摘要:
A compound represented by formula (I): ##STR1## wherein all symbols are defined in the specification, or an acid addition salt thereof or a hydrate thereof; a process for preparing the same; and a nitrogen monoxide synthase inhibitor comprising the same as an active ingredient.
摘要:
A compound represented by formula (I): wherein all symbols are defined in the specification, or an acid addition salt thereof or a hydrate thereof; a process for preparing the same; and a nitrogen monoxide synthase inhibitor comprising the same as an active ingredient.
摘要:
Provided is an oscillation device capable of obtaining a stable oscillation frequency by compensating for a change in oscillation frequency caused with an elapse of operating time of a quartz-crystal oscillator. A difference value ΔF between a frequency difference between first and second quartz-crystal oscillators after a predetermined period of time has elapsed from a reference time and a frequency difference between the first and second quartz-crystal oscillators at the reference time is determined.
摘要:
There is provided a signal processing device and a wireless apparatus capable of not erroneously determining polarity, appropriately performing a spread modulation process, a carrier modulation process, and reception data demodulation process, improving reception accuracy, and miniaturizing a circuit, even when IF carrier frequency shift occurs. The signal processing device and the wireless apparatus includes a spread modulation unit which includes a first differential encoding process section for performing a differential encoding process on a reception data, a differential encoding process section for performing a second differential encoding process on the output, and a spread modulation process section for performing a spread modulation process on the output using a spread code; a carrier modulation unit which quadrature-modulates a transmission data spread modulation signal and a continuous wave; and a reception data decoding unit which performs a correlation process twice and a delay detection process twice.
摘要:
A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g., scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis, etc. Since it specifically binds to DP receptor and binds weakly to other prostaglandins receptors, they can be pharmaceuticals having little side effect.
摘要:
An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the compound represented by formula (I) binds to EP2 subtype among PGE receptor strongly, it is useful for preventive and/or treatment for immune diseases, allergic diseases, neuronal cell death, dysmenorrhea, premature birth, abortion, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, liver cirrhosis, shock, nephritis, renal failure, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagocytosis syndrome, macrophage activation syndrome, still disease, Kawasaki Disease, burn, systemic granuloma, ulcerative colitis, Crohn disease, hypercytokinemia at dialysis, multiple organ failure, or bone diseases etc.
摘要:
A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).
摘要:
A wireless communication device is provided to carry out correlation peak detection processing properly and efficiently in intermittent receiving unit. If a correlation peak is not detected in a first period in which a correlation peak detecting unit detects the correlation peak at a default frequency and a first frequency in a detecting period of a coarse frequency deviation detecting unit in the first period, a control unit makes the correlation peak detecting unit carry out the peak detection at the first frequency in a second period. If the correlation peak is detected in the correlation peak detecting unit and a second frequency is detected in a detecting period of a fine frequency deviation detecting unit in the first period, the control unit makes the correlation peak detecting unit carry out the peak detection at the first and second frequencies in a third period.
摘要:
A signal processing unit and a wireless communication device are provided for making it possible to detect a frequency by means of a small scale operation circuit in a short time. The signal processing unit and the wireless communication device are comprised of a carrier data generating unit; a carrier demodulation unit; a matched filter unit that divides carrier demodulated data into a plurality of portions, carries out despread processing and accumulating operation processing as partial correlation processing, further carries out full addition processing for the partial correlation processing result, and outputs correlation detected data; a correlation peak detecting unit that detects a correlation peak from the correlation detected data and outputs correlation peak position information; a coarse frequency deviation detecting unit that outputs a frequency deviation amount with respect to the carrier demodulated data to the carrier data generating unit; and a fine frequency deviation detecting unit that outputs a fine frequency deviation amount from the correlation detected data and the correlation peak position information to the carrier data generating unit.
摘要:
An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
摘要翻译:式(I)的N-苯基芳基磺酰胺化合物(R 1)是COOH等; R 2是氢,甲基等; R 3 O >和R 4是甲基和甲基等的组合; R 5是异丙基等; Ar是噻唑基,吡啶基,5-甲基-2-呋喃基 任选被甲基取代; n为0或1),化合物的合成中间体及其制备方法。 式(I)化合物与前列腺素E 2受体结合,特别是EP 1亚型受体,并拮抗它。 蛋白质结合的影响较小,因此具有令人满意的体内活性。 因此,认为可用作止痛剂,解热剂,治疗尿频(尿频)和/或下尿路疾病综合征或抗肿瘤药物的药剂。