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公开(公告)号：US20160081696A1
公开(公告)日：2016-03-24
申请号：US14862043
申请日：2015-09-22
申请人： Gregory T. Zugates , Joseph Lomakin , Jennifer Mortenson , Jeffrey Groom II , John Marini , Stephanie Webber
发明人： Gregory T. Zugates , Joseph Lomakin , Jennifer Mortenson , Jeffrey Groom II , John Marini , Stephanie Webber
CPC分类号： A61B17/12186 , A61B17/0057 , A61B17/12181 , A61B17/12195 , A61B2017/00495 , A61B2017/00646 , A61B2017/1205 , A61M5/31596 , A61M25/0026
摘要： In various aspects, present disclosure is directed to methods, devices and systems whereby one or more low viscosity fluids may be introduced into a catheter and whereby the one or more low viscosity fluids may be converted into a high viscosity fluid in the catheter, which high viscosity fluid may be delivered from an exit port of the catheter.
摘要翻译： 在各方面，本公开涉及一种方法，装置和系统，其中一种或多种低粘度流体可以被引入导管中，并且由此一种或多种低粘度流体可以在导管中转化为高粘度流体，其高 粘度流体可以从导管的出口输送。
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公开(公告)号：US20160051264A1
公开(公告)日：2016-02-25
申请号：US14728393
申请日：2015-06-02
申请人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译： 公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。 这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。 当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。
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公开(公告)号：US20160256170A1
公开(公告)日：2016-09-08
申请号：US14212930
申请日：2014-03-14
申请人： Rany Busold , John Marini , Upma Sharma , Adam Rago , Jennifer Mortensen , Joseph Lomakin , Gregory T. Zugates , Janet Komatsu
发明人： Rany Busold , John Marini , Upma Sharma , Adam Rago , Jennifer Mortensen , Joseph Lomakin , Gregory T. Zugates , Janet Komatsu
CPC分类号： A61B17/12118 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/1205 , A61B2217/005 , A61F2/07 , A61F2/95 , A61F2002/077 , A61M25/0067 , A61M25/007 , A61M25/0074 , A61M25/10 , A61M25/1006 , A61M2025/0004 , A61M2025/0078 , A61M2025/0175
摘要： Systems and method for treating aneurysms are provided which utilize formulations that form polymer foams in situ. The formulations generally have a buoyancy greater than or less than blood, and either float to the top of the aneurysm and foam from the top down or sink to the bottom and foam from the bottom up.
摘要翻译： 提供了用于治疗动脉瘤的系统和方法，其利用原位形成聚合物泡沫的制剂。 制剂通常具有大于或小于血液的浮力，并且浮动到动脉瘤的顶部并且从顶部向下或从底部向下沉入泡沫，并且从下向上浮起泡沫。
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公开(公告)号：US20130317418A1
公开(公告)日：2013-11-28
申请号：US13815910
申请日：2013-03-15
申请人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
IPC分类号： A61M37/00
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译： 公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。 这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。 当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。
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公开(公告)号：US20140322512A1
公开(公告)日：2014-10-30
申请号：US14211742
申请日：2014-03-14
申请人： Quynh Pham , Xuri Ray Yan , Abby Deleault , Toby Freyman , Joseph Lomakin , Gregory T. Zugates
发明人： Quynh Pham , Xuri Ray Yan , Abby Deleault , Toby Freyman , Joseph Lomakin , Gregory T. Zugates
CPC分类号： D01F8/16 , D01D5/0007 , D01F1/103 , D04H3/005 , Y10T428/2929 , Y10T442/186
摘要： According to one aspect of the invention, multicomponent fiber are provided, which comprise (a) a polymeric core that comprises a core-forming polymer and (b) a polymeric sheath that comprises a sheath-forming polymer that is different than the core-forming polymer. Examples of core-forming polymers include, for instance, crosslinked polysiloxanes and thermoplastic polymers, among others. Examples of sheath-forming polymers include, for instance, solvent-soluble polymers, degradable polymers and hydrogel-forming polymers, among others. Other aspects of the present invention pertain to methods of forming such multicomponent fibers. For example, in certain preferred embodiments, the multicomponent fibers are formed using coaxial electrospinning techniques. Still other aspects of the present invention pertain to meshes and other articles that are formed using the multicomponent fibers.
摘要翻译： 根据本发明的一个方面，提供了多组分纤维，其包括（a）包含芯形成聚合物的聚合物芯，和（b）聚合物护套，其包含与形成芯的聚合物不同的鞘形聚合物 聚合物。 成核聚合物的实例包括例如交联聚硅氧烷和热塑性聚合物等。 鞘形成聚合物的实例包括例如溶剂可溶性聚合物，可降解聚合物和形成水凝胶的聚合物等。 本发明的其它方面涉及形成这种多组分纤维的方法。 例如，在某些优选实施例中，使用同轴静电纺丝技术形成多组分纤维。 本发明的其它方面涉及使用多组分纤维形成的网格和其它制品。
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公开(公告)号：US09522215B2
公开(公告)日：2016-12-20
申请号：US14455117
申请日：2014-08-08
申请人： Adam Rago , John Marini , Gregory T. Zugates , Marc Helmick , Upma Sharma
发明人： Adam Rago , John Marini , Gregory T. Zugates , Marc Helmick , Upma Sharma
CPC分类号： A61L24/046 , A61L24/0036 , A61L2400/04 , C08L75/04
摘要： Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.
摘要翻译： 提供了用于治疗腔内出血的系统，方法和试剂盒。 该方法利用对封闭空腔施加快速的压力尖峰，然后采用稳态压力或压力。
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公开(公告)号：US20150223819A1
公开(公告)日：2015-08-13
申请号：US14597993
申请日：2015-01-15
申请人： Adam Rago , John Marini , Gregory T. Zugates , Marc Helmick , Marc Helmick , Upma Sharma
发明人： Adam Rago , John Marini , Gregory T. Zugates , Marc Helmick , Marc Helmick , Upma Sharma
IPC分类号： A61B17/12
CPC分类号： A61B17/12 , A61B2017/12004 , A61L24/0036 , A61L24/046 , A61L2400/04 , A61M13/003 , A61M2205/3341 , A61M2205/3344 , A61M2210/1021 , A61M2210/12 , C08L75/04
摘要： Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.
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公开(公告)号：US20150012031A1
公开(公告)日：2015-01-08
申请号：US14455117
申请日：2014-08-08
申请人： Adam RAGO , John Marini , Gregory T. Zugates , Marc Helmick , Upma Sharma
发明人： Adam RAGO , John Marini , Gregory T. Zugates , Marc Helmick , Upma Sharma
CPC分类号： A61L24/046 , A61L24/0036 , A61L2400/04 , C08L75/04
摘要： Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.
摘要翻译： 提供了用于治疗腔内出血的系统，方法和试剂盒。 该方法利用对封闭空腔施加快速的压力尖峰，然后采用稳态压力或压力。
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公开(公告)号：US20160128850A1
公开(公告)日：2016-05-12
申请号：US15000605
申请日：2016-01-19
申请人： Maria Palasis , Changcheng You , Danny Concagh , Lee Core , Kicherl Ho , Upma Sharma , Gregory T. Zugates
发明人： Maria Palasis , Changcheng You , Danny Concagh , Lee Core , Kicherl Ho , Upma Sharma , Gregory T. Zugates
CPC分类号： A61L31/16 , A61F2/04 , A61F2/86 , A61F2/90 , A61F2210/0004 , A61F2210/0057 , A61F2230/0054 , A61F2250/0067 , A61K9/0024 , A61K31/337 , A61L31/06 , A61L31/10 , A61L31/148 , A61L2300/216 , A61L2300/416 , A61L2420/06 , A61L2420/08 , C08L67/04 , D04C1/06 , D10B2403/0112 , D10B2509/06
摘要： Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译： 公开了用于放置在患者的内腔内的自扩张医用植入物。 植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得它们可以用小直径导管递送。 植入物具有高回收性和所需的机械性能。
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10.发明申请公开(公告)号：US20140228745A1
公开(公告)日：2014-08-14
申请号：US14211469
申请日：2014-03-14
申请人： Upma Sharma , Rany Busold , Adam Rago , Gregory T. Zugates , Toby Freyman , Lisette Manrique Miller
发明人： Upma Sharma , Rany Busold , Adam Rago , Gregory T. Zugates , Toby Freyman , Lisette Manrique Miller
CPC分类号： A61B17/00491 , A61B2017/00398 , A61B2017/00495 , A61B2017/00544 , A61B2017/00548 , A61B2017/8838 , A61C9/0026 , A61M5/1409 , A61M5/1452 , A61M5/16804 , A61M5/19 , A61M13/003 , A61M2205/103 , B01F3/04453 , B01F5/0602 , B01F5/0604 , B01F7/00558 , B01F7/00583 , B01F13/0023 , B01F15/00253 , B01F15/00525 , B01F15/0279 , B05B7/0037 , B05B7/2421 , B05B7/2472 , B05C17/00553 , B65D81/325
摘要： Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.
摘要翻译： 提供了用于原位形成泡沫配方的输送系统。 装置可以包括各种致动机构，并且可以以各种方式将空气夹带到流体配方部件中，包括与空气混合和加入压缩气体。
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