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    Biomimetic vascular network and devices using the same
    10.
    发明授权
    Biomimetic vascular network and devices using the same 有权
    生物模拟血管网和使用该装置的装置

    公开(公告)号：US08951302B2

    公开(公告)日：2015-02-10

    申请号：US12576826

    申请日：2009-10-09

    申请人： Howard I. Pryor ,  Ira Spool ,  David M. Hoganson ,  Joseph P. Vacanti ,  Jeffrey T. Borenstein

    发明人： Howard I. Pryor ,  Ira Spool ,  David M. Hoganson ,  Joseph P. Vacanti ,  Jeffrey T. Borenstein

    IPC分类号： A61F2/04 ,  A61F2/06 ,  G01N33/50

    CPC分类号： A61F2/06 ,  A61F2/022 ,  A61F2/04 ,  A61F2/062 ,  A61F2002/068 ,  G01N33/5008 ,  G06F19/00

    摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.

    摘要翻译： 本发明提供了制造包括流体网络的支架的方法，包括以下步骤：（a）产生用于封闭腔室并向细胞提供流体的初始血管层，初始血管层具有用于流体的通道网络; （b）将初始血管层转化为用于流体动力学分析的模型; （c）基于从由特定流体的特性，输入压力，输出压力，总体流速及其组合组成的组中选择的期望参数来分析初始血管层，以确定网络内的纯粹的应力和速度 渠道; （d）测量纯应力和速度，并将获得的值与预定值进行比较; （e）确定剪切应力或速度是否大于或小于预定值，和（f）任选地修饰初始血管层并重复步骤（b） - （e）。 本发明还提供包含用于组织层的血管层的组合物以及具有血管层和试剂盒的医疗装置。