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1.发明申请Synthesis Of 2' , 3' -Dideoxynucleosides For Automated DNA Synthesis And Pyrophosphorolysis Activated Polymerization 有权用于自动DNA合成和焦磷酸分解活化聚合的2'，3'-二脱氧核苷的合成公开(公告)号：US20150045547A1
公开(公告)日：2015-02-12
申请号：US14173725
申请日：2014-02-05
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Zhaochun MA , Khairuzzaman Bashar Mullah , Robert Eason
CPC classification number: C07H19/16 , C07D239/54 , C07D405/04 , C07D473/18 , C07D473/34 , C07H19/06 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/6806
Abstract: Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.
Abstract translation: 公开了制备2'，3'-二脱氧核苷酸支持结构的方法，例如2'，3'-二脱氧鸟苷，2'，3'-二脱氧腺苷和3'-脱氧胸苷支持结构。 还提供了使用这些结构的各种方法，例如其用于自动DNA合成和焦磷酸裂解活化聚合的用途。
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公开(公告)号：US09417233B2
公开(公告)日：2016-08-16
申请号：US14602619
申请日：2015-01-22
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Aldrich Lau , Robert Eason , Maxim Brevnov , Handong Li , Kevin Hacker
IPC: C12Q1/70 , C12Q1/68 , G01N33/543 , C12N1/02 , G01N33/569 , C12N13/00
CPC classification number: G01N33/54326 , C12N1/02 , C12N13/00 , C12Q1/689 , G01N33/54353 , G01N33/56911
Abstract: Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.
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3.发明授权Synthesis of 2′, 3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization 有权用于自动DNA合成和焦磷酸裂解活化聚合的2'，3'-双脱氧核苷合成公开(公告)号：US09228227B2
公开(公告)日：2016-01-05
申请号：US14173725
申请日：2014-02-05
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Zhaochun Ma , Khairuzzaman Bashar Mullah , Robert Eason
IPC: C07D473/18 , C12Q1/68 , C07D405/04 , C07D473/34 , C07H19/16 , C07D239/54 , C07H19/06 , C07H21/00 , C07H21/02 , C07H21/04
CPC classification number: C07H19/16 , C07D239/54 , C07D405/04 , C07D473/18 , C07D473/34 , C07H19/06 , C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/6806
Abstract: Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.
Abstract translation: 公开了制备2'，3'-二脱氧核苷酸支持结构的方法，例如2'，3'-二脱氧鸟苷，2'，3'-二脱氧腺苷和3'-脱氧胸苷支持结构。 还提供了使用这些结构的各种方法，例如其用于自动DNA合成和焦磷酸裂解活化聚合的用途。
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公开(公告)号：US20150197743A1
公开(公告)日：2015-07-16
申请号：US14602619
申请日：2015-01-22
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Aldrich Lau , Robert Eason , Maxim Brevnov , Handong Li , Kevin Hacker
CPC classification number: G01N33/54326 , C12N1/02 , C12N13/00 , C12Q1/689 , G01N33/54353 , G01N33/56911
Abstract: Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.
Abstract translation: 描述包括包含各种碳水化合物的多价配体的磁珠。 还提供了制备这种磁珠的方法以及它们用于捕获和富集病原体细胞群以用于随后的培养，裂解和鉴定的方法。
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