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    Implants based on bipolar metal oxide semiconductor (MOS) electronics
    1.
    发明授权
    Implants based on bipolar metal oxide semiconductor (MOS) electronics 失效
    基于双极金属氧化物半导体（MOS）电子学的植入物

    公开(公告)号：US07831309B1

    公开(公告)日：2010-11-09

    申请号：US11951955

    申请日：2007-12-06

    Applicant: Mark Humayun ,  Howard Phillips

    Inventor： Mark Humayun ,  Howard Phillips

    IPC: A61N1/00

    CPC classification number: A61N1/36046 ,  A61N1/0543

    Abstract: Intraocular and periocular implantation devices based on one or more implantation electronic chips for implantation within the eye to include a bipolar MOS circuit that is DC biased at or near a natural electrical ground potential of the eye. Described examples include retinal prosthesis devices and techniques that use bipolar MOS electronics.

    Abstract translation: 基于用于植入眼睛内的一个或多个注入电子芯片的眼内和眼周植入装置，以包括被偏置在眼睛的自然电接地电位处或其附近的直流偏压的双极MOS电路。 所描述的实例包括使用双极MOS电子器件的视网膜假体装置和技术。

    Flexible circuit electrode array
    2.
    发明授权
    Flexible circuit electrode array 有权

    公开(公告)号：US10667404B2

    公开(公告)日：2020-05-26

    申请号：US11926046

    申请日：2007-10-28

    Applicant: Robert Greenberg ,  Neil Talbot ,  Jordan Neysmith ,  Dilek Guven ,  James Little ,  Brian Mech ,  Mark Humayun

    Inventor： Robert Greenberg ,  Neil Talbot ,  Jordan Neysmith ,  Dilek Guven ,  James Little ,  Brian Mech ,  Mark Humayun

    IPC: A61N1/05 ,  H05K3/00 ,  A61N1/36

    Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

    INSTRUMENT AND METHODS FOR FILLING AN IMPLANTED DRUG PUMP
    8.
    发明申请
    INSTRUMENT AND METHODS FOR FILLING AN IMPLANTED DRUG PUMP 审中-公开
    用于填充植入式药液泵的仪器和方法

    公开(公告)号：US20120234433A1

    公开(公告)日：2012-09-20

    申请号：US13419968

    申请日：2012-03-14

    Applicant: Jason Shih ,  Sean Caffey ,  Mark Humayun ,  Fukang Jiang ,  Changlin Pang ,  Raymond Peck ,  Yu-Chong Tai

    Inventor： Jason Shih ,  Sean Caffey ,  Mark Humayun ,  Fukang Jiang ,  Changlin Pang ,  Raymond Peck ,  Yu-Chong Tai

    IPC: B65B31/00

    CPC classification number: A61M5/14276

    Abstract: A tool for refilling an implantable pump having at least one reservoir. The tool includes a plurality of independent fluid channels; a fluid reservoir in fluid communication with a first one of the fluid channels; at least one pump fluidly coupled to the fluid channels, the at least one pump and the independent fluid channels differing from each other in number, wherein (i) a pump is configured to apply positive pressure to the first fluid channel so as to drive fluid from the fluid reservoir therethrough, and (ii) a pump is configured to apply negative pressure to the second fluid channel; and a connector for removably connecting the fluid channels to the at least one reservoir.

    Abstract translation: 一种用于重新填充具有至少一个储存器的可植入泵的工具。 该工具包括多个独立的流体通道; 流体储存器，其与所述流体通道中的第一流体流体连通; 流体地联接到流体通道的至少一个泵，所述至少一个泵和独立流体通道在数量上彼此不同，其中（i）泵构造成对第一流体通道施加正压以驱动流体 并且（ii）泵构造成对第二流体通道施加负压; 以及用于将所述流体通道可移除地连接到所述至少一个储存器的连接器。

    Implantable intraocular pressure drain
    9.
    发明授权
    Implantable intraocular pressure drain 有权
    植入式眼内压排水

    公开(公告)号：US08246569B1

    公开(公告)日：2012-08-21

    申请号：US11205757

    申请日：2005-08-16

    Applicant: Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

    Inventor： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

    IPC: A61M5/00

    CPC classification number: A61F9/00781 ,  A61B3/16 ,  A61B5/4836 ,  A61B5/6821 ,  A61B2562/0247 ,  A61B2562/028 ,  A61B2562/12 ,  F16K99/0009 ,  F16K99/0057 ,  F16K2099/0086

    Abstract: An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical value, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.

    Abstract translation: 植入的聚对二甲苯管分流器可减轻眼内压力。 该装置在眼睛的前房中植入开放端，允许多余的液体通过管排出眼睛。 在一个实施例中，仅植入眼睛前房的管的第一端是开放的。 然后监测眼内压（IOP），例如利用植入的传感器。 当眼压超过临界值时，从业人员介入，用激光穿刺位于眼睛外部的管的薄化区域，从而引起流体排出并释放压力。 根据替代实施例，管的两端是开放的，并且管包括被配置为允许IOP超过临界值的排水的单向阀。 管可以包括突出的倒钩以将管锚定在眼睛中而不需要缝线。

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