11-06

    申请人： Gregory E. Rice ,  Mark S. Baker ,  Michael Quinn

    发明人： Gregory E. Rice ,  Mark S. Baker ,  Michael Quinn

    IPC分类号： C12M1/00 ,  C07K1/00 ,  C07K16/18

    CPC分类号： G01N30/14 ,  C07K1/22 ,  G01N33/6854 ,  G01N2030/009 ,  B01D15/3804

    摘要： This invention relates to methods of analysis, and in particular to methods for the preliminary fractionation of samples in which low abundance molecules of interest, for example proteins, polysaccharides or fatty acids, are present together with more abundant molecules of little or no interest. In particular, the invention relates to methods of depletion of high abundance proteins from biological samples. Products and kits for use in the method are also disclosed, and form part of the invention.In one aspect, the invention provides a method of depleting a high-abundance molecule from a biological sample, comprising the steps of a) subjecting the sample to affinity depletion using an affinity support with high affinity for a high abundance molecule, and/or b) immunodepletion using an affinity support coupled to an antibody directed against whole or previously fractionated plasma or serum.

    摘要翻译： 本发明涉及分析方法，特别涉及用于初步分级分离样品的方法，其中存在低丰度的目标分子，例如蛋白质，多糖或脂肪酸，以及更多丰富的很少或不感兴趣的分子。 特别地，本发明涉及从生物样品中消耗高丰度蛋白质的方法。 还公开了用于该方法的产品和试剂盒，并且构成了本发明的一部分。 一方面，本发明提供了从生物样品中消耗高丰度分子的方法，包括以下步骤：a）使用对高丰度分子具有高亲和力的亲和载体使样品亲和耗尽，和/或b ）使用与针对全部或先前分级的血浆或血清的抗体偶联的亲和载体的免疫缺损。

    TOILET OVERFLOW CONTROL
    9.
    发明申请
    TOILET OVERFLOW CONTROL 审中-公开
    厕所溢流控制

    公开(公告)号：US20090000018A1

    公开(公告)日：2009-01-01

    申请号：US11747592

    申请日：2007-05-11

    申请人： Michael Quinn

    发明人： Michael Quinn

    IPC分类号： E03D11/02

    CPC分类号： E03D11/00 ,  E03D11/02 ,  Y02A10/34

    摘要： A toilet overflow control system is provided including a secondary float chamber and secondary float. The secondary float chamber is located below the toilet water tank and behind the toilet bowl at the water level of the toilet bowl and extending upward to the bottom of the toilet water tank. A vertical rod extends upward from the secondary float and is attached to a lever on the toilet water supply valve. This allows the secondary float to turn off the water when the toilet bowl water rises above a normal level. The vertical rod is inside a tube that allows it to go through the water tank without any loss of water. The secondary float chamber is fluidically connected to the toilet bowl by a horizontal conduit located just above the toilet bowl normal water level. A rinse hose is connected to the water supply valve to allow rinse water to flow into the secondary float chamber to prevent a back flow of water into the secondary float chamber during the flush.

    摘要翻译： 提供一种马桶溢流控制系统，包括一个副浮球室和二次浮球。 二次浮球室位于马桶水箱下方，并在马桶的水位下方的马桶盆后方，并向上延伸到马桶水箱的底部。 垂直杆从次级浮子向上延伸并连接到马桶供水阀上的杆上。 这使得当马桶水升高到正常水平以上时，辅助浮球可以关闭水。 垂直杆在管内，允许其通过水箱而没有任何水分损失。 二次浮子室通过位于马桶正常水位正上方的水平导管流体连接到马桶。 冲洗软管连接到供水阀，以允许冲洗水流入辅助浮球室，以防止在冲洗过程中水进入次浮球室。