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1.发明申请BIOCOMPATIBLE SUBSTRATE FOR FACILITATING INTERCONNECTIONS BETWEEN STEM CELLS AND TARGET TISSUES AND METHODS FOR IMPLANTING SAME 审中-公开用于促进干细胞和靶组织之间的互连的生物成分基底及其相关的方法公开(公告)号：US20150147377A1
公开(公告)日：2015-05-28
申请号：US14314994
申请日：2014-06-25
申请人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
发明人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
CPC分类号： A61L27/18 , A61K9/0051 , A61K35/30 , A61K35/545 , A61K47/34 , A61L27/3813 , A61L27/3834 , A61L27/56 , A61L2430/00 , A61L2430/16 , Y10T428/24479
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译： 本文公开了用于细胞递送至需要治疗诱发细胞死亡，损伤或丧失功能的各种疾病的靶组织的底物。 衬底被配置成提供包括干细胞的种子细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。
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公开(公告)号：US10478206B2
公开(公告)日：2019-11-19
申请号：US14114160
申请日：2012-04-27
申请人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , Robert Grubbs , Rodrigo Brant , Trent Wells , Lincoln Vallance Johnson , Sherry T. Hikita , David Hinton
发明人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , Robert Grubbs , Rodrigo Brant , Trent Wells , Lincoln Vallance Johnson , Sherry T. Hikita , David Hinton
IPC分类号： A61B17/29 , A61F9/007 , A61L27/16 , A61L27/34 , A61L27/38 , A61L27/50 , A61K35/50 , C12N5/079 , A61F2/14 , A61F2/46 , A61F9/00 , A61M1/12 , A61M5/14 , A61B17/30
摘要： Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
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公开(公告)号：US20150032207A1
公开(公告)日：2015-01-29
申请号：US14114160
申请日：2012-04-27
申请人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , Robert Grubbs , Rodrigo Brant , Trent Wells , Lincoln Vallance Johnson , Sherry T. Hikita , David Hinton
发明人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , Robert Grubbs , Rodrigo Brant , Trent Wells , Lincoln Vallance Johnson , Sherry T. Hikita , David Hinton
CPC分类号： A61B17/2909 , A61B2017/2937 , A61B2017/2945 , A61B2017/305 , A61F2/14 , A61F2/4601 , A61F9/0017 , A61F9/00736 , A61K35/50 , A61L27/16 , A61L27/34 , A61L27/3813 , A61L27/50 , A61L2430/16 , A61M1/12 , A61M5/14 , A61M2202/09 , C12N5/0621 , C12N2506/02 , C12N2533/30 , C12N2533/40 , C12N2533/50 , C08L65/04 , C08L89/00
摘要： Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译： 本文公开了用于将底物（包括细胞接种的底物）递送至需要治疗诱导细胞死亡，损伤或功能丧失的各种疾病的靶组织的仪器和方法。 衬底被配置为提供包括干细胞的细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。
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4.发明授权Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same 有权用于促进干细胞和靶组织之间的互连的生物相容性底物及其植入方法公开(公告)号：US08808687B2
公开(公告)日：2014-08-19
申请号：US13181279
申请日：2011-07-12
申请人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg , Lincoln V. Johnson , Sherry T. Hikita
发明人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg , Lincoln V. Johnson , Sherry T. Hikita
CPC分类号： A61L27/18 , A61K9/0051 , A61K35/30 , A61K35/545 , A61K47/34 , A61L27/3813 , A61L27/3834 , A61L27/56 , A61L2430/00 , A61L2430/16 , Y10T428/24479
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译： 本文公开了用于细胞递送至需要治疗诱发细胞死亡，损伤或丧失功能的各种疾病的靶组织的底物。 衬底被配置成提供包括干细胞的种子细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。
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5.发明申请BIOCOMPATIBLE SUBSTRATE FOR FACILITATING INTERCONNECTIONS BETWEEN STEM CELLS AND TARGET TISSUES AND METHODS FOR IMPLANTING SAME 有权用于促进干细胞和靶组织之间的互连的生物成分基底及其相关的方法公开(公告)号：US20120009159A1
公开(公告)日：2012-01-12
申请号：US13181279
申请日：2011-07-12
申请人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg
发明人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg
CPC分类号： A61L27/18 , A61K9/0051 , A61K35/30 , A61K35/545 , A61K47/34 , A61L27/3813 , A61L27/3834 , A61L27/56 , A61L2430/00 , A61L2430/16 , Y10T428/24479
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译： 本文公开了用于细胞递送至需要治疗诱发细胞死亡，损伤或丧失功能的各种疾病的靶组织的底物。 衬底被配置成提供包括干细胞的种子细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。
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公开(公告)号：US20050246018A1
公开(公告)日：2005-11-03
申请号：US11118253
申请日：2005-04-29
申请人： Robert Grubbs , Axel Brait , Shiao Chang , Okihiro Nishi , Daniel Schwartz
发明人： Robert Grubbs , Axel Brait , Shiao Chang , Okihiro Nishi , Daniel Schwartz
CPC分类号： A61F2/1613 , A61F2/1629 , A61F2/1635 , A61F9/0017 , A61F2002/30583 , A61F2210/0085 , A61F2250/0012 , A61L31/06 , A61L2430/16 , C08L83/04
摘要： The invention relates to a novel composition for improving the accommodation capability of an intraocular lens (IOL). In one embodiment, the composition can be injected into the capsular bag where it surrounds an implanted IOL anchoring the IOL to the capsular bag. Alternatively, for anterior chamber IOLs, the composition can be injected into the bag behind the lens. The material has a refractive index similar to that of aqueous thereby reducing any potential interference with the implanted IOL. Accommodation is provided by the mixture of the crosslinked composition caused by the flexing of the muscles. The novel composition is particularly useful in enhancing accommodation for adjustable intraocular lenses.
摘要翻译： 本发明涉及一种用于改善人工晶状体（IOL）适应能力的新型组合物。 在一个实施方案中，组合物可以注射到囊袋中，其中其围绕将IOL锚定到囊袋的植入的IOL。 或者，对于前房IOL，可以将组合物注入镜片后面的袋中。 该材料具有类似于水的折射率，从而减少与植入的IOL的任何潜在干扰。 通过由肌肉的弯曲引起的交联组合物的混合物提供住宿。 该新颖的组合物特别可用于增加可调节眼内透镜的适应性。
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公开(公告)号：US20050195361A1
公开(公告)日：2005-09-08
申请号：US11093899
申请日：2005-03-30
CPC分类号： A61F2/1613 , B29D11/00038 , B29D11/00461 , G02B1/041 , G02B1/043 , G02B3/0087 , G02C7/02 , G02C7/04 , G02C2202/14
摘要： The invention relates to a method of customizing lenses using an external stimulus such as light. Fine-tuning of the lens to match the precise optical requirements using the same lens is also possible. The lenses are self-contained and do not require the addition or removal of significant portions of the lens to achieve customization.
摘要翻译： 本发明涉及使用诸如光的外部刺激来定制镜片的方法。 使用相同的镜头对镜头进行微调以匹配精确的光学要求也是可能的。 透镜是独立的，并且不需要增加或移除透镜的重要部分以实现定制。
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公开(公告)号：US20050018310A1
公开(公告)日：2005-01-27
申请号：US10871686
申请日：2004-06-17
申请人： Julia Kornfield , Robert Grubbs , Shiao Chang
发明人： Julia Kornfield , Robert Grubbs , Shiao Chang
CPC分类号： A61F2/1613 , A61F2/16 , A61F2/1627 , A61F2/1635 , A61F2002/1699 , B29D11/00442 , B29D11/023 , G02B1/043 , G02C2202/14 , C08L83/04
摘要： Methods and materials are disclosed for the production of optical elements, in particular intraocular lenses (IOL) that incorporate any amount (0 to 99%) of refraction and/or shape modulating compound into a substantially crosslinked first polymeric matrix. The materials produced according to the inventive methods exhibit certain rheological parameters useful in defining medical lenses. These medical lenses have the ability to change their refractive power via changing the refractive index and/or by altering the shape by stimulus induced polymerization.
摘要翻译： 公开了用于生产光学元件的方法和材料，特别是将任何量（0至99％）的折射和/或形状调节化合物掺入基本交联的第一聚合物基质中的眼内透镜（IOL）。 根据本发明方法生产的材料表现出用于定义医用透镜的某些流变参数。 这些医用透镜具有通过改变折射率和/或通过刺激诱导聚合来改变形状而改变它们的屈光力的能力。
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公开(公告)号：US08394330B1
公开(公告)日：2013-03-12
申请号：US09409644
申请日：1999-10-01
CPC分类号： G01N27/126 , G01N33/497
摘要： The present invention provides a class of sensors prepared from regions of conducting organic materials and conducting materials that show an increase sensitivity detection limit for amines. The present class of sensors have applications in the detection of spoiled food products and in testing for diseases, such as cholera and lung cancer, which have amines as biomarkers.
摘要翻译： 本发明提供了一种由导电有机材料和导电材料的区域制备的传感器，这些传导材料显示出胺的灵敏度检测极限。 目前的传感器类型可以用于检测食品中的宠坏食物，以及检测具有胺作为生物标志物的霍乱和肺癌等疾病。
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公开(公告)号：US20070035698A1
公开(公告)日：2007-02-15
申请号：US11454472
申请日：2006-06-16
IPC分类号： A61B3/00
CPC分类号： G02B3/00 , A61F2/1627 , A61F2/1635 , A61L27/18 , A61L2430/16 , G02B1/043 , G02C7/04 , G02C2202/14 , C08L83/04
摘要： The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. When at least a portion of the lens is exposed to an appropriate stimulus, the refraction modulating composition forms a second polymer matrix. The amount and location of the second polymer matrix may modify a lens characteristic such as lens power by changing its refractive index and/or by altering its shape. The inventive lenses have a number of applications in the electronics and medical fields as data storage means and as medical lenses, particularly intraocular lenses, respectively.
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