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公开(公告)号：US20150306172A1
公开(公告)日：2015-10-29
申请号：US14717872
申请日：2015-05-20
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中R1，R2，R3，R4，R5和AB如本文所定义，其为非免疫抑制性，亲环蛋白结合，mPTP阻断剂，因此可用于预防或治疗疾病或病症 例如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US09072696B2
公开(公告)日：2015-07-07
申请号：US14037644
申请日：2013-09-26
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或 疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US20140134132A1
公开(公告)日：2014-05-15
申请号：US14037644
申请日：2013-09-26
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或 疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US09637482B2
公开(公告)日：2017-05-02
申请号：US15304044
申请日：2015-04-22
申请人： Jiping Fu , Xianming Jin , Subramanian Karur , Guillaume Lapointe , Patrick Lee , Zachary Kevin Sweeney
发明人： Jiping Fu , Xianming Jin , Subramanian Karur , Guillaume Lapointe , Patrick Lee , Zachary Kevin Sweeney
IPC分类号： C07D417/10 , C07D261/04 , A61K31/421 , A61K45/06 , C07D413/04 , A61K31/4439 , C07D413/10 , A61K31/422 , A61K31/5377
CPC分类号： C07D261/04 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D413/10 , C07D417/10
摘要： This invention pertains generally to compounds of Formula I and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention pertains to methods and compositions for treating infections caused by Gram-negative bacteria.
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公开(公告)号：US09549916B2
公开(公告)日：2017-01-24
申请号：US14969930
申请日：2015-12-15
申请人： Jiping Fu , Xianming Jin , Subramanian Karur , Guillaume Lapointe , Ann Marie Madera , Zachary Kevin Sweeney
发明人： Jiping Fu , Xianming Jin , Subramanian Karur , Guillaume Lapointe , Ann Marie Madera , Zachary Kevin Sweeney
IPC分类号： A61K31/42 , A61K45/06 , A61K31/422 , C07D261/08 , C07D413/12 , C07D413/06
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K45/06 , C07D413/06 , C07D413/12 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K2300/00
摘要： This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.
摘要翻译： 本发明一般涉及本文所述的式I化合物和含有这些化合物的组合物，以及使用这些化合物治疗细菌感染的方法。 在某些方面，本发明提供包含这些化合物的方法和组合物，用于治疗革兰氏阴性菌引起的感染。
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公开(公告)号：US08815882B2
公开(公告)日：2014-08-26
申请号：US13292668
申请日：2011-11-09
申请人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Zachary Kevin Sweeney
发明人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Zachary Kevin Sweeney
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D403/14 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译： 式I化合物或其药学上可接受的盐，其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。 还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。
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公开(公告)号：US20080293664A1
公开(公告)日：2008-11-27
申请号：US12082069
申请日：2008-04-08
IPC分类号： A61K31/5025 , A61P31/18 , C07D471/04 , A61K31/7072 , A61K31/7068 , A61K31/551 , A61K31/513 , A61K31/496 , A61K31/538 , A61K31/708 , A61K31/437 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Compounds of formula I, wherein R1, R2, R3, R4, Ra, X, X1, and Y are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
摘要翻译： 其中R1，R2，R3，R4，Ra，X，X1和Y如本文所定义的式I化合物或其药学上可接受的盐抑制HIV-1逆转录酶，并提供预防和治疗HIV-1的方法 感染和治疗艾滋病和/或ARC。 本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式I化合物的组合物。
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公开(公告)号：US07166738B2
公开(公告)日：2007-01-23
申请号：US11112591
申请日：2005-04-22
IPC分类号： C07C311/16 , C07C311/17 , C07C311/18
CPC分类号： C07C255/54 , C07C311/24 , C07C311/46 , C07C311/51 , C07C317/40 , C07C317/44 , C07C323/49 , C07C2601/14 , C07D275/02 , C07D295/067
摘要： The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1—R5, R7a, R7b, R7c, R8—R10, X1, X2 m, n, o and p are as defined herein
摘要翻译： 本发明提供用于治疗或预防HIV感染或治疗AIDS或ARC的化合物，其包括给予式I的化合物，其中Ar，R 1，R 5，R R 7，R 7，R 7，R 8，R 8，R 10，X 10， m，n，o和p如本文所定义
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公开(公告)号：US08026362B2
公开(公告)日：2011-09-27
申请号：US12156228
申请日：2008-05-30
IPC分类号： C07D239/02 , C07D233/00
CPC分类号： C07D239/22 , C07D233/72 , C07D233/78 , C07D239/54 , C07D239/545 , C07D239/553
摘要： Compounds of formula I, wherein R1, X1, X2 and A, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
摘要翻译： 其中R 1，X 1，X 2和A如本文所定义的式I化合物或其药学上可接受的盐抑制HIV-1逆转录酶，并提供预防和治疗HIV-1感染的方法以及治疗AIDS和/ 或ARC。 本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式I化合物的组合物。
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公开(公告)号：US20100041648A1
公开(公告)日：2010-02-18
申请号：US12606320
申请日：2009-10-27
IPC分类号： A61K31/535 , A61K31/18 , A61K31/165 , A61K31/425 , A61P31/12 , A61P31/18
CPC分类号： A61K31/277
摘要： The present invention provides compositions for treating an HIV infection comprising administering a compound according to formula I where Ar, R1-R5, R11c and X1 are as defined herein with at least one carrier, excipient or diluent.
摘要翻译： 本发明提供用于治疗HIV感染的组合物，包括给予式I化合物，其中Ar，R 1 -R 5，R 11c和X 1如本文所定义与至少一种载体，赋形剂或稀释剂。
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