Solid form and method for preparing the same
    3.
    发明授权
    Solid form and method for preparing the same 有权
    固体形式及其制备方法

    公开(公告)号:US09084822B2

    公开(公告)日:2015-07-21

    申请号:US13871491

    申请日:2013-04-26

    CPC classification number: A61K47/34 A61K9/0024

    Abstract: The disclosure provides a solid form and a method for preparing the same. The solid form consists essentially of a biodegradable copolymer and an amide-containing compound. The biodegradable copolymer is semi-crystalline due to the dipole-dipole interaction between the biodegradable copolymer and the urea. The method for preparing the above solid form includes: dissolving a biodegradable copolymer and an amide-containing compound in water at a first temperature, obtaining a solution; cooling the solution at a second temperature to form a solid mixture; and the solid mixture is subjected to a freeze-drying process at a third temperature.

    Abstract translation: 本公开提供了一种固体形式及其制备方法。 固体形式基本上由可生物降解的共聚物和含酰胺的化合物组成。 由于可生物降解的共聚物和尿素之间的偶极 - 偶极相互作用,生物降解性共聚物是半结晶的。 制备上述固体形式的方法包括:在第一温度下将可生物降解的共聚物和含酰胺的化合物溶解在水中,得到溶液; 在第二温度下冷却溶液以形成固体混合物; 并将固体混合物在第三温度下进行冷冻干燥处理。

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