利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.054 秒)

    Oxadiazolidinedione Compound
    3.
    发明申请
    Oxadiazolidinedione Compound 有权
    恶二唑烷二酮化合物

    公开(公告)号：US20090186909A1

    公开(公告)日：2009-07-23

    申请号：US12298522

    申请日：2007-04-23

    申请人： Kenji Negoro ,  Fumiyoshi Iwasaki ,  Kei Ohnuki ,  Toshio Kurosaki ,  Yasuhiro Yonetoku ,  Norio Asai ,  Shigeru Yoshida ,  Takatoshi Soga

    发明人： Kenji Negoro ,  Fumiyoshi Iwasaki ,  Kei Ohnuki ,  Toshio Kurosaki ,  Yasuhiro Yonetoku ,  Norio Asai ,  Shigeru Yoshida ,  Takatoshi Soga

    IPC分类号： A61K31/506 ,  A61K31/4439 ,  A61K31/4245 ,  C07D413/12 ,  C07D271/07

    CPC分类号： C07D271/06 ,  C07D271/07 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

    摘要： [Problem] A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided.[Means for resolution] It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.

    摘要翻译： 可以提供可用作药物的化合物，特别是胰岛素分泌促进剂或用于预防/治疗其中涉及GPR40的疾病如糖尿病等的化合物。 [解决方法]已经发现，恶二唑烷二酮化合物或其药学上可接受的盐，其特征在于具有通过在恶二唑烷二酮环的2位上的连接基与环状基团结合的苄基等取代基， 具有优异的GPR40激动作用。 此外，由于本发明的恶二唑烷二酮化合物显示出优异的胰岛素分泌促进作用和血糖降低作用，因此可用作胰岛素分泌促进剂或糖尿病的预防/治疗剂。

    OXADIAZOLIDINEDIONE COMPOUND
    4.
    发明申请
    OXADIAZOLIDINEDIONE COMPOUND 审中-公开
    氧化杂环化合物

    公开(公告)号：US20100267775A1

    公开(公告)日：2010-10-21

    申请号：US12739501

    申请日：2008-10-22

    申请人： Kenji Negoro ,  Fumiyoshi Iwasaki ,  Kei Ohnuki ,  Toshio Kurosaki ,  Kazuyuki Tsuchiya ,  Kazuyuki Kuramoto ,  Shigeru Yoshida ,  Takatoshi Soga

    发明人： Kenji Negoro ,  Fumiyoshi Iwasaki ,  Kei Ohnuki ,  Toshio Kurosaki ,  Kazuyuki Tsuchiya ,  Kazuyuki Kuramoto ,  Shigeru Yoshida ,  Takatoshi Soga

    IPC分类号： A61K31/4439 ,  C07D271/07 ,  A61K31/4245 ,  A61P3/10 ,  C07D413/12

    CPC分类号： C07D271/06 ,  C07D271/07 ,  C07D413/12

    摘要： A pharmaceutical agent having GPR40 receptor agonistic action, particularly a compound which is useful as an insulin secretagogue or an agent for preventing and/or treating diabetes mellitus. The present inventors have examined a compound having GPR40 receptor agonistic action, confirmed that an oxadiazolidinedione compound which has a substituent such as a benzyl group, etc. linked with a substituent such as a phenyl group, etc. through a linker at the 2-position of an oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof has an excellent GPR40 agonistic activity, and thus completed the invention. The oxadiazolidinedione compound has excellent insulin secretagogue action and anti-hyperglycemic action, and therefore can be used as an insulin secretagogue or an agent for preventing and/or treating diabetes mellitus.

    摘要翻译： 具有GPR40受体激动作用的药剂，特别是可用作胰岛素促分泌剂的化合物或用于预防和/或治疗糖尿病的药剂。 本发明人已经研究了具有GPR40受体激动作用的化合物，证实了通过2-位的连接基与诸如苯基等取代基连接的具有苄基等取代基的恶二唑烷二酮化合物等 的恶二唑烷二酮环或其药学上可接受的盐具有优异的GPR40激动活性，从而完成了本发明。 恶二唑烷二酮化合物具有优异的胰岛素促分泌作用和抗高血糖作用，因此可用作胰岛素促分泌素或预防和/或治疗糖尿病的药剂。