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    Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor
    2.
    发明授权
    Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor 失效
    判断白血病，白血病前或白血病恶性血液病的诊断方法

    公开(公告)号：US07479371B2

    公开(公告)日：2009-01-20

    申请号：US10510627

    申请日：2003-04-09

    申请人： Kiyoshi Ando ,  Tomomitsu Hotta ,  Chie Ito ,  Hidenao Sato ,  Akiko Furuya ,  Kenya Shitara ,  Seiji Sugimoto ,  Hiroaki Kohno

    发明人： Kiyoshi Ando ,  Tomomitsu Hotta ,  Chie Ito ,  Hidenao Sato ,  Akiko Furuya ,  Kenya Shitara ,  Seiji Sugimoto ,  Hiroaki Kohno

    IPC分类号： G01N33/53 ,  C07K16/00

    CPC分类号： C07K16/22 ,  G01N33/57426 ,  G01N2333/475

    摘要： The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells, and a method of diagnosing the graft versus host disease, each of said methods comprising quantifying stem cell growth factor (SCGF). The present invention also makes it possible to provide an agent for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases and an agent for diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells or an agent for diagnosing graft versus host disease (GVHD), each containing as an active ingredient an antibody reacting with stem cell growth factor (SCGF).

    摘要翻译： 本发明涉及白血病，白血病前或白血病恶性血液病诊断方法，白血病与白血病前白血病恶性血液疾病的鉴别方法，再生障碍性贫血与骨髓增生异常综合征的鉴别方法，延迟诊断方法 造血干细胞移植后造血干细胞的移植，以及诊断移植物抗宿主病的方法，每种方法包括量化干细胞生长因子（SCGF）。 本发明还可以提供用于诊断白血病，白血病前或白血病恶性血液病的药剂和用于诊断造血干细胞移植后的造血干细胞的延迟植入或用于诊断移植物与宿主的试剂的试剂 疾病（GVHD），各自含有与干细胞生长因子（SCGF）反应的抗体作为活性成分。

    PROCESS FOR PRODUCING POLYPEPTIDE
    3.
    发明申请
    PROCESS FOR PRODUCING POLYPEPTIDE 有权
    生产多肽的方法

    公开(公告)号：US20090203078A1

    公开(公告)日：2009-08-13

    申请号：US12364049

    申请日：2009-02-02

    申请人： Tatsuya OGAWA ,  Yoshinobu Konno ,  Naohisa Akashi ,  Hiroshi Takasugi ,  Seiji Sugimoto ,  Keiichi Yano

    发明人： Tatsuya OGAWA ,  Yoshinobu Konno ,  Naohisa Akashi ,  Hiroshi Takasugi ,  Seiji Sugimoto ,  Keiichi Yano

    IPC分类号： C12P21/00 ,  C12N5/06

    CPC分类号： C07K16/00

    摘要： The present invention relates to a process for producing a desired polypeptide using rat cells. Specifically, the present invention relates to a process for producing the polypeptide which comprises culturing rat cells such as YB2/3HL.P2.G11.16Ag.20 (hereinafter referred to as YB2/0), preferably rat cells to which a recombinant DNA comprising DNA encoding a desired polypeptide such as an immunologically functional molecule is introduced, in a medium which does not contain serum (hereinafter referred to as a serum-free medium). Among the desired polypeptides obtained by the process of the present invention, an antibody obtained by using a transformant of YB2/0 has a high antibody-dependent cell-mediated cytotoxic activity (hereinafter sometimes referred to as ADCC activity) and is useful as a pharmaceutical agent.

    摘要翻译： 本发明涉及使用大鼠细胞产生所需多肽的方法。 具体而言，本发明涉及多肽的制造方法，其包括培养大鼠细胞如YB2 / 3HL.P2.G11.16Ag.20（以下称为YB2 / 0），优选大鼠细胞，其中重组DNA包含 在不含血清的培养基（以下称为无血清培养基）中，导入编码所需多肽如免疫功能性分子的DNA。 在通过本发明的方法获得的所需多肽中，通过使用YB2 / 0的转化体获得的抗体具有高抗体依赖性细胞介导的细胞毒活性（以下有时称为ADCC活性），并且可用作药物 代理商

    Process for producing polypeptide
    4.
    发明授权
    Process for producing polypeptide 有权
    生产多肽的方法

    公开(公告)号：US07504256B1

    公开(公告)日：2009-03-17

    申请号：US10110997

    申请日：2000-10-19

    申请人： Tatsuya Ogawa ,  Yoshinobu Konno ,  Naohisa Akashi ,  Hiroshi Takasugi ,  Seiji Sugimoto ,  Keiichi Yano

    发明人： Tatsuya Ogawa ,  Yoshinobu Konno ,  Naohisa Akashi ,  Hiroshi Takasugi ,  Seiji Sugimoto ,  Keiichi Yano

    IPC分类号： C12N5/06 ,  C12N5/12 ,  C12N5/16

    CPC分类号： C07K16/00

    摘要： The present invention relates to a process for producing a desired polypeptide using rat cells. Specifically, the present invention relates to a process for producing the polypeptide which comprises culturing rat cells such as YB2/3HL.P2.G11.16Ag.20 (hereinafter referred to as YB2/0), preferably rat cells to which a recombinant DNA comprising DNA encoding a desired polypeptide such as an immunologically functional molecule is introduced, in a medium which does not contain serum (hereinafter referred to as a serum-free medium). Among the desired polypeptides obtained by the process of the present invention, an antibody obtained by using a transformant of YB2/0 has a high antibody-dependent cell-mediated cytotoxic activity (hereinafter sometimes referred to as ADCC activity) and is useful as a pharmaceutical agent.

    摘要翻译： 本发明涉及使用大鼠细胞产生所需多肽的方法。 具体而言，本发明涉及多肽的制造方法，其包括培养大鼠细胞如YB2 / 3HL.P2.G11.16Ag.20（以下称为YB2 / 0），优选大鼠细胞，其中重组DNA包含 在不含血清的培养基（以下称为无血清培养基）中，导入编码所需多肽如免疫功能性分子的DNA。 在通过本发明的方法获得的所需多肽中，通过使用YB2 / 0的转化体获得的抗体具有高抗体依赖性细胞介导的细胞毒活性（以下有时称为ADCC活性），并且可用作药物 代理商

    Epitaxial film growing method, wafer supporting structure and susceptor
    6.
    发明授权
    Epitaxial film growing method, wafer supporting structure and susceptor 有权
    外延膜生长方法，晶片支撑结构和基座

    公开(公告)号：US08324063B2

    公开(公告)日：2012-12-04

    申请号：US12682850

    申请日：2008-11-06

    申请人： Takashi Fujikawa ,  Seiji Sugimoto

    发明人： Takashi Fujikawa ,  Seiji Sugimoto

    IPC分类号： H01L21/331

    CPC分类号： H01L21/68735 ,  C23C16/4585 ,  C30B25/12

    摘要： An annular step portion provided to a periphery of a wafer housing portion is provided to an area with which an area of 1 to 6 mm from a boundary line with a chamfered surface of a wafer rear surface toward a wafer center comes in contact. As a result, it is possible to produce an epitaxial wafer having no scratch in a boundary area between the rear surface and the chamfered surface, and to eliminate particles generated due to a scratch in a device process.

    摘要翻译： 设置在晶片收纳部周边的环状台阶部设置在与晶片背面朝向晶片中心的倒角表面的边界线1〜6mm的面积接触的区域。 结果，可以在后表面和倒角表面之间的边界区域中制造没有划痕的外延晶片，并且消除在器件工艺中由划痕产生的微粒。

    METHOD FOR HOLDING SILICON WAFER
    7.
    发明申请
    METHOD FOR HOLDING SILICON WAFER 审中-公开
    保持硅波的方法

    公开(公告)号：US20090304490A1

    公开(公告)日：2009-12-10

    申请号：US12135805

    申请日：2008-06-09

    申请人： Takayuki Kihara ,  Masataka Hourai ,  Yuki Murata ,  Kazushige Takaishi ,  Seiji Sugimoto ,  Tadashi Kanda

    发明人： Takayuki Kihara ,  Masataka Hourai ,  Yuki Murata ,  Kazushige Takaishi ,  Seiji Sugimoto ,  Tadashi Kanda

    IPC分类号： H01L21/67

    CPC分类号： H01L21/6732

    摘要： The present invention is directed to provide a method for holding a silicon wafer, which can reduce contact scratches in contact with support members when holding a back surface of the silicon wafer, as well as prevent the wafer from bending when holding the back surface of the silicon wafer. The back surface of a silicon wafer of 300 millimeters or more in diameter and 700 micrometers to 1000 micrometers in thickness is held in contact with a support member or a suction member, specifically held within a region where a radius of the silicon wafer×0.50 to 0.80 from a center thereof. The silicon wafer is held in a state where the maximum amount of displacement within a wafer plane is 300 micrometers or less. The silicon wafer back surface is held in contact within the holding region in all the processes of holding the back surface of the silicon wafer in contact with the support member or the suction member.

    摘要翻译： 本发明的目的在于提供一种保持硅晶片的方法，当保持硅晶片的背面时，可以减少与支撑部件接触的接触划痕，并且当保持硅晶片的背面时，防止晶片弯曲 硅晶片。 直径为300毫米，厚度为700微米至1000微米的硅晶片的背面保持与支撑构件或抽吸构件接触，特别是保持在硅晶片的半径为0.50至 0.80从其中心。 硅晶片保持在晶片平面内的最大位移量为300微米以下的状态。 在保持硅晶片的背面与支撑构件或抽吸构件接触的所有过程中，硅晶片背面保持在保持区域内。

    Phytase having a low Michaelis constant for phytic acid from monascus
    8.
    发明授权
    Phytase having a low Michaelis constant for phytic acid from monascus 失效
    植酸酶对于红曲霉植酸具有较低的米氏常数

    公开(公告)号：US06372247B1

    公开(公告)日：2002-04-16

    申请号：US09885932

    申请日：2001-06-22

    申请人： Tadashi Nagashima ,  Satoshi Kuroyanagi ,  Tadanori Yamamura ,  Hideharu Anazawa ,  Yoko Kato ,  Seiji Sugimoto ,  Keiichi Yano

    发明人： Tadashi Nagashima ,  Satoshi Kuroyanagi ,  Tadanori Yamamura ,  Hideharu Anazawa ,  Yoko Kato ,  Seiji Sugimoto ,  Keiichi Yano

    IPC分类号： A23K1165

    CPC分类号： C12N9/16 ,  A23K20/189 ,  Y10S426/807

    摘要： Provided is an isolated phytase derived from a microorganism. The microorganism is preferably from the genus Monascus. The phytase has a Michaelis constant of 10 to 110 &mgr;M when phytic acid is used as a substrate. A process for producing the phytase is also provided as is an animal feed comprising the phytase. The phytase is preferably isolated from Monascus anka IFO 30873. The phytase has a Km of 107 &mgr;m when phytic acid is used as a substrate, the optimum pH is 2.5, the optimum temperature is 45° C., the molecular weight of the phytase is 140 kDa when measured by gel filtration, and the isolectric point is 5.2 using chromatofocusing.

    摘要翻译： 提供来自微生物的分离的植酸酶。 微生物优选来自红曲霉属。 当植酸作为底物时，植酸酶的米氏常数为10〜110μM。 还提供了用于产生植酸酶的方法，包括植酸酶的动物饲料也是如此。 植酸酶优选与红曲霉IFO 30873分离。当植酸用作底物时，肌醇六磷酸酶的Km为107，最佳pH为2.5，最适温度为45℃，植酸酶的分子量为 当通过凝胶过滤测量时为140kDa，并且使用色谱聚焦的等电点为5.2。

    Polysaccharide and a method of producing it
    10.
    发明授权
    Polysaccharide and a method of producing it 失效
    多糖及其生产方法

    公开(公告)号：US5378832A

    公开(公告)日：1995-01-03

    申请号：US94091

    申请日：1993-07-20

    申请人： Ryuichiro Kurane ,  Yasuhiro Nohata ,  Michio Shiomi ,  Shuichi Ishino ,  Akira Yotsuji ,  Hideki Murata ,  Seiji Sugimoto

    发明人： Ryuichiro Kurane ,  Yasuhiro Nohata ,  Michio Shiomi ,  Shuichi Ishino ,  Akira Yotsuji ,  Hideki Murata ,  Seiji Sugimoto

    IPC分类号： B01F17/56 ,  C08B37/00 ,  C12P19/04 ,  C12N1/20

    CPC分类号： C12P19/04 ,  C08B37/006 ,  Y10S435/829

    摘要： The present invention provides a polymer comprising a polysaccharide having excellent water absorption properties, moisture absorption properties, moisture retention properties and thickening properties. Said polysaccharide has the following properties: (A) the principal constituents of the sugar composition are rhamnose, fucose, glucose and glucuronic acid which are present in a molar ratio of (1-4):2:(1-8):(1-4); (B) elemental analysis (wt %):C: 36 .+-.3H: 7 .+-.1O: 56 .+-.4,containing 9-13% of crystalline water(C) solubility:slightly soluble in water; soluble in alkalies; insoluble in methanol, ethanol and acetone;(D) UV absorption spectrum:no absorption detected at 280 nm characteristic of proteins (peptides) or at 260 nm characteristic of nucleic acids; and(E) IR absorption spectrum:an absorption pattern characteristic of polysaccharides is observed near 800-1200.sup.-iSaid polysaccharide is produced by a fermentation method using a natural medium or a synthetic medium of Alcaligenes microorganism.

    摘要翻译： PCT No.PCT / JP92 / 00695 Sec。 371日期：1993年7月20日 102（e）日期1993年7月20日PCT提交1993年7月20日PCT公布。 公开号WO93 / 11163 日期：6月10日，1993。本发明提供了包含具有优异的吸水性，吸湿性，保湿性和增稠性的多糖的聚合物。 所述多糖具有以下性质：（A）糖组合物的主要成分是以（1-4）：2：（1-8）：（1）的摩尔比存在的鼠李糖，岩藻糖，葡萄糖和葡萄糖醛酸 -4）; （B）元素分析（重量％）：C：36 +/- 3 H：7 +/- 1 O：56 +/- 4，含有9-13％的结晶水（C）溶解度：微溶于水; 溶于碱; 不溶于甲醇，乙醇和丙酮; （D）紫外线吸收光谱：蛋白质（肽）的特征性或280nm特征性的核酸在280nm处未检测到吸收; 和（E）IR吸收光谱：在800-1200-i附近观察到多糖的吸收图案特征。所述多糖通过使用天然培养基或产碱杆菌微生物的合成培养基的发酵方法产生。