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17 条记录 (耗时 0.022 秒)

    Carbazole derivatives
    2.
    发明授权
    Carbazole derivatives 失效
    咔唑衍生物

    公开(公告)号：US3956295A

    公开(公告)日：1976-05-11

    申请号：US489162

    申请日：1974-07-17

    申请人： Helmut Biere ,  Hanns Ahrens ,  Clemens Rufer ,  Eberhard Schroder ,  Henning Koch

    发明人： Helmut Biere ,  Hanns Ahrens ,  Clemens Rufer ,  Eberhard Schroder ,  Henning Koch

    IPC分类号： A61K31/405 ,  C07D209/88 ,  C07D209/82

    CPC分类号： C07D209/88 ,  A61K31/405 ,  Y10S514/887

    摘要： Carbazoles of the formula ##SPC1##Wherein R.sub.1 is hydroxymethyl, alkanoyloxymethyl, tetrazolyl, cyano, oximinocarbonyl, aminocarbonyl, carboxyl and salts thereof with physiologically acceptable bases and the esters thereof with physiologically acceptable alcohols and amides thereof with physiologically acceptable amines,R.sub.2 through R.sub.6 each are a hydrogen atom, halogen atom, lower alkyl, trifluoromethyl, or lower alkoxy, orR.sub.5 and R.sub.6 collectively are a five- or six-membered isocyclic ring, andR.sub.7 is a hydrocarbon of 3-8 carbon atoms or, when at least one of the R.sub.2 through R.sub.6 is other than a hydrogen atom, a hydrogen atom, methyl or ethyl,And the corresponding compounds wherein R.sub.7 is a hydrogen atom, methyl or ethyl,And the 5,6,7,8-tetrahydrocarbazoles, possess topical anti-inflammatory activity.

    摘要翻译： 式VIII的咔唑，其中R1是羟甲基，烷酰氧基甲基，四唑基，氰基，肟基羰基，氨基羰基，羧基及其盐与生理上可接受的碱，其酯与其生理上可接受的醇和酰胺与生理上可接受的胺，R2至R6各自为氢 原子，卤素原子，低级烷基，三氟甲基或低级烷氧基，或者R5和R6共同是五元或六元的环状环，并且R 7是3-8个碳原子的烃，或者当R2中的至少一个 通过R6不同于氢原子，氢原子，甲基或乙基，以及其中R7是氢原子，甲基或乙基的相应化合物，以及5,6,7,8-四氢四硼化物，POSSESS局部抗炎活性 。

    5,6,7,8:Tetrahydrocarbazole-1-carboxylic acid derivatives
    3.
    发明授权
    5,6,7,8:Tetrahydrocarbazole-1-carboxylic acid derivatives 失效
    5,6,7,8：四氢咔唑-1-羧酸衍生物

    公开(公告)号：US4057640A

    公开(公告)日：1977-11-08

    申请号：US683752

    申请日：1976-05-06

    申请人： Helmut Biere ,  Hanns Ahrens ,  Clemens Rufer ,  Eberhard Schroder ,  Henning Koch

    发明人： Helmut Biere ,  Hanns Ahrens ,  Clemens Rufer ,  Eberhard Schroder ,  Henning Koch

    IPC分类号： A61K31/405 ,  C07D209/88 ,  A61K31/40

    CPC分类号： C07D209/88 ,  A61K31/405

    摘要： Carbazoles of the formula ##STR1## wherein R.sub.1 is hydroxymethyl, alkanoyloxymethyl, tetrazolyl, cyano, oximinocarbonyl, aminocarbonyl, carboxyl and salts thereof with physiologically acceptable bases and the esters thereof with physiologically acceptable alcohols and amides thereof with physiologically acceptable amines,R.sub.2 through R.sub.6 each are a hydrogen atom, halogen atom, lower alkyl, trifluoromethyl, or lower alkoxy, orR.sub.5 and R.sub.6 collectively are a five- or six-membered isocyclic ring, andR.sub.7 is a hydrocarbon of 3-8 carbon atoms or, when at least one of the R.sub.2 through R.sub.6 is other than a hydrogen atom, a hydrogen atom, methyl or ethyl,And the corresponding compounds wherein R.sub.7 is a hydrogen atom, methyl or ethyl,And the 5,6,7,8-tetrahydrocarbazoles, possess topical anti-inflammatory activity.

    摘要翻译： 其中R 1为羟甲基，烷酰氧基甲基，四唑基，氰基，肟基羰基，氨基羰基，羧基及其盐与生理上可接受的碱，其酯与其生理上可接受的醇和酰胺与生理上可接受的胺，R 2至R 6各自相同 是氢原子，卤素原子，低级烷基，三氟甲基或低级烷氧基，或者R5和R6共同是五元或六元的环状环，而R7是3-8个碳原子的烃，或者当至少一个 R 2至R 6不是氢原子，氢原子，甲基或乙基，并且R 7是氢原子，甲基或乙基的相应化合物，以及5,6,7,8-四氢四硼化物，POSSESS主题抗体 -INFLAMMATORY活动。

    1,2-Biguanides
    4.
    发明授权
    1,2-Biguanides 失效
    1,2双胍

    公开(公告)号：US3960949A

    公开(公告)日：1976-06-01

    申请号：US486758

    申请日：1974-07-09

    申请人： Hanns Ahrens ,  Clemens Rufer ,  Helmut Biere ,  Eberhard Schroder ,  Wolfgang Losert ,  Olaf Loge ,  Ekkehard Schillinger

    发明人： Hanns Ahrens ,  Clemens Rufer ,  Helmut Biere ,  Eberhard Schroder ,  Wolfgang Losert ,  Olaf Loge ,  Ekkehard Schillinger

    IPC分类号： C07C279/26 ,  C07C129/16

    CPC分类号： C07C279/26

    摘要： 1,2-Substituted biguanides of the formula ##EQU1## wherein R.sub.1 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; a cycloalkyl group of 3-6 carbon atoms; or an aryl or aralkyl group of the formula ##SPC1##With n being the integer 0, 1 or 2 and X being hydrogen or halogen; and R'.sub.1 is a hydrogen atom or a saturated or unsaturated, straight-chain or branched hydrocarbon group of 1-12 carbon atoms; or R.sub.1 and R'.sub.1 collectively with the nitrogen atom to which they are attached are a heterocyclic ring containing one or more hetero atoms; and R.sub.2 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; or cycloalkyl of 3-6 carbon atoms, alkoxyalkyl containing a total of 2-12 carbon atoms, or alkoxy of 1-6 atoms; mixtures thereof, and pharmaceutically acceptable acid addition salts thereof, are useful in the treatment of diabetes mellitus.

    摘要翻译： 1,2-取代的式R'1 | R1-NC-NH-C-NH2的平行二亚胺平行平行NNH | R2其中R1是1-12个碳原子的饱和或不饱和的直链或支链烃，未取代或未取代的 被一个或多个氟原子取代; 3-6个碳原子的环烷基; 或下式的芳基或芳烷基：其中N为整数0,1或2且X为氢或卤素; 并且R'1是1-12个碳原子的氢原子或饱和或不饱和的直链或支链烃基; 或者R1和R'1与它们所连接的氮原子一起是含有一个或多个杂原子的杂环; R2是未被取代或被一个或多个氟原子取代的1-12个碳原子的饱和或不饱和的直链或支链烃基; 或3-6个碳原子的环烷基，总共2-12个碳原子的烷氧基烷基或1-6个原子的烷氧基; 其混合物及其药学上可接受的酸加成盐可用于治疗糖尿病。

    Nitroimidazolyl pyrimidines
    8.
    发明授权
    Nitroimidazolyl pyrimidines 失效
    硝基咪唑基嘧啶

    公开(公告)号：US3966732A

    公开(公告)日：1976-06-29

    申请号：US568117

    申请日：1975-04-14

    申请人： Clemens Rufer ,  Eberhard Schroder ,  Hans-Joachim Kessler

    发明人： Clemens Rufer ,  Eberhard Schroder ,  Hans-Joachim Kessler

    IPC分类号： C07D403/04 ,  C07D409/14 ,  C07D277/06

    CPC分类号： C07D409/14 ,  C07D403/04

    摘要： Nitroimidazolyl pyrimidines of the formula ##SPC1##And physiologically acceptable acid addition salts thereon wherein X is alkyl of 1-4 carbon atoms, R.sub.1 and R.sub.2 each are a hydrogen atom, alkyl of 1-4 carbon atoms, phenyl triflouromethyl or a monocyclic heterocyclic ring and R.sub.3 is a hydrogen atoms, alkyl of 1-4 carbon atoms, hydroxyalkoxy of 2-4 carbon atoms or an ester thereof of an alkanocarboxylic acid of 1-4 carbon atoms, oxoalkyl of 8-6 carbon atoms, or, when R.sub.1 or R.sub.2 is phenyl, alkylene having 1-2 carbon atoms in the chain joined to the 2-position of the phenyl ring possess trichomonicidal activity.

    摘要翻译： 式的硝基咪唑基嘧啶及其生理学上可接受的酸的添加剂其中X是1-4个碳原子的烷基，R1和R2各自是氢原子，1-4个碳原子的烷基，苯基三氟乙基或单环杂环，R3是 1-4个碳原子的烷基，2-4个碳原子的羟基烷氧基或其1-4个碳原子的链烷酸的酯，8-6个碳原子的氧代烷基，或当R1或R2是苯基时 在与苯环的2-位连接的链中具有1-2个碳原子的亚烷基具有杀虫活性。

    Indanyl derivatives and their use
    10.
    发明授权
    Indanyl derivatives and their use 失效
    茚基衍生物及其用途

    公开(公告)号：US4244960A

    公开(公告)日：1981-01-13

    申请号：US61779

    申请日：1979-07-27

    申请人： Eberhard Schroder ,  Clemens Rufer ,  Irmgard Bottcher ,  Joachim-Friedrich Kapp

    发明人： Eberhard Schroder ,  Clemens Rufer ,  Irmgard Bottcher ,  Joachim-Friedrich Kapp

    IPC分类号： C07C205/38 ,  C07C205/45 ,  C07D213/65 ,  C07D213/70 ,  A61K31/44 ,  A61K31/18 ,  C07D213/63

    CPC分类号： C07D213/70 ,  C07C205/38 ,  C07C205/45 ,  C07D213/65

    摘要： Indanyl derivatives of the formula ##STR1## wherein AR is phenyl, pyridyl, or phenyl or pyridyl substituted by halogen, alkyl of 1-4 carbon atoms or trifluoromethyl; X is oxygen or a sulfur; R.sub.1 is alkyl of 1-4 carbon atoms or alkyl of 1-4 carbon atoms substituted by fluorine or chlorine; A is ##STR2## Y is oxo, oximino, C.sub.1-4 -alkoximino of 1-4 carbon atoms, phenylhydrazono or p-toluenesulfonylhydrazono; n is 0, 1 or 2; R.sub.2 is alkyl of 1-4 carbon atoms, phenyl or phenyl substituted by halogen, alkyl of 1-4 carbon atoms, nitro or carboxy; Z is hydroxy, acyloxy of 1 to 6 carbon atoms, R.sub.1 SO.sub.3 -- amino, acylamino of 1 to 6 carbon atoms, R.sub.1 SO.sub.2 NH-- or cyano, and V is hydrogen, acyl of 1 to 6 carbon atoms or R.sub.1 SO.sub.2 --, and the salts thereof with physiologically acceptable bases or acids have valuable pharmacological and herbicidal activity.

    摘要翻译： 其中AR为苯基，吡啶基或苯基或被卤素取代的吡啶基，1-4个碳原子的烷基或三氟甲基; X是氧或硫; R1是1-4个碳原子的烷基或被氟或氯取代的1-4个碳原子的烷基; A是CH 2 CH 2 CH 2，CHCHCH 2，Y，Y是氧代，肟基，1-4个碳原子的C1-4-肟基，苯基亚肼基或对甲苯磺酰肼; n为0,1或2; R2是1-4个碳原子的烷基，苯基或被卤素取代的苯基，1-4个碳原子的烷基，硝基或羧基; Z是羟基，1至6个碳原子的酰氧基，R1SO3-氨基，1至6个碳原子的酰氨基，R1SO2NH-或氰基，V是氢，1至6个碳原子的酰基或R1SO2-，其盐与 生理上可接受的碱或酸具有有价值的药理学和除草活性。