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公开(公告)号：US20120202276A1
公开(公告)日：2012-08-09
申请号：US13036623
申请日：2011-02-28
IPC分类号： C12M1/40
CPC分类号： C12Q1/6869 , C12N9/1252 , C12Y207/07007 , G01N27/4145
摘要： Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for using such modified proteins in ion-producing reactions, such as ion-based nucleic acid sequencing reactions.
摘要翻译： 提供了包含修饰的蛋白质，特别是具有改变的缓冲性质的经修饰的核酸结合蛋白质的方法，组合物，系统，装置和试剂盒。 例如，在一些实施方案中，描述了形成包含一个或多个氨基酸修饰以获得所需pKa值的修饰蛋白质的方法。 此外，本发明提供了在离子产生反应中使用这些修饰蛋白质的方法，例如基于离子的核酸测序反应。
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公开(公告)号：US20110318748A1
公开(公告)日：2011-12-29
申请号：US13035177
申请日：2011-02-25
IPC分类号： C12Q1/68
CPC分类号： C12N9/1252
摘要： Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for using such modified proteins in ion-producing reactions, such as ion-based nucleic acid sequencing reactions.
摘要翻译： 提供了包含修饰的蛋白质，特别是具有改变的缓冲性质的经修饰的核酸结合蛋白质的方法，组合物，系统，装置和试剂盒。 例如，在一些实施方案中，描述了形成包含一个或多个氨基酸修饰以获得所需pKa值的修饰蛋白质的方法。 此外，本发明提供了在离子产生反应中使用这些修饰蛋白质的方法，例如基于离子的核酸测序反应。
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公开(公告)号：US11922559B2
公开(公告)日：2024-03-05
申请号：US17670630
申请日：2022-02-14
申请人： John Davidson , Neil Compson
发明人： John Davidson , Neil Compson
IPC分类号： G06T15/08 , B29C64/393 , B33Y50/02 , G06T7/90
CPC分类号： G06T15/08 , B29C64/393 , G06T7/90 , B33Y50/02
摘要： Herein is disclosed a method for ink or coating density compensation by means of applying calculated additional ink/coating to the pre-decorated substrate or film, and by additionally, if needed, apply colour-correction to pre-decoration print files to compensate for higher-than-desired ink density colour shifts. The method includes the steps of providing a flat polymer web having a uniform grid pattern of grid markers printed thereon, and then thermally transforming the web to form a three-dimensional target grid. The target grid is then digitized and the change in the spacing of the grid markers is measured and recorded. The recorded transformed spacing for each grid marker is then used to modify the initial graphics file to compensate for ink-density irregularities resulting from the shrinking and stretching deformations of the substrate during thermal transformation.
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公开(公告)号：US07555157B2
公开(公告)日：2009-06-30
申请号：US10236269
申请日：2002-09-06
申请人： Geoff Davidson , Glen Arendt , John P. Mellor , John Davidson
发明人： Geoff Davidson , Glen Arendt , John P. Mellor , John Davidson
IPC分类号： G06K9/00
摘要： A system and a method for transforming graphical images. Graphical images are adapted by the present invention to be applied to a three-dimensional topography of a substrate. After the image is applied to the substrate, the image then appears in proportion and conforms to the (topography of the substrate. In an embodiment, the present invention comprises a method for creating at least one transformed graphical image. The topography of a substrate is measured by using a digitizing apparatus to obtain at least one image of the topography of a measurement article. The digitizing apparatus comprises at least one sensor that is electronically interconnected with a computer memory. The at least one image of the measurement article is transmitted into the computer memory. A graphical image is transformed in computer memory in accordance with the measurements of the topography of the measurement article to result in a transformed graphical image.
摘要翻译： 一种用于转换图形图像的系统和方法。 图形图像由本发明适用于衬底的三维形貌。 在将图像应用于基板之后，图像按比例显示，并与（基板的形貌）一致。在一个实施例中，本发明包括用于产生至少一个变换图形图像的方法，基板的形貌是 通过使用数字化装置测量以获得测量物品的形貌的至少一个图像数字化装置包括与计算机存储器电子互连的至少一个传感器，测量物品的至少一个图像被传送到 计算机存储器。根据测量物品的地形的测量，将图形图像转换到计算机存储器中，以产生经变换的图形图像。
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公开(公告)号：US20070189526A1
公开(公告)日：2007-08-16
申请号：US11335382
申请日：2006-01-19
申请人： John Davidson
发明人： John Davidson
IPC分类号： H04L9/00
CPC分类号： H04L9/0618 , H04L2209/24
摘要： The present invention is a method for secure and flexible key schedule generation, which includes loading a key schedule algorithm and a cryptographic algorithm into a cryptographic engine. The method further includes loading the cryptographic algorithm, when selected, into a cryptographic co-processor. The method further includes loading the key schedule algorithm into a separate virtual machine.
摘要翻译： 本发明是一种用于安全和灵活的密钥调度生成的方法，其包括将密钥调度算法和密码算法加载到密码引擎中。 该方法还包括将加密算法在选择时加载到密码协处理器中。 该方法还包括将密钥调度算法加载到单独的虚拟机中。
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公开(公告)号：US20130344561A1
公开(公告)日：2013-12-26
申请号：US13984346
申请日：2012-02-08
申请人： John Davidson , Theo Nikiforov , Guobin Luo
发明人： John Davidson , Theo Nikiforov , Guobin Luo
IPC分类号： C12N11/10
CPC分类号： C12N11/10 , C12N9/1241 , C12Q1/68 , G01N2333/9126
摘要： In some embodiments, the disclosure relates generally to methods as well as related compositions, systems, kits and apparatus comprising linking proteins to target compounds and/or to locations of interest using tethers. For example, the tether can used to link the protein to a target compound, for example, to link an enzyme to a substrate. Similarly, the tether can be used to link the protein at or near a desired location on a surface. In one group of embodiments, the tether includes a polynucleotide and the target compound or location on the surface includes another polynucleotide that is capable of hybridizing to the tether. In such bodiments, the tether can be used to link the protein to the target compound or location using nucleic acid hybridization.
摘要翻译： 在一些实施方案中，本公开一般涉及方法以及相关组合物，系统，试剂盒和装置，其包括使用系链将蛋白质与靶化合物和/或感兴趣的位置连接。 例如，系链可以用于将蛋白质连接到目标化合物，例如将酶连接到底物上。 类似地，系链可用于将蛋白质链接在表面上的期望位置处或附近。 在一组实施方案中，系链包括多核苷酸，并且目标化合物或表面上的位置包括能够与系链杂交的另一多核苷酸。 在这样的实验中，系链可用于使用核酸杂交将蛋白质与靶化合物或位置连接。
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7.发明申请公开(公告)号：US20060147523A1
公开(公告)日：2006-07-06
申请号：US11361982
申请日：2006-02-27
申请人： Alan Fergusson , John Davidson
发明人： Alan Fergusson , John Davidson
CPC分类号： A61K31/202 , A61K31/05 , A61K31/557 , A61K31/56 , A61K31/575 , A61K2300/00
摘要： A nutritional supplement composed of phytosterols, anti-oxidants, and other complexes, including essential fatty acids, amino acids, peptides, proline rich polypeptides and digestive enzymes is described. The nutritional supplement may be used by individuals suffering from or at risk of developing immune system diseases; breast cancer, colon and prostate cancer; HIV infection; high cholesterol; or enlarged prostate. In the preferred form, the invention comprises phytosterols and antioxidants, together with essential fatty acids derived from amino acids, short chain peptides, proline rich polypeptides and digestive enzymes, and a microcellulose filler.
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公开(公告)号：US06740038B2
公开(公告)日：2004-05-25
申请号：US09966359
申请日：2001-10-01
IPC分类号： A61B812
CPC分类号： A61B5/02007 , A61B5/4076 , A61B5/411 , A61B5/7264 , A61B8/06 , A61B8/56 , G01S7/52036 , G01S15/8915 , G01S15/8979 , G06F19/00 , G06Q10/10 , G06Q50/22
摘要： The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. In one of many embodiments, the present invention further provides an expert system for achieving the above.
摘要翻译： 本发明一般涉及用于评估血管中的血流量，用于评估血管健康，进行临床试验，筛选用于不良反应的治疗干预的系统和方法，以及用于评估危险因素，治疗和物质（包括治疗）的影响 物质，血管，特别是脑血管，都是通过测量一个或多个血管中的血液流动的各种参数而实现的，并在确定的物质中分析结果。 血流相关参数包括平均流速，收缩期加速度和搏动指数。 通过测量和分析这些参数，可以确定特定血管，多个血管和个体的血管健康。 这样的测量还可以确定物质是否对血管健康具有有害或有利的作用。 在许多实施例中的一个实施例中，本发明还提供了一种用于实现上述的专家系统。
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公开(公告)号：US20220036651A1
公开(公告)日：2022-02-03
申请号：US16945346
申请日：2020-07-31
申请人： John Davidson , Neil Compson
发明人： John Davidson , Neil Compson
摘要： A method for transforming a two-dimensional graphic image into a two-dimensional distorted image which can then be used to recreate an accurate representation of the two-dimensional graphic image when applied onto a 3D surface. The method includes the steps of producing and identifying a target 3D grid from a plurality of flat polymer webs each having a grid pattern printed thereon, the target 3D grid bearing an accurate representation of the 3D surface. The three-dimensional shape of the target grid is then digitized to form a geometric model of the target grid as a series of data points. Creating a uniform smooth 3D model from the series of data points and then texture mapping the two-dimensional graphic image onto the uniform smooth 3D model to create a texture map. The two-dimensional distorted image is then created from the texture map and the two-dimensional graphic image.
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公开(公告)号：US07364555B1
公开(公告)日：2008-04-29
申请号：US11141821
申请日：2005-06-01
申请人： John Davidson
发明人： John Davidson
CPC分类号： A61H1/0274 , A61H2201/1276 , A63B21/068 , A63B21/4017 , A63B21/4043 , A63B23/03508 , A63B23/1245 , Y10S482/904 , Y10S482/907
摘要： A self-assisted shoulder passive range of motion (SA-PROM) apparatus. The apparatus includes a forearm support adapted to receive the forearm of the affected arm, a double pulley assembly, a single pulley connectable to an elevated support such as an upper door edge, and a main support rope, one end of which is attached to the double pulley, the other end having an enlarged handle. A central portion of the main support rope is engagable over the single pulley. A secondary rope arrangement which is preferably formed of a single length of rope, is attached to each of a plurality of holes formed through said forearm support in proximity to each end and each side margin of the forearm support and arranged over the secondary pulleys to self-regulate pitch and roll movement of the forearm support. The affected arm may be passively raised and lowered through a range of motion by pulling on the handle with the unaffected arm.
摘要翻译： 自助肩膀被动运动范围（SA-PROM）装置。 该装置包括适于接收受影响的臂的前臂的前臂支撑件，双皮带轮组件，可连接到诸如上门边缘的升高的支撑件的单个滑轮以及主支撑绳索，其一端附接到 双皮带轮，另一端具有扩大的手柄。 主支撑绳索的中心部分可以在单个滑轮上接合。 优选地由单个长度的绳索形成的次级绳索装置附接到通过所述前臂支撑件形成的多个孔中的每一个靠近前臂支撑件的每个端部和每个侧边缘并且布置在次级带轮上以自身 调节前臂支架的俯仰运动。 通过用未受影响的臂拉动手柄，受影响的手臂可以被动地升高和降低一定范围的运动。
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