利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

390 条记录 (耗时 0.042 秒)

    Protein profile for osteoarthritis
    1.
    发明申请
    Protein profile for osteoarthritis 有权
    骨关节炎的蛋白质谱

    公开(公告)号：US20070207480A1

    公开(公告)日：2007-09-06

    申请号：US11638254

    申请日：2006-12-13

    申请人： Reuben Gobezie ,  David Lee

    发明人： Reuben Gobezie ,  David Lee

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G06F19/00

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/105

    摘要： The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis (OA). In particular, the invention provides the identity of marker proteins whose expressions are correlated with OA, OA subtype, and/or OA progression. Methods and kits are described for using these protein expression profiles in the study and/or diagnosis of OA, in the determination of the degree of advancement of OA, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that modulate expression of these proteins or nucleic acid molecules encoding these proteins, in particular for the development of disease-modifying OA agents.

    摘要翻译： 本发明涉及与骨关节炎（OA）临床相关的蛋白质表达谱的鉴定和应用。 特别地，本发明提供其表达与OA，OA亚型和/或OA进展相关的标记蛋白的身份。 描述了在研究和/或诊断OA中使用这些蛋白质表达谱的方法和试剂盒，以确定OA的进展程度，以及在治疗方案的选择和/或监测中。 本发明还涉及调节这些蛋白质或编码这些蛋白质的核酸分子的表达的药物的筛选，特别是用于发展改变疾病的OA剂。

    VERTICAL SOLUTION INTEGRATOR
    2.
    发明申请
    VERTICAL SOLUTION INTEGRATOR 有权

    公开(公告)号：US20210294585A1

    公开(公告)日：2021-09-23

    申请号：US17210363

    申请日：2021-03-23

    申请人： David Lee

    发明人： David Lee

    IPC分类号： G06F8/41 ,  G06F8/10 ,  G06F8/33 ,  G06N20/00

    摘要： A Vertical Solution Integrator (VSI) enable users to build an application vertical solution system on an AI platform without any coding efforts. The VSI may include a model orchestration system, a model adaptation system, a control module, and analytics engines. The orchestration system interfaces with a user to create a workflow that is based on user requirements and is represented by a Directed Acyclic Graph that includes interacting artificial intelligence, machine learning, computing, or logic models. A GUI enables construction the workflow without need of user coding efforts. The model adaptation subsystem coverts the models into adapted modes that are compatible and interoperable, and the control module assigns analytics engines to execute the adapted models.

    Bone fixation apparatus
    3.
    发明授权
    Bone fixation apparatus 有权

    公开(公告)号：US09421042B2

    公开(公告)日：2016-08-23

    申请号：US13037528

    申请日：2011-03-01

    申请人： David Lee ,  Eric Graham ,  James P. Payne, Jr.

    发明人： David Lee ,  Eric Graham ,  James P. Payne, Jr.

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7037 ,  A61B17/7035 ,  A61B17/7038 ,  A61B17/7041 ,  Y10T29/49826

    摘要： What is provided is a fixation system that offers a strong and stable construct for maximum fusion augmentation and yet is versatile enough for any patient and is easy to use. Disclosed is a connection assembly for connecting a spinal implant, the assembly comprising: a body, the body including a body opening for receiving at least a portion of a first connector; a swivel having first and second ends and being operatively connected to the body, the first end including a swivel opening for receiving at least a portion of a second connector; a locking plate having an arm at least partially extending into the body opening; a locking unit operatively connected to the body and contacting the second end of the swivel; and whereby activation of the locking unit causes the arm to engage the first connector and swivel opening to engage the second connector thereby preventing relative rotation between the first and second connectors.

    Feed routing for object based collaboration
    4.
    发明授权
    Feed routing for object based collaboration 有权
    用于基于对象的协作的馈送路由

    公开(公告)号：US09356978B2

    公开(公告)日：2016-05-31

    申请号：US14144065

    申请日：2013-12-30

    申请人： Ho Kei David Chan ,  David Lee ,  Jay Bryant Wakefield ,  Mark Sullivan

    发明人： Ho Kei David Chan ,  David Lee ,  Jay Bryant Wakefield ,  Mark Sullivan

    IPC分类号： G06F17/30 ,  H04L29/06 ,  G06Q10/10

    CPC分类号： H04L65/403 ,  G06F17/30424 ,  G06Q10/101

    摘要： Systems and methods for routing activity information related to objects in an external application to activity feeds associated with users in a collaboration group are disclosed. When activity information is received, it is routed to collaboration group feeds and user feeds based on a set of routing tables. The routing tables associated objects with events, containers, collaboration groups, and finally users. Based on the routing tables, users who belong to a collaboration groups that are associated with a particular object may see the activity information about that object rendered in an activity feed if the external application grants them permission to access the object. Accordingly, security associated with the object in the external application can be maintained when event information about that object is shared in an activity feed in a collaboration system.

    摘要翻译： 公开了用于将与外部应用中的对象相关的活动信息路由到与协作组中的用户相关联的活动馈送的系统和方法。 当接收到活动信息时，它将基于一组路由表路由到协作组馈送和用户馈送。 路由表将对象与事件，容器，协作组和最终用户相关联。 基于路由表，如果外部应用程序授予他们访问对象的权限，则属于与特定对象关联的协作组的用户可能会看到活动提要中呈现的该对象的活动信息。 因此，当在协作系统中的活动馈送中共享关于该对象的事件信息时，可以维护与外部应用中的对象相关联的安全性。

    MULTITOUCH TOOLS FOR USE WITH A CAPACITIVE TOUCH SENSOR
    7.
    发明申请
    MULTITOUCH TOOLS FOR USE WITH A CAPACITIVE TOUCH SENSOR 审中-公开
    使用电容触摸传感器的多工具

    公开(公告)号：US20150220178A1

    公开(公告)日：2015-08-06

    申请号：US14588884

    申请日：2015-01-02

    申请人： Zachary Joseph Zeliff ,  Kristopher Perpich ,  San-Hsu Chao ,  Peiter Buick ,  Stan Lan ,  David Lee

    发明人： Zachary Joseph Zeliff ,  Kristopher Perpich ,  San-Hsu Chao ,  Peiter Buick ,  Stan Lan ,  David Lee

    IPC分类号： G06F3/044

    CPC分类号： G06F3/044 ,  G06F3/0362 ,  G06F2203/04808

    摘要： Embodiments of a multitouch tool for capacitive touchscreens are disclosed. The multitouch tools have a plurality of conductive posts configured to interact with a capacitive touchscreen of an electronic device such that the touchscreen can determine an orientation of the tool. The tools further have a window through which the touchscreen can display an on-screen control. The user can touch the screen either outside the tool's perimeter or through the window in the tool, or both, to interact with on-screen controls that are generated in response to the electronic device detecting and recognizing the pattern of touches generated by the tool.

    摘要翻译： 公开了用于电容式触摸屏的多点触摸工具的实施例。 多点触摸工具具有多个导电柱，其配置成与电子设备的电容式触摸屏相互作用，使得触摸屏可以确定工具的取向。 这些工具还有一个窗口，触摸屏可以通过该窗口显示屏幕上的控制。 用户可以在工具外围或通过工具中的窗口或两者之间触摸屏幕，以与响应于电子设备检测和识别由工具生成的触摸的图案而生成的屏幕上的控制相互作用。

    Switching device for ratchet wrench
    8.
    发明授权
    Switching device for ratchet wrench 有权
    棘轮扳手开关装置

    公开(公告)号：US09079299B2

    公开(公告)日：2015-07-14

    申请号：US13737912

    申请日：2013-01-09

    申请人： Kuo-Hsien Wu ,  Kuan-Jen Hsieh ,  David Lee

    发明人： Kuo-Hsien Wu ,  Kuan-Jen Hsieh ,  David Lee

    IPC分类号： B25B13/46

    CPC分类号： B25B13/463

    摘要： A switching device of a ratchet wrench includes two engaging members respectively mounted to two rods of an operation member. The operation member has a polygonal shank which extends through the board of the head of the wrench and is connected with a switch. The operation member swings by pivoting the switch so as to control the either of the two engaging members to be engaged with the ratchet driving member. The operation member has a positioning tube, and a bead and a spring are located in the positioning tube. The bead is engaged with one of two recesses of a cover fixed to the head of the wrench when the operation member is pivoted. The cover has a flange on which a locking member is pressed. The locking member is engaged with a fixing portion in the inner periphery of the space.

    摘要翻译： 棘轮扳手的切换装置包括分别安装到操作构件的两个杆的两个接合构件。 操作构件具有多个柄，其延伸穿过扳手的头部的板并与开关连接。 操作构件通过枢转开关摆动，以控制两个接合构件中的任一个与棘轮驱动构件接合。 操作构件具有定位管，并且在定位管中设置有胎圈和弹簧。 当操作构件枢转时，胎圈与固定到扳手的头部的盖的两个凹部中的一个接合。 盖具有法兰，锁定构件被压在该凸缘上。 锁定构件与空间的内周中的固定部分接合。