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20 条记录 (耗时 0.035 秒)

    CHEMICAL SUPPRESSORS AND METHOD OF USE
    6.
    发明申请
    CHEMICAL SUPPRESSORS AND METHOD OF USE 有权
    化学抑制剂及其使用方法

    公开(公告)号：US20120141328A1

    公开(公告)日：2012-06-07

    申请号：US13368663

    申请日：2012-02-08

    申请人： Kannan SRINIVASAN ,  Christopher A. POHL

    发明人： Kannan SRINIVASAN ,  Christopher A. POHL

    IPC分类号： G01N30/02 ,  G01N30/14

    CPC分类号： G01N30/96 ,  B01D15/367 ,  B01D61/48 ,  Y10T436/25

    摘要： A non-electrolytic method and apparatus for treating an aqueous sample stream including analyte ions and matrix ions of opposite charge, for pretreatment or suppression. The apparatus includes an ion exchange membrane capable of passing only ions of opposite charge to the analyte ions, a sample stream flow channel, a first aqueous stream ion receiving flow channel adjacent one side of the sample stream flow channel and separated therefrom by the first ion exchange membrane, and stationary flow-through ion exchange packing disposed in the sample stream flow channel. The ion receiving channel has an ion exchange capacity for the matrix ions less than about 25% of the ion exchange capacity for the matrix ions.

    摘要翻译： 一种用于处理包含分析物离子和相反电荷的基质离子的水样品流的非电解方法和装置，用于预处理或抑制。 该装置包括能够仅将相反电荷的离子通过到分析物离子的离子交换膜，样品流流动通道，邻近样品流流动通道的一侧的第一含水流离子接收流动通道，并由第一离子 交换膜和设置在样品流流动通道中的固定流通离子交换填料。 离子接收通道对于基质离子的离子交换容量小于基质离子的离子交换容量的约25％。

    BUFFER KIT AND METHOD OF GENERATING A LINEAR pH GRADIENT
    7.
    发明申请
    BUFFER KIT AND METHOD OF GENERATING A LINEAR pH GRADIENT 有权
    缓冲袋和产生线性pH梯度的方法

    公开(公告)号：US20140179008A1

    公开(公告)日：2014-06-26

    申请号：US13724873

    申请日：2012-12-21

    申请人： Shanhua LIN ,  Christopher A. POHL

    发明人： Shanhua LIN ,  Christopher A. POHL

    IPC分类号： C09K15/30

    CPC分类号： C09K15/30 ,  B01D15/168 ,  B01D15/362 ,  G01N30/34 ,  Y10T436/10 ,  Y10T436/108331 ,  Y10T436/173845 ,  Y10T436/18

    摘要： A buffer kit includes a first eluent and second eluent. The first eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The second eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The first eluent solution has a first pH and the second eluent solution has a second pH where the first pH and second pH are different values. The buffer kit provides a linear pH gradient that forms an approximately straight line from at least the first pH to the second pH.

    摘要翻译： 缓冲试剂盒包括第一洗脱液和第二洗脱液。 第一洗脱溶液包括至少四种缓冲盐，其中四种缓冲盐中的至少三个是一价缓冲盐，具有净负电荷或净中性两性离子电荷，并且包括磺酸盐基和胺。 第二洗脱溶液包括至少四种缓冲盐，其中四种缓冲盐中的至少三个是单价缓冲盐，具有净负电荷或净中性两性离子电荷，并且包括磺酸盐基和胺。 第一洗脱溶液具有第一pH，第二洗脱液具有第二pH，其中第一pH和第二pH是不同的值。 缓冲试剂盒提供线性pH梯度，其从至少第一pH至第二pH形成近似的直线。

    SEPARATION OF GLYCANS BY MIXED-MODE LIQUID CHROMATOGRAPHY
    8.
    发明申请
    SEPARATION OF GLYCANS BY MIXED-MODE LIQUID CHROMATOGRAPHY 有权
    通过混合模式液相色谱法分离甘油

    公开(公告)号：US20140178912A1

    公开(公告)日：2014-06-26

    申请号：US13724178

    申请日：2012-12-21

    申请人： Xiaodong LIU ,  Udayanath AICH ,  Christopher A. POHL

    发明人： Xiaodong LIU ,  Udayanath AICH ,  Christopher A. POHL

    IPC分类号： C08B37/00 ,  B01J43/00 ,  B01J41/20

    CPC分类号： C08B37/0063 ,  B01D15/3847 ,  B01J20/286 ,  B01J20/3285 ,  B01J41/20 ,  B01J43/00 ,  B01J2220/54 ,  C07K1/165 ,  G01N30/482 ,  B01D15/363 ,  B01D15/305 ,  B01D15/325 ,  B01D15/362

    摘要： An exemplary multimodal chromatographic medium of the invention includes one or more strong anion exchange, weak anion exchange, strong cation exchange and/or weak cation exchange binding sites in combination with one or more reverse phase and/or hydrophilic interaction chromatography binding site. In an exemplary embodiment, the sites interact with one or more glycans in a mixture of glycans in a manner that allows separation of glycans in the mixture and analysis of the glycan mixture. The media are incorporated into devices and systems for chromatographic analysis. Also provided are methods of using the multimodal media of the invention to analyze glycans.

    摘要翻译： 本发明的示例性多峰色谱介质包含与一个或多个反相和/或亲水相互作用色谱结合位点结合的一个或多个强阴离子交换，弱阴离子交换，强阳离子交换和/或弱阳离子交换结合位点。 在一个示例性实施方案中，所述位点以聚糖混合物中的一种或多种聚糖与允许混合物中聚糖分离和聚糖混合物分析的方式相互作用。 将介质并入用于色谱分析的装置和系统中。 还提供了使用本发明的多峰介质来分析聚糖的方法。

    GLYCIDOL FUNCTIONALIZED ANION EXCHANGE STATIONARY PHASES
    9.
    发明申请
    GLYCIDOL FUNCTIONALIZED ANION EXCHANGE STATIONARY PHASES 有权
    甘氨酸官能化阴离子交换剂固定相

    公开(公告)号：US20140069870A1

    公开(公告)日：2014-03-13

    申请号：US13610495

    申请日：2012-09-11

    申请人： Christopher A. POHL

    发明人： Christopher A. POHL

    IPC分类号： B01J41/20 ,  B01D15/36

    CPC分类号： B01J41/20 ,  B01D15/363 ,  B01J20/288 ,  B01J20/3251 ,  B01J20/3289 ,  B01J41/09

    摘要： Treatment of anion exchange materials containing hydroxyl containing moieties in the beta position relative to the quaternary center in the hydroxide form with glycidol substantially alters the selectivity of the anion exchange material. Furthermore, sequential treatments of first a hydroxide containing solution to put the anion exchange material in the hydroxide form followed by treatment with glycidol in an alternating sequence progressively changes selectivity in a predictable manner allowing facile manipulation of selectivity. Unique to the selectivities achievable with this chemistry is the ability to reverse the elution order of sulfate and carbonate. With all other known systems, carbonate elutes ahead of sulfate and sometimes compromises the ability to quantitate sulfate. With glycidol treatment, carbonate can be moved after sulfate which eliminates interference issues for samples containing significantly more carbonate than sulfate. This modification is useful for columns operated with a hydroxide or carbonate eluent system.

    摘要翻译： 含有羟基的阴离子交换材料相对于具有缩水甘油的氢氧化物形式的季中心的β位置的处理基本上改变了阴离子交换材料的选择性。 此外，首先连续处理含氢氧化物溶液以将阴离子交换材料置于氢氧化物形式，然后以交替的顺序用缩水甘油处理，以可预测的方式逐渐改变选择性，从而容易地操纵选择性。 通过该化学可以实现的选择性独特的是反转硫酸盐和碳酸盐的洗脱顺序的能力。 使用所有其他已知的系统，碳酸盐在硫酸盐之前洗脱，有时会损害硫酸盐的定量能力。 通过缩水甘油处理，碳酸盐可以在硫酸盐之后移动，消除了含有比硫酸盐显着更多的碳酸盐的样品的干扰问题。 该修饰对于用氢氧化物或碳酸盐洗脱液系统操作的柱是有用的。