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公开(公告)号：US12061189B2
公开(公告)日：2024-08-13
申请号：US16624087
申请日：2018-06-21
Applicant: Laboratoires Expanscience
Inventor： Gaelle Bellemere , Stephanie Bredif , Gaetan Boyer , Caroline Baudouin
CPC classification number: G01N33/5088 , C12N5/0698 , C12N2503/06
Abstract: The present invention relates to models of reconstructed sensitive skin reproducing the features of sensitive skin, as well as to processes for obtaining such models. The present invention further relates to in vitro processes for testing formulations or active ingredients for the prevention or treatment of sensitive skin.
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公开(公告)号：US10143648B2
公开(公告)日：2018-12-04
申请号：US15529694
申请日：2015-11-26
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Caroline Baudouin , Stéphanie Bredif
Abstract: The present invention relates to the use of a peptide and glycoside extract of Schizandra fruit as a cutaneous neurosensory agent, for improving the response of the cutaneous neurosensory system, in particular for: —improving cutaneous innervation in the basal state, —combatting age-related loss of cutaneous innervation in the basal state, advantageously for preventing loss of the cutaneous sensitivity and/or combatting thinning of the epidermis, and/or —improving cutaneous perception of the environment, more particularly for combatting burns, extreme cold and/or pain.
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公开(公告)号：US20170241989A1
公开(公告)日：2017-08-24
申请号：US15128717
申请日：2015-03-31
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline Baudouin
CPC classification number: G01N33/5088 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/6881 , G01N2500/04 , G01N2500/10
Abstract: The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skin's response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.
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公开(公告)号：US09616009B2
公开(公告)日：2017-04-11
申请号：US14514646
申请日：2014-10-15
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline Baudouin , Philippe Msika
IPC: A61K8/60 , A61K8/97 , A61K9/48 , A61K31/70 , A61K31/7004 , A61K36/54 , A61K45/06 , A61Q3/00 , A61Q7/00 , A23L2/52 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A23L7/126 , A61Q5/00
CPC classification number: A61K8/60 , A23L2/52 , A23L7/126 , A23V2002/00 , A61K8/97 , A61K9/4858 , A61K31/70 , A61K31/7004 , A61K36/54 , A61K45/06 , A61K2800/5922 , A61K2800/92 , A61Q3/00 , A61Q5/00 , A61Q5/006 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q7/00 , A61K2300/00
Abstract: The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.
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公开(公告)号：US20160195515A1
公开(公告)日：2016-07-07
申请号：US14915702
申请日：2014-09-03
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Nadege Lachmann , Caroline Baudouin
CPC classification number: G01N33/5044 , G01N33/5023 , G01N33/6881 , G01N2333/47
Abstract: The present invention thus relates to a method for determining the degree of maturation of the skin surface of a subject. In particular, the present invention relates to method for determining whether the skin surface of a subject is mature/immature in its organization/function, said method comprising the steps of taking a skin sample of the said subject; and determining the corneodesmosome distribution within the stratum corneum of the sample.
Abstract translation: 因此，本发明涉及一种用于确定受试者的皮肤表面的成熟程度的方法。 特别地，本发明涉及用于确定受试者的皮肤表面在其组织/功能中是否成熟/不成熟的方法，所述方法包括以下步骤：摄取所述受试者的皮肤样品; 并测定样品角质层内的角质层分布。
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Patent Agency Ranking
公开(公告)号：US20150285787A1
公开(公告)日：2015-10-08
申请号：US14414253
申请日：2013-07-15
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Caroline Baudouin
CPC classification number: G01N33/5044 , C12Q1/6876 , C12Q1/6888 , C12Q2600/148 , C12Q2600/158 , G01N33/5088 , G01N33/6881 , G01N33/6893 , G01N33/92 , G01N2800/20 , G01N2800/60
Abstract: The present invention relates to a method for identifying biological markers for characterizing children's skin. The method of the invention thus makes it possible to identify molecular markers that are expressed differently in children's skin than in the skin of adults. The present invention therefore enables the skin to be characterized at the molecular level from birth and the changes thereof with age to be tracked.
Abstract translation: 本发明涉及用于鉴定表征儿童皮肤的生物标志物的方法。 因此，本发明的方法使得可以鉴定在儿童皮肤中不同于在成人皮肤中表达的分子标记。 因此，本发明能够使皮肤在出生时的分子水平和随着年龄的变化被跟踪。
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公开(公告)号：US10196607B2
公开(公告)日：2019-02-05
申请号：US15110826
申请日：2015-01-12
Applicant: Laboratoires Expanscience
Inventor： Stephanie Bredif , Caroline Baudouin , Philippe Msika , Marisa Meloni
Abstract: A skin model comprises keratinocytes capable of overexpressing filaggrin. A method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, by bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion, and measuring the level of production of at least one biological marker chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin.
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公开(公告)号：US20160245795A1
公开(公告)日：2016-08-25
申请号：US15023882
申请日：2014-09-24
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Caroline Baudouin , Stephanie Bredif , Philippe MSIKA
CPC classification number: G01N33/5023 , G01N33/5044 , G01N33/6881 , G01N2333/4721 , G01N2333/5421 , G01N2333/545 , G01N2333/96486
Abstract: The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.
Abstract translation: 本发明涉及用于测试制剂或活性成分以防止紫外线对儿童皮肤，特别是三岁以下儿童的有害影响的体外方法。 本发明人已经开发了使用特别能够再现这种年龄的儿童的皮肤特征的皮肤模型来评价制剂在体外预防紫外线对三岁以下儿童皮肤的有害影响的体外功效的方法。
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9.发明申请USE OF A COMPOSITION COMPRISING AVOCADO PERSEOSE IN THE PROTECTION OF EPIDERMAL STEM CELLS 审中-公开使用包含AVOCADO相关物质在保护皮肤干细胞中的组合物公开(公告)号：US20150374605A1
公开(公告)日：2015-12-31
申请号：US14766602
申请日：2014-02-11
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Philippe Msika , Caroline Baudouin
CPC classification number: A61K8/60 , A61K8/97 , A61K31/22 , A61K31/23 , A61K31/232 , A61K31/7012 , A61K31/7024 , A61K36/54 , A61K45/06 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/005 , A61Q19/08 , A61Q19/10 , C07C69/02 , C07C69/52 , C07C69/533 , C07C69/587 , A61K2300/00
Abstract: The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.
Abstract translation: 本发明涉及C7糖和式（I）的衍生物，其被称为鳄梨坚果，其特别地对表皮皮肤细胞具有保护性活性。 这些C7糖和衍生物能够维持成体干细胞，特别是基础干细胞的标志物的表达。 鳄梨坚果也可用于防止环境破坏的有害影响。 鳄梨坚果对保护表皮干细胞的潜力有益，从而有助于维持皮肤稳态。
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公开(公告)号：US12109245B2
公开(公告)日：2024-10-08
申请号：US16580826
申请日：2019-09-24
Applicant: LABORATOIRES EXPANSCIENCE
Inventor： Alex Saunois , Caroline Baudouin , Sophie Leclere-Bienfait , Sebastien Garnier , Philippe Msika
IPC: A61K8/49 , A23L33/105 , A61K8/368 , A61K8/9789 , A61K31/05 , A61K31/197 , A61K31/198 , A61K31/201 , A61K31/341 , A61K31/42 , A61K31/57 , A61K31/585 , A61K31/715 , A61K31/717 , A61K33/30 , A61K36/28 , A61K36/31 , A61K36/48 , A61K36/54 , A61K36/899 , A61K38/00 , A61K45/00 , A61Q19/08
CPC classification number: A61K36/31 , A23L33/105 , A61K8/368 , A61K8/498 , A61K8/9789 , A61K31/05 , A61K31/197 , A61K31/198 , A61K31/201 , A61K31/341 , A61K31/42 , A61K31/57 , A61K31/585 , A61K31/715 , A61K31/717 , A61K33/30 , A61K36/28 , A61K36/48 , A61K36/54 , A61K36/899 , A61K38/00 , A61K45/00 , A61Q19/08 , A61K2800/805
Abstract: The invention relates to an extract of aerial parts of Maca rich in polyphenols, and also to a composition comprising such an extract and, where appropriate, a suitable excipient. The invention also relates to a process for extracting an extract of aerial parts of Maca rich in polyphenols, and also to the extract that can be obtained by means of said process. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths and/or for use thereof in preventing and/or treating vascular disorders. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which comprises the administration of such a composition or of such an extract.
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