公开(公告)号：US11944998B2

公开(公告)日：2024-04-02

申请号：US16822018

申请日：2020-03-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byung Chul Lee ,  Dong-Hyun Kang ,  Jin soo Park ,  Tae Song Kim

IPC: B06B1/02 ,  B81B3/00 ,  B81C1/00

CPC classification number: B06B1/0292 ,  B81B3/0086 ,  B81C1/00698 ,  B81B2201/0271 ,  B81B2203/0127 ,  B81B2207/07 ,  B81C2201/0171 ,  B81C2201/0178 ,  B81C2201/0194

Abstract: A method of fabricating a capacitive micromachined ultrasonic transducer (CMUT) according to one aspect of the present invention may include forming, on a semiconductor substrate, a first region implanted with impurity ions at a first average concentration and a second region implanted with no impurity ions or implanted with the impurity ions at a second average concentration lower than the first average concentration, forming an insulating layer by oxidizing the semiconductor substrate wherein the insulating layer includes a first oxide layer having a first thickness on at least a part of the first region and a second oxide layer having a second thickness smaller than the first thickness on at least a part of the second region, and forming a membrane layer on the insulating layer such that a gap is defined between the second oxide layer and the membrane layer.

公开(公告)号：US20190064175A1

公开(公告)日：2019-02-28

申请号：US15954858

申请日：2018-04-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Song Kim ,  Rhokyun Kwak ,  Won Bae Han

IPC: G01N33/68

Abstract: Disclosed area methods for fabricating three-dimensional artificial lipid biomembrane structure arrays with sufficient reaction area and high stability on a substrate in a simpler and easier manner. The methods use constituent lipids of real cell membranes and a plurality of microwells formed on a substrate. The methods can more effectively provide biomimetic three-dimensional lipid membrane structure arrays that possess structural and/or functional properties of cell membranes.

公开(公告)号：US11313828B2

公开(公告)日：2022-04-26

申请号：US14994389

申请日：2016-01-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ji Yoon Kang ,  Kyeong-Sik Shin ,  Jae-hoon Ji ,  Kyoseon Hwang ,  Tae Song Kim

IPC: G01N27/416 ,  G01N27/327 ,  G01N33/543

Abstract: The biosensor includes a substrate, an electrode pattern positioned on the substrate, a passivation layer which is formed with a plurality of holes spaced apart from each other, and a bead positioned at one or more holes among the plurality of holes, and to which an antibody is attached, the electrode pattern includes a first electrode pattern part and a second electrode pattern part spaced apart from the first electrode pattern part, which has a same height as a height of the first electrode pattern part, and forms an electric field with the first electrode pattern part.

公开(公告)号：US10585105B2

公开(公告)日：2020-03-10

申请号：US15565503

申请日：2016-05-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ji Yoon Kang ,  Kyeong Sik Shin ,  Jae Hoon Ji ,  Tae Song Kim ,  Young Soo Kim ,  Sang Yun Kim

IPC: G01N33/53 ,  G01N25/18 ,  G01N24/00 ,  G01N27/00 ,  G01N33/68 ,  G01N27/02

Abstract: The present invention relates to a method for diagnosing a disease using an analysis of oligomer of an abnormal aggregated protein includes: (1) preparing a body fluid sample including at least one of blood, blood plasma, blood serum, saliva, urine, tear, and mucus; (2) making a dilution of the body fluid sample; (3) using a biosensor to measure and detect an aggregated protein in the diluted body fluid sample; (4) analyzing a signal change of the biosensor caused by the dilution of the aggregated protein to determine a slope according to the dilution from the measurements; and (5) analyzing a proportion of the oligomer from the slope according to the dilution to make a diagnosis. The method uses a biosensor to measure the impedance and the protein concentration of blood and detects the slope according to the numerical value of the monomer and the oligomer to diagnose normal or abnormal protein aggregation or the associated diseases with more accuracy.

公开(公告)号：US09753027B2

公开(公告)日：2017-09-05

申请号：US14575129

申请日：2014-12-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyoseon Hwang ,  Tae Song Kim ,  Rhokyun Kwak ,  Won Woo Cho ,  Myung Sic Chae

IPC: G01N29/00 ,  G01H11/08 ,  H01L41/08 ,  G01N33/53 ,  G01N33/543 ,  G01N29/02 ,  G01N29/036

CPC classification number: G01N33/5302 ,  G01N29/022 ,  G01N29/036 ,  G01N33/54373 ,  G01N33/5438 ,  G01N2291/0427

Abstract: The present disclosure relates to a cantilever sensor, and a biosensor having the same, wherein the cantilever sensor including a slit formed on a flat board and a cantilever formed by the slit, a first electrode formed on the cantilever, and a second electrode formed on the flat board countered to the first electrode about the slit, wherein the electrodes are formed on the cantilever sensor having the slit, whereby sensing can be conducted by an electric method, through which the sensor can be effectively miniaturized.

公开(公告)号：US10006920B2

公开(公告)日：2018-06-26

申请号：US14787146

申请日：2014-04-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Soo Kim ,  Dong Jin Kim ,  Hye Yun Kim ,  Soo Min Cho ,  Tae Song Kim ,  Hyunjin Kim ,  Sejin Lee ,  Kyoseon Hwang ,  Jee Hoon Roh ,  Jae-Young Koh

IPC: G01N33/68 ,  A61K38/17 ,  C07K14/47

CPC classification number: G01N33/6893 ,  A61K38/1716 ,  C07K14/4711 ,  G01N33/6827 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: The present disclosure relates to a diagnostic kit capable of accurately diagnosing diseases or disorders related with abnormal aggregation or misfolding of proteins, including disorders or diseases caused by aggregation of β-amyloid such as Alzheimer's disease as well as disorders or diseases caused by aggregation of other proteins, based on concentration analysis of the aggregated proteins before and after dissociation.

公开(公告)号：US20170131233A1

公开(公告)日：2017-05-11

申请号：US14994389

申请日：2016-01-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ji Yoon Kang ,  Kyeong-Sik Shin ,  Jae-hoon Ji ,  Kyoseon Hwang ,  Tae Song Kim

IPC: G01N27/416 ,  G01N33/68 ,  G01N27/327

CPC classification number: G01N27/4166 ,  G01N27/3275 ,  G01N27/745 ,  G01N33/5438

Abstract: The biosensor includes a substrate, an electrode pattern positioned on the substrate, a passivation layer which is formed with a plurality of holes spaced apart from each other, and a bead positioned at one or more holes among the plurality of holes, and to which an antibody is attached, the electrode pattern includes a first electrode pattern part and a second electrode pattern part spaced apart from the first electrode pattern part, which has a same height as a height of the first electrode pattern part, and forms an electric field with the first electrode pattern part.