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    Methods and apparatus for heart failure treatment
    1.
    发明授权
    Methods and apparatus for heart failure treatment 有权
    心力衰竭治疗方法及装置

    公开(公告)号：US09283341B2

    公开(公告)日：2016-03-15

    申请号：US13718084

    申请日：2012-12-18

    Applicant: ResMed Limited

    Inventor： Anthony John Ujhazy ,  Jonathan Caldwell Wright ,  Glenn Richards ,  David John Bassin ,  Michael Berthon-Jones

    IPC: A61M16/00 ,  A61M16/06

    CPC classification number: A61B5/4836 ,  A61B5/0826 ,  A61B5/087 ,  A61B5/7282 ,  A61B5/746 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/0066 ,  A61M16/0069 ,  A61M16/024 ,  A61M16/06 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2205/3344 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/10 ,  A61M2230/18 ,  A61M2230/40 ,  A61M2230/435 ,  A61M2230/63

    Abstract: Methods and apparatus for assessing the condition of and treating patients for heart failure by the delivery of continuous positive airway pressure are disclosed. Treatment of obstruction due to reflex vocal cord closure often experienced by heart failure patients is distinguished from treatment of upper airway obstruction typically associated with Obstructive Sleep Disorder. Treatment may also be implemented by delivering synchronized cardiac pressure oscillations superimposed on a respiratory pressure level to provide assistance for the heart. Heart treatment pressure dose indicator may be calculated for prescribing and monitoring the delivery of treatment. The apparatus may also generate data to track heart failure condition that may be indicative of the degree of severity of heart failure based upon breathing patterns to assist in the diagnosis and management of heart failure patients.

    Abstract translation: 公开了通过递送持续气道正压通气来评估患者心力衰竭状况和治疗方法和装置。 治疗由于心力衰竭患者经常发生的反射性声带闭塞引起的阻塞与治疗通常与阻塞性睡眠障碍相关的上呼吸道阻塞是不同的。 治疗也可以通过递送叠加在呼吸压力水平上的同步心脏压力振荡来提供对心脏的辅助来实现。 可以计算心脏治疗压力剂量指标，用于处方和监测治疗的递送。 该装置还可以生成跟踪心力衰竭状况的数据，该状况可以基于呼吸模式来指示心力衰竭的严重程度，以帮助心力衰竭患者的诊断和管理。

    VENTILATORY ASSISTANCE FOR TREATMENT OF CARDIAC FAILURE AND CHEYNE-STOKES BREATHING
    2.
    发明申请
    VENTILATORY ASSISTANCE FOR TREATMENT OF CARDIAC FAILURE AND CHEYNE-STOKES BREATHING 有权
    治疗心脏病失败和呼吸道呼吸的通气辅助

    公开(公告)号：US20140069430A1

    公开(公告)日：2014-03-13

    申请号：US13962493

    申请日：2013-08-08

    Applicant: RESMED LIMITED

    Inventor： Michael Berthon-Jones

    IPC: A61M16/00

    CPC classification number: A61M16/0003 ,  A61M16/00 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/0069 ,  A61M16/024 ,  A61M16/0858 ,  A61M2016/0039 ,  A61M2205/3303 ,  A61M2230/42

    Abstract: Method and apparatus for the treatment of cardiac failure, Cheyne Stokes breathing or central sleep apnea are disclosed. A subject is provided with ventilatory support. Respiratory airflow is determined. From the respiratory airflow are derived a measure of instantaneous ventilation and a measure of longterm average ventilation. A target ventilation is taken as 95% of the longterm average ventilation. The instantaneous ventilation is fed as the input signal to a clipped integral controller, with the target ventilation as the reference signal. The output of the controller determines the degree of ventilatory support. A third measure of ventilation, for example instantaneous ventilation low pass filtered with a time constant of 5 seconds, is calculated. Ventilatory support is in phase with the subject's respiratory airflow to the fuzzy extent that this ventilation is above target, and at a preset rate conversely.

    Abstract translation: 公开了用于治疗心力衰竭，Cheyne Stokes呼吸或中枢性睡眠呼吸暂停的方法和装置。 受试者提供通气支持。 确定呼吸气流。 从呼吸气流得出瞬时通气的度量和长期平均通气量的测量。 目标通气量为长期平均通气量的95％。 瞬时通风作为输入信号输入到夹紧积分控制器，目标通风作为参考信号。 控制器的输出决定通气支持的程度。 计算第三种通气量，例如用5秒的时间常数过滤的瞬时通风低通量。 通气支持与受试者的呼吸气流同步，模糊程度是这种通气高于目标，并且以相反的预设速率。

    METHODS AND APPARATUS FOR HEART FAILURE TREATMENT
    3.
    发明申请
    METHODS AND APPARATUS FOR HEART FAILURE TREATMENT 有权
    心脏治疗的方法和装置

    公开(公告)号：US20130118494A1

    公开(公告)日：2013-05-16

    申请号：US13718084

    申请日：2012-12-18

    Applicant: ResMed Limited

    Inventor： Anthony John Ujhazy ,  Jonathan Caldwell Wright ,  Glenn Richards ,  David John Bassin ,  Michael Berthon-Jones

    IPC: A61M16/00 ,  A61M16/06

    CPC classification number: A61B5/4836 ,  A61B5/0826 ,  A61B5/087 ,  A61B5/7282 ,  A61B5/746 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/0066 ,  A61M16/0069 ,  A61M16/024 ,  A61M16/06 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2205/3344 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/10 ,  A61M2230/18 ,  A61M2230/40 ,  A61M2230/435 ,  A61M2230/63

    Abstract: Methods and apparatus for assessing the condition of and treating patients for heart failure by the delivery of continuous positive airway pressure are disclosed. Treatment of obstruction due to reflex vocal cord closure often experienced by heart failure patients is distinguished from treatment of upper airway obstruction typically associated with Obstructive Sleep Disorder. Treatment may also be implemented by delivering synchronized cardiac pressure oscillations superimposed on a respiratory pressure level to provide assistance for the heart. Heart treatment pressure dose indicator may be calculated for prescribing and monitoring the delivery of treatment. The apparatus may also generate data to track heart failure condition that may be indicative of the degree of severity of heart failure based upon breathing patterns to assist in the diagnosis and management of heart failure patients.

    Abstract translation: 公开了通过递送持续气道正压通气来评估患者心力衰竭状况和治疗方法和装置。 治疗由于心力衰竭患者经常发生的反射性声带闭塞引起的阻塞与治疗通常与阻塞性睡眠障碍相关的上呼吸道阻塞是不同的。 治疗也可以通过递送叠加在呼吸压力水平上的同步心脏压力振荡来提供对心脏的辅助来实现。 可以计算心脏治疗压力剂量指标，用于处方和监测治疗的递送。 该装置还可以生成跟踪心力衰竭状况的数据，该状况可以基于呼吸模式来指示心力衰竭的严重程度，以帮助心力衰竭患者的诊断和管理。

    METHOD AND APPARATUS FOR PROVIDING VENTILATORY ASSISTANCE
    5.
    发明申请
    METHOD AND APPARATUS FOR PROVIDING VENTILATORY ASSISTANCE 有权
    提供通气辅助的方法和装置

    公开(公告)号：US20140283835A1

    公开(公告)日：2014-09-25

    申请号：US14224620

    申请日：2014-03-25

    Applicant: RESMED LIMITED

    Inventor： Michael Berthon-Jones

    IPC: A61M16/00 ,  A61M16/06

    CPC classification number: A61M16/0069 ,  A61B5/085 ,  A61B5/087 ,  A61B5/7264 ,  A61M16/0003 ,  A61M16/0051 ,  A61M16/024 ,  A61M16/06 ,  A61M16/1055 ,  A61M16/107 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2205/15

    Abstract: The apparatus provides for the determination of the instantaneous phase in the respiratory cycle, subject's average respiration rate and the provision of ventilatory assistance. A microprocessor (16) receives an airflow signal from a pressure transducer (18) coupled to a port (17) at a mask (11). The microprocessor (16) controls a servo (19), that in turn controls the fan motor (20) and thus the pressure of air delivered by the blower (10). The blower (10) is coupled to a subject's mask (ii) by a conduit (12). The invention seeks to address the following goals: while the subject is awake and making substantial efforts the delivered assistance should be closely matched in phase with the subject's efforts; the machine should automatically adjust the degree of assistance to maintain at least a specified minimum ventilation without relying on the integrity of the subject's chemoreflexes; and it should continue to work correctly in the presence of large leaks.

    Abstract translation: 该装置用于确定呼吸周期中的瞬时相位，受试者的平均呼吸速率和提供通气辅助。 微处理器（16）从在面罩（11）处连接到端口（17）的压力传感器（18）接收气流信号。 微处理器（16）控制伺服机构（19），伺服机构又控制风扇马达（20），从而控制由鼓风机（10）输送的空气的压力。 鼓风机（10）通过导管（12）与受试者的面罩（ii）相连。 本发明旨在解决以下目标：在主体清醒和作出重大努力的同时，所提供的援助应与受试者的努力相一致; 机器应自动调整辅助程度以保持至少指定的最小通风，而不依赖于受试者的化学反应物的完整性; 并且在大泄漏的情况下应该继续正常工作。

    DETERMINATION OF LEAK AND RESPIRATORY AIRFLOW
    10.
    发明申请
    DETERMINATION OF LEAK AND RESPIRATORY AIRFLOW 审中-公开
    确定泄漏和呼吸空气流

    公开(公告)号：US20140331998A1

    公开(公告)日：2014-11-13

    申请号：US14278642

    申请日：2014-05-15

    Applicant: ResMed Limited

    Inventor： Michael Berthon-Jones

    IPC: A61M16/00

    CPC classification number: A61M16/0003 ,  A61M16/0057 ,  A61M16/0069 ,  A61M16/024 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/0033 ,  A61M2016/0036 ,  A61M2205/15

    Abstract: Methods and apparatus for determining leak and respiratory airflow are disclosed. A pressure sensor (34) and a differential pressure sensor (32) have connection with a pneumotach (24) to derive instantaneous mask pressure and airflow respectively. A microcontroller (38) estimates a non-linear conductance of any leak path occurring at a mask (12) as being the low pass filtered instantaneous airflow divided by the low pass filtered square root of the instantaneous pressure. The instantaneous leak flow is then the conductance multiplied by the square root of the instantaneous pressure, and the respiratory airflow is calculated as being the instantaneous airflow minus the instantaneous leak flow. The time constants for the low pass filtering performed by the microcontroller (38) can be dynamically adjusted dependent upon sudden changes in the instantaneous leak flow.

    Abstract translation: 公开了用于确定泄漏和呼吸气流的方法和装置。 压力传感器（34）和差压传感器（32）分别与喘振（24）连接以分别产生瞬时的掩模压力和气流。 微控制器（38）估计出现在掩模（12）处的任何泄漏路径的非线性电导是低通滤波的瞬时气流除以瞬时压力的低通滤波平方根。 瞬时泄漏流量是电导乘以瞬时压力的平方根，呼吸气流被计算为瞬时气流减去瞬时泄漏流量。 由微控制器（38）执行的低通滤波的时间常数可以根据瞬时泄漏流的突然变化而动态调节。

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