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公开(公告)号：US20240101999A1
公开(公告)日：2024-03-28
申请号：US18235205
申请日：2023-08-17
Applicant: Thermo Fisher Scientific GENEART GmbH , LIFE TECHNOLOGIES AS , LIFE TECHNOLOGIES CORPORATION
Inventor： Thomas POEHMERER , Phillip KUHN , Frank NOTKA , Andreas ZEIDLER , Korbinian HEIL , Axel TREFZER , Geir FONNUM , Federico KATZEN , Kristian ANDERSSON , Xiquan LIANG
CPC classification number: C12N15/101 , B01L3/502761 , B03C5/026 , C25B3/29 , C25B9/70 , C25B11/04 , C25B15/02 , B01J2219/00468 , B01J2219/005 , B01J2219/00653 , B01J2219/00695 , B01J2219/00722 , B01L3/502715 , B01L2200/0642 , B01L2200/0647 , B01L2300/0819 , B01L2300/0893 , B01L2400/046 , B01L2400/0487 , B03C2201/26
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US20180245116A1
公开(公告)日：2018-08-30
申请号：US15873477
申请日：2018-01-17
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Xiquan LIANG , Chang-Ho BAEK , Lansha PENG , Federico KATZEN
CPC classification number: C12P19/34 , C12N15/10 , C12N15/1031 , C12N15/64 , C12N15/66
Abstract: The present disclosure generally relates to compositions and methods for the assembly of nucleic acid molecules into larger nucleic acid molecules. Also provided are compositions and methods for seamlessly connection of nucleic acid molecules with high sequence fidelity.
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3.发明申请TAL-EFFECTOR ASSEMBLY PLATFORM, CUSTOMIZED SERVICES, KITS AND ASSAYS 审中-公开TAL-EFFECTOR组装平台，定制服务，套件和测试公开(公告)号：US20130274129A1
公开(公告)日：2013-10-17
申请号：US13856978
申请日：2013-04-04
Applicant: GENEART AG , LIFE TECHNOLOGIES CORPORATION
Inventor： Federico KATZEN , Jonathan Chesnut , Frank Notka , Matthias Arnold , Kevin Hoff , Stephen Whiteside
IPC: C07K14/195 , C12N15/66 , C12N15/10
CPC classification number: C12N15/1082 , C07K14/195 , C12N9/90 , C12N9/96 , C12N15/102 , C12N15/1086 , C12N15/1093 , C12N15/66 , C12Y599/01002
Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.
Abstract translation: 本发明一般涉及用于设计和产生功能性DNA结合效应分子和相关定制服务，工具包和功能测定的组合物和方法。 在一些方面，本发明提供了用于有效组装定制的TAL效应分子的方法和工具。 此外，本发明涉及TAL效应分子的用途和通过例如定制测定法对这种TAL的功能评估。
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Patent Agency Ranking
公开(公告)号：US20210047636A1
公开(公告)日：2021-02-18
申请号：US16915834
申请日：2020-06-29
Inventor： Federico KATZEN , Jonathan CHESNUT , Frank NOTKA , Matthias ARNOLD , Kevin HOFF , Stephen WHITESIDE
IPC: C12N15/10 , C07K14/195 , C12N15/66 , C12N9/90 , C12N9/96
Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.
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公开(公告)号：US20200325514A1
公开(公告)日：2020-10-15
申请号：US16736258
申请日：2020-01-07
Inventor： Todd PETERSON , Axel TREFZER , Thomas POEHMERER , Federico KATZEN , Xiquan LIANG
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US20190112596A1
公开(公告)日：2019-04-18
申请号：US15951938
申请日：2018-04-12
Inventor： Federico KATZEN , Jonathan CHESTNUT , Frank NOTKA , Matthias Arnold , Kevin HOFF , Stephen WHITESIDE
IPC: C12N15/10 , C12N9/96 , C12N9/90 , C07K14/195 , C12N15/66
CPC classification number: C12N15/1082 , C07K14/195 , C12N9/90 , C12N9/96 , C12N15/102 , C12N15/1086 , C12N15/1093 , C12N15/66 , C12Y599/01002
Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.
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公开(公告)号：US20160264962A1
公开(公告)日：2016-09-15
申请号：US14811363
申请日：2015-07-28
Applicant: Life Technologies Corporation , GeneArt Ag
Inventor： Federico KATZEN , Jonathan Chesnut , Frank Notka , Matthias Arnold , Kevin Hoff , Stephen Whiteside
IPC: C12N15/10 , C12N9/90 , C07K14/195 , C12N9/96
CPC classification number: C12N15/1082 , C07K14/195 , C12N9/90 , C12N9/96 , C12N15/102 , C12N15/1086 , C12N15/1093 , C12N15/66 , C12Y599/01002
Abstract: The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.
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公开(公告)号：US20160122792A1
公开(公告)日：2016-05-05
申请号：US14775648
申请日：2014-03-14
Inventor： Todd PETERSON , Axel TREFZER , Thomas POEHMERER , Federico KATZEN , Xiquan LIANG
IPC: C12P19/34
CPC classification number: C12P19/34 , C12N15/1031 , C12N15/1093
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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