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公开(公告)号:US12258546B2
公开(公告)日:2025-03-25
申请号:US17561117
申请日:2021-12-23
Applicant: Industrial Technology Research Institute
Inventor: Hsin-Yi Hsu , Yang-Cheng Lin , Chao-Hong Hsu , Yu-Bing Liou , Li-Hsin Lin , Hsin-Hsin Shen , Yu-Chi Wang , Chang-Chou Li , Chih-Hung Huang
Abstract: A cell and tissue sheet forming package includes a container body, a membrane, a sliding door plate and a sealing film. The sliding door plate is disposed slidably on a top of the container body to cover or expose the membrane. The sliding door plate has a hole and a passive magnetic assembly. The cell injection equipment includes a carrier, an injection mechanism and a drive mechanism. The carrier carries the package, and the drive mechanism moves the carrier and the injection mechanism to have the injection mechanism to inject a solution, through the hole, into the package. A heating element of the carrier is introduced to heat the membrane and the solution to transform the solution into a colloid sheet on the membrane. Then, the positive magnetic assembly engages magnetically the passive magnetic assembly to slide the sliding door plate to expose the colloid sheet on the membrane.
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公开(公告)号:US12227759B2
公开(公告)日:2025-02-18
申请号:US17126942
申请日:2020-12-18
Applicant: Industrial Technology Research Institute
Inventor: Chia-Jung Lu , Jing-En Huang , Liang-Cheng Su , Hsin-Hsin Shen , Yuchi Wang , Ying-Hsueh Chao , Li-Hsin Lin , Hsiu-Hua Huang
Abstract: A temperature-sensitive cell culture composition is provided. The temperature-sensitive cell culture composition includes a hydrogel, a cellulose, a gelatin and a collagen. Based on 1 part by weight of the collagen, a content of the hydrogel is between 0.03 parts by weight and 60 parts by weight, a content of the cellulose is between 150 parts by weight and 360 parts by weight, and a content of the gelatin is between 21 parts by weight and 12 parts by weight. In addition, a method for using the temperature-sensitive cell culture composition, a method for forming the temperature-sensitive cell culture composition, and a use of the temperature-sensitive cell culture composition are also provided.
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公开(公告)号:US09084822B2
公开(公告)日:2015-07-21
申请号:US13871491
申请日:2013-04-26
Applicant: Industrial Technology Research Institute
Inventor: Hsin-Hsin Shen , Yu-Bing Liou , Chin-Fu Chen , Li-Hsin Lin , Hsiu-Hua Huang , Ying-Hsueh Chao , Meng-Yow Hsieh , Miao-Tzu Chen , Chih-Bing Hung
CPC classification number: A61K47/34 , A61K9/0024
Abstract: The disclosure provides a solid form and a method for preparing the same. The solid form consists essentially of a biodegradable copolymer and an amide-containing compound. The biodegradable copolymer is semi-crystalline due to the dipole-dipole interaction between the biodegradable copolymer and the urea. The method for preparing the above solid form includes: dissolving a biodegradable copolymer and an amide-containing compound in water at a first temperature, obtaining a solution; cooling the solution at a second temperature to form a solid mixture; and the solid mixture is subjected to a freeze-drying process at a third temperature.
Abstract translation: 本公开提供了一种固体形式及其制备方法。 固体形式基本上由可生物降解的共聚物和含酰胺的化合物组成。 由于可生物降解的共聚物和尿素之间的偶极 - 偶极相互作用,生物降解性共聚物是半结晶的。 制备上述固体形式的方法包括:在第一温度下将可生物降解的共聚物和含酰胺的化合物溶解在水中,得到溶液; 在第二温度下冷却溶液以形成固体混合物; 并将固体混合物在第三温度下进行冷冻干燥处理。
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公开(公告)号:US12054612B2
公开(公告)日:2024-08-06
申请号:US17561133
申请日:2021-12-23
Applicant: Industrial Technology Research Institute
Inventor: Yun-Chung Teng , Jen-Huang Huang , Ying-Wen Shen , Yu-Bing Liou , Hsin-Yi Hsu , Li-Hsin Lin , Yuchi Wang , Hsin-Hsin Shen
CPC classification number: C08L89/06 , A61L27/26 , A61L27/52 , B33Y80/00 , C08J3/24 , C12N5/0018 , C08J2389/06 , C08J2489/06 , C08L2203/02 , C08L2205/02 , C08L2205/16 , C08L2312/00 , C12N2500/34
Abstract: A bioprintable material is provided. The bioprintable material includes a hydrogel and microfilaments mixed in the hydrogel. The hydrogel includes a first collagen. The microfilament includes a second collagen. The diameter of the microfilament is ranging from 5 microns to 200 microns. The weight ratio of the microfilaments to the first collagen is ranging from 0.01:1 to 10:1.
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公开(公告)号:US11760853B2
公开(公告)日:2023-09-19
申请号:US17537728
申请日:2021-11-30
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor: Wei-Hong Chang , Ching-Mei Chen , Grace H. Chen , Hsin-Hsin Shen , Yuchi Wang , Ming-Chia Yang , Li-Hsin Lin , Sen-Lu Chen , Yi-Hsuan Lee , Jian-Wei Lin , Liang-Cheng Su
CPC classification number: C08J5/18 , A61L24/043 , B32B9/02 , B32B9/045 , B32B27/36 , C08J2335/02 , A61L24/043 , C08L5/04 , A61L24/043 , C08L67/04 , A61L24/043 , C08L29/04 , A61L24/043 , C08L71/02
Abstract: An anti-curling film is provided. The anti-curling film includes a first portion and a second portion covering the first portion. The first portion includes polylactic acid (PLA), polycaprolactone (PCL), polyethylene glycol dimethacrylate (PEGDMA) and a photoinitiator. The second portion includes polycaprolactone (PCL), gelatin, hyaluronic acid (HA), alginate (AA), polyvinyl alcohol (PVA) or a combination thereof.
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公开(公告)号:US09107979B2
公开(公告)日:2015-08-18
申请号:US13870178
申请日:2013-04-25
Applicant: Industrial Technology Research Institute
Inventor: Li-Hsin Lin , Hsin-Hsin Shen , Ying-Hsueh Chao , Hsiu-Hua Huang , Yu-Bing Liou , Chih-Bing Hung , Chin-Fu Chen
CPC classification number: A61L27/26 , A61K9/006 , A61K9/70 , A61K9/7007 , A61L27/54 , A61L27/56 , A61L27/58 , C08L67/04 , C08L71/02
Abstract: A bioresorbable porous film, including a blend mixture of polylactic acid and at least two kinds of polyethylene glycol, wherein the at least two kinds of polyethylene glycol include a first polyethylene glycol, which is in a solid form under ambient temperature and atmospheric pressure, and a second polyethylene glycol, which is in a liquid form under ambient temperature and atmospheric pressure is provided. The film has a porosity of 10%-90%.
Abstract translation: 一种生物可吸收多孔膜,其包括聚乳酸和至少两种聚乙二醇的混合物,其中所述至少两种聚乙二醇包括在环境温度和大气压下为固体形式的第一聚乙二醇,以及 提供在环境温度和大气压下为液体形式的第二聚乙二醇。 该膜的孔隙率为10%-90%。
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