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公开(公告)号：US08445286B2
公开(公告)日：2013-05-21
申请号：US12514052
申请日：2007-11-07
CPC分类号： G01N15/1404 , G01N2015/1413 , Y10T29/49826 , Y10T137/0352 , Y10T137/0379 , Y10T137/0419 , Y10T436/115831 , Y10T436/117497
摘要： The flow cytometer system of the preferred embodiment includes a flow cell body that functions to contain, protect, and align the components of the flow cytometer system; a flow channel, coupled to the flow cell body, that functions to conduct and focus sample fluid through an interrogation zone; and a sample injection probe, removably coupled to the flow cell body, that functions to provide a uniform flow of sample fluid to the flow channel. The flow cytometer system is preferably designed for the flow cytometer field. The flow cytometer system, however, may be alternatively used in any suitable environment and for any suitable reason.
摘要翻译： 优选实施例的流式细胞仪系统包括流动池体，其用于容纳，保护和对准流式细胞仪系统的组件; 耦合到流动池主体的流动通道，其用于将样品流体引导和聚焦通过询问区; 以及可移除地耦合到流动池主体的样品注入探针，其用于提供样品流体到流动通道的均匀流动。 流式细胞仪系统优选设计用于流式细胞仪领域。 然而，流式细胞仪系统可以替代地在任何合适的环境中用于任何合适的原因。
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公开(公告)号：US20100118298A1
公开(公告)日：2010-05-13
申请号：US12514052
申请日：2007-11-07
CPC分类号： G01N15/1404 , G01N2015/1413 , Y10T29/49826 , Y10T137/0352 , Y10T137/0379 , Y10T137/0419 , Y10T436/115831 , Y10T436/117497
摘要： The flow cytometer system of the preferred embodiment includes a flow cell body that functions to contain, protect, and align the components of the flow cytometer system; a flow channel, coupled to the flow cell body, that functions to conduct and focus sample fluid through an interrogation zone; and a sample injection probe, removably coupled to the flow cell body, that functions to provide a uniform flow of sample fluid to the flow channel. The flow cytometer system is preferably designed for the flow cytometer field. The flow cytometer system, however, may be alternatively used in any suitable environment and for any suitable reason.
摘要翻译： 优选实施例的流式细胞仪系统包括流动池主体，其用于容纳，保护和对准流式细胞仪系统的部件; 耦合到流动池主体的流动通道，其用于将样品流体引导和聚焦通过询问区; 以及可移除地耦合到流动池主体的样品注入探针，其用于提供样品流体到流动通道的均匀流动。 流式细胞仪系统优选设计用于流式细胞仪领域。 然而，流式细胞仪系统可以替代地在任何合适的环境中用于任何合适的原因。
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公开(公告)号：US20100319786A1
公开(公告)日：2010-12-23
申请号：US12857405
申请日：2010-08-16
申请人： Nathaniel C. Bair , Collin A. Rich
发明人： Nathaniel C. Bair , Collin A. Rich
CPC分类号： F04B23/04 , F04B43/0081 , F04B43/12 , F04B2201/1201 , F04B2205/09 , G01N15/1404 , G01N2015/1413 , G05D7/0682 , Y10T137/0352 , Y10T137/0379 , Y10T137/0402 , Y10T137/85986 , Y10T436/115831 , Y10T436/117497
摘要： The fluidic system with an unclogging feature of the preferred embodiment includes a flow channel, a sheath pump to pump sheath fluid from a sheath container into an interrogation zone, and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from a sample container into the interrogation zone. The fluidic system also includes a controller to adjust the flow rate of the sample fluid from the sample container into the interrogation zone. The pump and controller cooperate to propagate a pulsation through the flow channel from the pump if the flow channel is clogged. The fluidic system is preferably incorporated into a flow cytometer with a flow cell that includes the interrogation zone.
摘要翻译： 具有优选实施例的不记录特征的流体系统包括流动通道，用于将护套流体从鞘容器泵送到询问区域的护套泵以及将废液从询问区泵送到废物容器中的废水泵。 护套泵和/或废水泵将样品流体从样品容器中抽入询问区。 流体系统还包括控制器，用于调节样品流体从样品容器进入询问区域的流速。 如果流道被堵塞，泵和控制器协同传播来自泵的流动通道的脉动。 流体系统优选地结合到具有包括询问区的流动池的流式细胞仪中。
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公开(公告)号：US20110058168A1
公开(公告)日：2011-03-10
申请号：US12887392
申请日：2010-09-21
申请人： Collin A. Rich , Nathaniel C. Bair
发明人： Collin A. Rich , Nathaniel C. Bair
IPC分类号： G01N21/17
CPC分类号： G01N21/53 , G01N15/1434 , G01N21/532 , G01N21/645 , G01N2021/4707 , G01N2021/4711 , G01N2021/4726 , G01N2021/6497 , Y10T436/12
摘要： An optical system for a flow cytometer having a flow channel with an interrogation zone and an illumination source that impinges the flow channel in the interrogation zone includes a lens system and a detection system. The lens system preferably includes at least two lens surfaces located on opposite sides of the flow channel and configured to collect and collimate light from the interrogation zone. The detection system, configured to detect light from the lens system, preferably includes first and second detectors, a first filter that passes a first wavelength of light and reflects a second wavelength of light, and a second filter that reflects the first wavelength of light and passes the second wavelength of light, wherein the first and second filters are aligned such that light reflected from the first filter passes into the second detector and light reflected from the second filter passes into the first detector.
摘要翻译： 具有流动通道的流式细胞仪的光学系统具有询问区的流动通道和将询问区中的流动通道照射的照明源包括透镜系统和检测系统。 透镜系统优选地包括位于流动通道的相对侧上的至少两个透镜表面，并且被配置为收集和准直来自询问区的光。 被配置为检测来自透镜系统的光的检测系统优选地包括第一和第二检测器，通过第一波长的光并反射第二波长的光的第一滤光器和反射第一波长的光的第二滤光器，以及 通过第二波长的光，其中第一和第二滤光器对齐，使得从第一滤光片反射的光线进入第二检测器，并且从第二滤光器反射的光线进入第一检测器。
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公开(公告)号：US20090260701A1
公开(公告)日：2009-10-22
申请号：US12425830
申请日：2009-04-17
申请人： Collin A. Rich , Nathaniel C. Bair
发明人： Collin A. Rich , Nathaniel C. Bair
IPC分类号： F16L55/04
CPC分类号： F16L55/04 , F04B43/12 , F15B1/021 , F15B1/10 , F15B21/008 , F15B2201/205 , F15B2201/215 , F15B2201/3151 , G01N15/1404 , G01N15/1459 , Y10T137/3118
摘要： A pulsation attenuator for a fluidic system with a fluidic pump. The pulsation attenuator includes a fluidic channel, a first fluidic device adapted to attenuate pulsations, and a second fluidic device adapted to attenuate pulsations. Preferably, the first fluidic device includes a first fluidic resistor and a first fluidic capacitor, and the second fluidic device includes a second fluidic resistor and a second fluidic capacitor. Preferably, the first fluidic resistor and second fluidic resistor are resistive channels. Preferably, the first fluidic capacitor and second fluidic capacitor include a membrane that expands and accumulates fluid and then contracts and reintroduces the accumulated fluid into the fluidic channel.
摘要翻译： 一种具有流体泵的流体系统的脉动衰减器。 脉动衰减器包括流体通道，适于衰减脉动的第一流体装置，以及适于衰减脉动的第二流体装置。 优选地，第一流体装置包括第一流体电阻器和第一流体电容器，并且第二流体装置包括第二流体电阻器和第二流体电容器。 优选地，第一流体电阻器和第二流体电阻器是电阻通道。 优选地，第一流体电容器和第二流体电容器包括膨胀和积聚流体然后收缩并将积聚的流体再引入流体通道的膜。
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公开(公告)号：US08283177B2
公开(公告)日：2012-10-09
申请号：US12476860
申请日：2009-06-02
申请人： Jack T. Ball , Aaron Kehrer , Nathaniel C. Bair , Collin A. Rich
发明人： Jack T. Ball , Aaron Kehrer , Nathaniel C. Bair , Collin A. Rich
CPC分类号： G01N15/1404 , B01L3/02 , B01L3/5027 , B01L99/00 , G01N2015/1413 , G05D7/0682 , Y10T436/25375
摘要： A method for cleaning a fluidic system of a flow cytometer having a sheath pump to pump sheath fluid towards an interrogation zone and a waste pump to pump the sheath fluid and a sample fluid as waste fluid from the interrogation zone, wherein the sheath pump and/or the waste pump draw sample fluid into the flow cytometer through a drawtube towards the interrogation zone. The method includes controlling the sheath pump and the waste pump to cooperatively flush a fluid out through the drawtube, thereby cleaning the fluidic system of the flow cytometer.
摘要翻译： 一种用于清洗流式细胞仪的流体系统的方法，所述流式细胞仪具有护套泵以将鞘液朝向询问区泵送，而废泵泵送鞘液和作为来自询问区的废液的样品流体，其中护套泵和/ 或废泵将样品流体通过拉管朝向询问区抽入流式细胞仪。 该方法包括控制护套泵和废水泵通过抽吸管共同冲洗流体，从而清洗流式细胞仪的流体系统。
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公开(公告)号：US07857005B2
公开(公告)日：2010-12-28
申请号：US12425830
申请日：2009-04-17
申请人： Collin A. Rich , Nathaniel C. Bair
发明人： Collin A. Rich , Nathaniel C. Bair
IPC分类号： F16L55/04
CPC分类号： F16L55/04 , F04B43/12 , F15B1/021 , F15B1/10 , F15B21/008 , F15B2201/205 , F15B2201/215 , F15B2201/3151 , G01N15/1404 , G01N15/1459 , Y10T137/3118
摘要： A pulsation attenuator for a fluidic system with a fluidic pump. The pulsation attenuator includes a fluidic channel, a first fluidic device adapted to attenuate pulsations, and a second fluidic device adapted to attenuate pulsations. Preferably, the first fluidic device includes a first fluidic resistor and a first fluidic capacitor, and the second fluidic device includes a second fluidic resistor and a second fluidic capacitor. Preferably, the first fluidic resistor and second fluidic resistor are resistive channels. Preferably, the first fluidic capacitor and second fluidic capacitor include a membrane that expands and accumulates fluid and then contracts and reintroduces the accumulated fluid into the fluidic channel.
摘要翻译： 一种具有流体泵的流体系统的脉动衰减器。 脉动衰减器包括流体通道，适于衰减脉动的第一流体装置，以及适于衰减脉动的第二流体装置。 优选地，第一流体装置包括第一流体电阻器和第一流体电容器，并且第二流体装置包括第二流体电阻器和第二流体电容器。 优选地，第一流体电阻器和第二流体电阻器是电阻通道。 优选地，第一流体电容器和第二流体电容器包括膨胀和积聚流体然后收缩并将积聚的流体再引入流体通道的膜。
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公开(公告)号：US20090201501A1
公开(公告)日：2009-08-13
申请号：US12197192
申请日：2008-08-22
IPC分类号： G01N21/53
CPC分类号： G01N21/53 , G01N15/1434 , G01N2021/6497 , Y10T436/115831
摘要： The preferred embodiments of the invention is an optical system for a flow cytometer including a flow channel with an interrogation zone, and an illumination source that impinges the flow channel in the interrogation zone from a particular direction. The optical system preferably includes a lens system and a detection system. The lens system preferably includes multiple lens surfaces arranged around the flow channel and adapted to collect and collimate light from the interrogation zone. The detection system preferably includes multiple detectors adapted to detect light from the lens system. Each detector preferably includes a local filter that independently filters for specific wavelengths. Thus, the user may easily swap the filters in any order to achieve the same detection parameters.
摘要翻译： 本发明的优选实施例是用于流式细胞仪的光学系统，其包括具有询问区的流动通道，以及照射源，其将特定方向上的询问区中的流动通道入射。 光学系统优选地包括透镜系统和检测系统。 透镜系统优选地包括围绕流动通道设置的多个透镜表面，并且适于收集和准直来自询问区域的光。 检测系统优选地包括适于检测来自透镜系统的光的多个检测器。 每个检测器优选地包括独立地滤波特定波长的局部滤波器。 因此，用户可以以任何顺序容易地交换滤波器以实现相同的检测参数。
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公开(公告)号：US08149402B2
公开(公告)日：2012-04-03
申请号：US12197192
申请日：2008-08-22
IPC分类号： G01N21/00
CPC分类号： G01N21/53 , G01N15/1434 , G01N2021/6497 , Y10T436/115831
摘要： The preferred embodiments of the invention is an optical system for a flow cytometer including a flow channel with an interrogation zone, and an illumination source that impinges the flow channel in the interrogation zone from a particular direction. The optical system preferably includes a lens system and a detection system. The lens system preferably includes multiple lens surfaces arranged around the flow channel and adapted to collect and collimate light from the interrogation zone. The detection system preferably includes multiple detectors adapted to detect light from the lens system. Each detector preferably includes a local filter that independently filters for specific wavelengths. Thus, the user may easily swap the filters in any order to achieve the same detection parameters.
摘要翻译： 本发明的优选实施例是用于流式细胞仪的光学系统，其包括具有询问区的流动通道，以及照射源，其将特定方向上的询问区中的流动通道入射。 光学系统优选地包括透镜系统和检测系统。 透镜系统优选地包括围绕流动通道布置的多个透镜表面，并且适于收集和准直来自询问区域的光。 检测系统优选地包括适于检测来自透镜系统的光的多个检测器。 每个检测器优选地包括独立地滤波特定波长的局部滤波器。 因此，用户可以以任何顺序容易地交换滤波器以实现相同的检测参数。
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公开(公告)号：US08031340B2
公开(公告)日：2011-10-04
申请号：US12887392
申请日：2010-09-21
申请人： Collin A. Rich , Nathaniel C. Bair
发明人： Collin A. Rich , Nathaniel C. Bair
IPC分类号： G01N21/00
CPC分类号： G01N21/53 , G01N15/1434 , G01N21/532 , G01N21/645 , G01N2021/4707 , G01N2021/4711 , G01N2021/4726 , G01N2021/6497 , Y10T436/12
摘要： An optical system for a flow cytometer having a flow channel with an interrogation zone and an illumination source that impinges the flow channel in the interrogation zone includes a lens system and a detection system. The lens system preferably includes at least two lens surfaces located on opposite sides of the flow channel and configured to collect and collimate light from the interrogation zone. The detection system, configured to detect light from the lens system, preferably includes first and second detectors, a first filter that passes a first wavelength of light and reflects a second wavelength of light, and a second filter that reflects the first wavelength of light and passes the second wavelength of light, wherein the first and second filters are aligned such that light reflected from the first filter passes into the second detector and light reflected from the second filter passes into the first detector.
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