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公开(公告)号：US08697137B2
公开(公告)日：2014-04-15
申请号：US10220982
申请日：2001-03-23
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61K9/50
CPC classification number: A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
Abstract translation: 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地输送用于栓塞药物治疗的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US20060063732A1
公开(公告)日：2006-03-23
申请号：US11253435
申请日：2005-10-18
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
CPC classification number: A61K9/0019 , A61K9/1635 , A61K48/00 , A61K48/0008 , A61K48/0041
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) physically linked to a transfection agent for use in embolization gene therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions., using the injectable compositions.
Abstract translation: 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地递送与用于栓塞基因治疗的转染剂物理连接的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于使用可注射组合物治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US06790456B2
公开(公告)日：2004-09-14
申请号：US10222819
申请日：2002-08-19
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61F1300
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.
Abstract translation: 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。
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公开(公告)号：US09308169B2
公开(公告)日：2016-04-12
申请号：US13462004
申请日：2012-05-02
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61K9/50 , A61K9/16 , A61K31/715 , A61K45/06
CPC classification number: A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
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公开(公告)号：US09017710B2
公开(公告)日：2015-04-28
申请号：US12197187
申请日：2008-08-22
Applicant: Jean-Marie Vogel , Egisto Boschetti , Richard Thomas
Inventor： Jean-Marie Vogel , Egisto Boschetti , Richard Thomas
IPC: A61F2/00 , A61K9/14 , A01N65/00 , A61L27/38 , A61L27/50 , A61L31/00 , A61L31/14 , A61K31/78 , A61K31/785
CPC classification number: A61K9/14 , A61K31/78 , A61K31/785 , A61L27/3804 , A61L27/3839 , A61L27/50 , A61L31/005 , A61L31/14 , A61L2400/06
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.
Abstract translation: 本发明涉及包含可用于组织膨胀的生物相容性，可溶胀，亲水，无毒和基本上为球形的微球的可注射组合物。 本发明还涉及使用可注射组合物的组织膨胀方法，特别是用于治疗胃食管反流病，尿失禁或尿反流疾病的方法。
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Patent Agency Ranking
公开(公告)号：US06436424B1
公开(公告)日：2002-08-20
申请号：US09528990
申请日：2000-03-20
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61F1300
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.
Abstract translation: 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。
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公开(公告)号：US09205053B2
公开(公告)日：2015-12-08
申请号：US12534070
申请日：2009-07-31
Applicant: Jean-Marie Vogel , Richard Thomas , Egisto Boschetti
Inventor： Jean-Marie Vogel , Richard Thomas , Egisto Boschetti
IPC: A61K9/14 , A61K9/00 , A61K47/48 , A61K49/04 , A61L27/38 , A61L27/50 , A61L31/00 , A61L31/14 , A61K31/78 , A61K31/785 , A61K9/16
CPC classification number: A61K9/14 , A61K9/0019 , A61K9/16 , A61K9/1635 , A61K9/1641 , A61K31/78 , A61K31/785 , A61K47/6925 , A61K47/6927 , A61K49/0442 , A61K49/048 , A61L27/38 , A61L27/50 , A61L31/005 , A61L31/14 , A61L2400/06
Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.
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公开(公告)号：US20110033508A1
公开(公告)日：2011-02-10
申请号：US12534070
申请日：2009-07-31
Applicant: Jean-Marie VOGEL , Richard Thomas , Egisto Boschetti
Inventor： Jean-Marie VOGEL , Richard Thomas , Egisto Boschetti
IPC: A61K8/02 , A61K9/14 , A61K31/74 , A61K31/78 , A61K8/81 , A61K31/765 , A61K8/89 , A61K31/785 , A61P17/02 , A61P1/04 , A61P13/00 , A61Q19/00 , A61M5/178
CPC classification number: A61K9/14 , A61K9/0019 , A61K9/16 , A61K9/1635 , A61K9/1641 , A61K31/78 , A61K31/785 , A61K47/6925 , A61K47/6927 , A61K49/0442 , A61K49/048 , A61L27/38 , A61L27/50 , A61L31/005 , A61L31/14 , A61L2400/06
Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.
Abstract translation: 本发明涉及用于真皮增生和组织膨胀的弹性，亲水和基本上球形的微球。 本发明提供了包含微球和用于真皮增生的生物相容性载体的可注射组合物。 本发明还提供使用可注射组合物的皮肤增强和组织膨胀的方法，特别是用于治疗皮肤轮廓缺陷，胃食管反流病，尿失禁和尿反流疾病的方法。
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公开(公告)号：US07060298B2
公开(公告)日：2006-06-13
申请号：US10029294
申请日：2001-12-28
Applicant: Jean Marie Vogel , Richard Thomas , Egisto Boschetti
Inventor： Jean Marie Vogel , Richard Thomas , Egisto Boschetti
CPC classification number: A61K9/0034 , A61K9/1635 , A61K9/1641 , A61K47/62 , A61K47/6927 , A61K49/0442 , A61K49/048
Abstract: The invention encompasses the treatment of urinary incontinence, gastroesophageal reflux disease and the amelioration of skin wrinkles using biocompatible hydrophilic cationic microparticles and a cell adhesion promoter.
Abstract translation: 本发明包括使用生物相容的亲水性阳离子微粒和细胞粘附促进剂治疗尿失禁，胃食管反流疾病和改善皮肤皱纹。
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公开(公告)号：US08741351B2
公开(公告)日：2014-06-03
申请号：US13371964
申请日：2012-02-13
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61K9/50
CPC classification number: A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
Abstract translation: 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地输送用于栓塞药物治疗的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于治疗血管生成和非血管生成依赖性疾病的方法。
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